A Study of Sigvotatug Vedotin in Advanced Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

1,006

Participants

Timeline

Start Date

June 8, 2020

Primary Completion Date

June 16, 2027

Study Completion Date

March 22, 2029

Conditions
Carcinoma, Non-Small Cell LungSquamous Cell Carcinoma of Head and NeckHER2 Negative Breast NeoplasmsEsophageal Squamous Cell CarcinomaEsophageal AdenocarcinomaGastroesophageal Junction AdenocarcinomaOvarian NeoplasmsCutaneous Squamous Cell CancerExocrine Pancreatic AdenocarcinomaUrinary Bladder NeoplasmsUterine Cervical NeoplasmsStomach Neoplasms
Interventions
DRUG

sigvotatug vedotin

Administered into the vein (IV; intravenously)

DRUG

pembrolizumab

200mg every 3 weeks or 400mg every 6 weeks, given by IV

DRUG

cisplatin

75 mg/m2 every 3 weeks, given by IV

DRUG

carboplatin

AUC 5 mg/mL per min every 3 weeks, given by IV

Trial Locations (133)

1011

RECRUITING

University Hospital Lausanne CHUV, Lausanne

7000

RECRUITING

Kantonsspital Graubunden, Chur

10028

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, New York

10032

RECRUITING

Columbia University Irving Medical Center, New York

10407

RECRUITING

Hospital Universitario De Jerez, Jerez de la Frontera

RECRUITING

UGC Farmacia Ensayos clinicos - Hospital Universitario de Jerez, Jerez de la Frontera

10408

RECRUITING

National Cancer Center, Goyang-si

10469

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, The Bronx

11042

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, New Hyde Park

11210

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Brooklyn

11217

RECRUITING

Taipei Veterans General Hospital., Taipei

11407

RECRUITING

Hospital Universitario de Jerez, Jerez de la Frontera

11702

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Babylon

11772

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Patchogue

11776

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Port Jefferson Station

11901

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Riverhead

11967

RECRUITING

North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Shirley

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

28034

RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

RECRUITING

Servicio de Radiologia Hospital Universitario Ramon y Cajal, Madrid

28041

NOT_YET_RECRUITING

Hospital Universitario 12 de Octubre, Madrid

NOT_YET_RECRUITING

Hospital Universitario 12 Octubre, Madrid

28050

RECRUITING

Farmacia Ensayos Hospital HM Universitario Sanchinarro, Madrid

RECRUITING

Hospital HM Sanchinarro, START-Madrid-CIOCC, Madrid

28644

RECRUITING

Chungbuk National University Hospital, Cheongju-si

32827

RECRUITING

Florida cancer Specialists, Orlando

33021

RECRUITING

Memorial Cancer Institute, Hollywood

RECRUITING

Memorial Healthcare System, Hollywood

33028

RECRUITING

Memorial Hospital West, Pembroke Pines

39008

RECRUITING

Equipo de Farmacia Oncológica- Ensayos Clínicos Servicio de Farmacia Hospital Universitario Marqués, Santander

44106

ACTIVE_NOT_RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

46219

RECRUITING

Community Health Network, Inc, Indianapolis

46227

RECRUITING

Community Health Network, Indianapolis

46250

RECRUITING

Community Health Network Investigational Drug Services, Indianapolis

RECRUITING

Community Health Network, Indianapolis

46307

RECRUITING

UChicago Medicine - Northwest Indiana, Crown Point

46804

NOT_YET_RECRUITING

Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne

49100

RECRUITING

Center Hospitalier Universitaire d' Angers, Angers

54519

NOT_YET_RECRUITING

Institut de Cancérologie de Lorraine, Moselle

55102

RECRUITING

Allina Health Cancer Institute, Saint Paul

55407

RECRUITING

Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis

55433

RECRUITING

Allina Health Cancer Institute - Mercy Hospital, Coon Rapids

57104

RECRUITING

Sanford Cancer Center, Sioux Falls

57105

RECRUITING

Sanford USD Medical Center, Sioux Falls

60409

RECRUITING

Ingalls Family Care Center, Calumet City

60422

RECRUITING

UChicago Medicine at Ingalls - Flossmoor, Flossmoor

60426

RECRUITING

UChicago Medicine Ingalls Memorial, Harvey

60451

RECRUITING

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox

60462

RECRUITING

The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park

60477

RECRUITING

UChicago Medicine at Ingalls - Tinley Park, Tinley Park

60611

RECRUITING

UChicago Medicine - River East, Chicago

60637

RECRUITING

University of Chicago Medical Center, Chicago

62702

RECRUITING

Southern Illinois University - Simmons Cancer Institute, Springfield

NOT_YET_RECRUITING

Springfield Clinic Radiology - 800 Building, Springfield

NOT_YET_RECRUITING

Springfield Clinic, Springfield

62703

NOT_YET_RECRUITING

Springfield Clinic Radiology - Main Campus, Springfield

66160

RECRUITING

The University of Kansas Hospital, Kansas City

RECRUITING

The University of Kansas Medical Center Medical Office Building, Kansas City

RECRUITING

University of Kansas Hospital Cambridge North Tower A, Kansas City

66205

RECRUITING

The University of Kansas Cancer Center, Investigational Drug Services, Fairway

RECRUITING

The University of Kansas Clinical Research Center, Fairway

RECRUITING

The University of Kansas Cancer Center - Westwood, Westwood

RECRUITING

University of Kansas Cancer Center, Westwood

66211

RECRUITING

The University of Kansas Cancer Center - Indian Creek Campus, Overland Park

72703

RECRUITING

Highlands Oncology Group, Fayetteville

72758

RECRUITING

Highlands Oncology Group, Rogers

72762

RECRUITING

Highlands Oncology Group, Springdale

73104

NOT_YET_RECRUITING

OU Health University of Oklahoma Medical Center, Oklahoma City

NOT_YET_RECRUITING

Stephenson Cancer Center (chemo location), Oklahoma City

NOT_YET_RECRUITING

University of Oklahoma Health Science Center, Oklahoma City

75063

RECRUITING

US Oncology Investigational Product Center (IPC), Irving

75701

NOT_YET_RECRUITING

UT Health East Texas HOPE Cancer Center, Tyler

75708

NOT_YET_RECRUITING

UT Health East Texas Hope Cancer Center, Tyler

77024

RECRUITING

Oncology Consultants, PA, Houston

77030

RECRUITING

Oncology Consultants, PA., Houston

RECRUITING

The University of Texas M.D. Anderson Cancer Center, Houston

77581

NOT_YET_RECRUITING

Houston Medical Imaging, Pearland

77598

NOT_YET_RECRUITING

Tranquil Clinical Research, Webster

78229

ACTIVE_NOT_RECRUITING

South Texas Accelerated Research Therapeutics, LLC, San Antonio

80756

RECRUITING

Kaohsiung Medical University Hospital, Kaohsiung City

86021

RECRUITING

Centre Hospitalier Universitaire de Poitiers, Poitiers

89169

RECRUITING

Comprehensive Cancer Centers of Nevada, Las Vegas

90095

RECRUITING

Ronald Reagan UCLA Medical Center, Los Angeles

RECRUITING

UCLA Department of Medicine-Hematology/Oncology, Los Angeles

90404

RECRUITING

UCLA Department of Medicine - Hematology & Oncology, Santa Monica

90505

NOT_YET_RECRUITING

Cancer AND Blood Specialty Clinic, Torrance

90720

NOT_YET_RECRUITING

Cancer and Blood Research Center, LLC, Los Alamitos

NOT_YET_RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

92835

RECRUITING

Providence Medical Foundation, Fullerton

RECRUITING

Providence St. Jude Medical Center Virginia K Crosson and Infusion Center, Fullerton

97213

RECRUITING

Providence Cancer Institute Franz Clinic, Portland

97225

RECRUITING

Providence Oncology and Hematology Care Clinic - Westside, Portland

RECRUITING

Providence St. Vincent Medical Center- Investigational Drug Services, Portland

RECRUITING

Providence St. Vincent Medical Center, Portland

98026

RECRUITING

Swedish Cancer Institute - Edmonds Campus, Edmonds

RECRUITING

Swedish Cancer Institute Edmonds Campus, Edmonds

98104

RECRUITING

Swedish Cancer Institute, Seattle

98122

RECRUITING

Swedish Medical Center, Seattle

98405

NOT_YET_RECRUITING

Northwest Medical Specialities, PLLC, Tacoma

98502

RECRUITING

American Oncology Network Vista Oncology Division-West office, Olympia

98506

RECRUITING

American Oncology Network Vista Oncology Division-East office, Olympia

99508

NOT_YET_RECRUITING

Alaska Oncology and Hematology, Anchorage

129004

RECRUITING

Quironsalud Malaga, Málaga

02215

RECRUITING

Beth Israel Deaconess Medical Center,East Campus Research Pharmacy, Boston

RECRUITING

Beth Israel Deaconess Medical Center, Boston

02459

RECRUITING

Dana-Farber Cancer Institute - Chestnut Hill, Newton

06189

RECRUITING

Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne, Nice

94805.

RECRUITING

lnstitut Gustave Roussy, Departement d'lnnovation Therapeutique et d'Essais Precoces (DITEP), Villejuif

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

06351

NOT_YET_RECRUITING

Samsung Medical Center, Seoul

06591

RECRUITING

The Catholic University of Korea, Seoul

07061

NOT_YET_RECRUITING

Seoul National University Boramae Medical Center, Seoul

08308

NOT_YET_RECRUITING

Korea University Guro Hospital, Seoul

03203

RECRUITING

Elche General University Hospital, Elche

RECRUITING

Elche General University Hospital, Elche

08023

RECRUITING

Hospital HM Nou Delfos, Barcelona

RECRUITING

NEXT Oncology Barcelona - IOB - Hospital Quironsalud Barcelona, Barcelona

RECRUITING

Farmacia Ensayos clínicos, Unidad START Barcelona, Barcelona

RECRUITING

Hospital HM Nou Delfos - START Barcelona, Barcelona

RECRUITING

Hospital Quiron Salud Barcelona, Barcelona

Unknown

RECRUITING

"Area general-Planta Baixa , Unitat d'investigacio en terapia Molecular del Cancer la Caixa"

08035

RECRUITING

Hospital Vall d'Hebron, Barcelona

CH-1011

RECRUITING

CHUV - Service de pharmacie BH-04, Essais cliniques, Lausanne

100, R.O.C

NOT_YET_RECRUITING

National Taiwan University Hospital, Taipei

SM2 5PT

RECRUITING

The Royal Marsden Hospital (Surrey), Sutton

RECRUITING

Royal Marsden Hospital, Sutton

B15 2TH

RECRUITING

Queen Elizabeth Hospital, Birmingham

RECRUITING

University Hospitals Birmingham NHS Foundation Trust, Birmingham

SW3 6JJ

RECRUITING

The Royal Marsden NHS Foundation Trust, London

W1G 6AD

RECRUITING

Sarah Cannon Research Institute, London

W1G 7AF

RECRUITING

Diagnostic centre, London

W1G 8BJ

RECRUITING

The Harley Street Clinic, London

W1G 8PP

RECRUITING

Radiology, London

All Listed Sponsors
lead

Seagen, a wholly owned subsidiary of Pfizer

INDUSTRY