Radiotherapy With Hyperthermia in Recurrent and Radiation-Induced Sarcomas

NACompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

October 23, 2019

Primary Completion Date

June 20, 2023

Study Completion Date

June 20, 2023

Conditions
Radiation Induced NeoplasmsRadiation-Induced CancerRecurrent SarcomaRecurrent Soft Tissue Sarcoma
Interventions
RADIATION

Hypofractionated radiotherapy

Resectable or marginally resectable tumors: preoperative hypofractionated 12x 3 Gy radiotherapy (4 days in a week, three weeks) prescribed on planned target volume (tumor volume + elective margins + setup/error margin) with daily image guidance with cone beam-CT or kV-portal position verification.

OTHER

Hyperthermia

Deep hyperthermia (Celsius TCS or BSD-2000) according to local protocol combined with radiotherapy, twice a week.

RADIATION

Hypofractionated radiotherapy with boost

"Non-resectable/inoperable tumors: definitive hypofractionated 12x 3 Gy radiotherapy prescribed on planned target volume (tumor volume + elective margins + setup/error margin) with simultaneous integrated boost 3.5 Gy per fraction prescribed on boost planned target volume (tumor volume + setup/error margin), 4 days in a week, three weeks.~Radiotherapy with daily image guidance with cone beam-CT or kV-portal position verification."

Trial Locations (1)

02-781

The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Warsaw

All Listed Sponsors
lead

Maria Sklodowska-Curie National Research Institute of Oncology

OTHER

NCT04398095 - Radiotherapy With Hyperthermia in Recurrent and Radiation-Induced Sarcomas | Biotech Hunter | Biotech Hunter