End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)

NACompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

August 3, 2020

Primary Completion Date

March 24, 2021

Study Completion Date

March 24, 2021

Conditions
Hemodynamic InstabilityGeneral AnesthesiaSurgeryProtective Mechanical Ventilation
Interventions
DIAGNOSTIC_TEST

Diagnostic Test: end-expiratory occlusion (EEO) test

"A set of respiratory and hemodynamic measurements (including cardiac output) will be recorded at each stage:~* T0: baseline.~* T1: At the end of the first EEO (15 sec or 30 sec)~* T2: 1 minute after completion of the first EEO. Return to baseline.~* T3: At the end of the second EEO (15 sec or 30 sec)~* T4: 1 minute after completion of the second EEO. Return to baseline.~* T5: Before the fluid challenge test (4 ml/kg of 0.9% saline over 5 min)~* T6: 1 minute after the end of the fluid challenge~A first set of measurements will be performed after intubation (before the surgical incision) and will be repeated, if necessary, in case of further decrease in stroke volume during surgery or in case of any clinical indication of volume expansion (i.e., arterial persistent hypotension, major hemorrhage, etc.)."

Trial Locations (1)

Unknown

CHU, Clermont-Ferrand

All Listed Sponsors
lead

University Hospital, Clermont-Ferrand

OTHER

NCT04399278 - End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE) | Biotech Hunter | Biotech Hunter