Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

440

Participants

Timeline

Start Date

September 16, 2020

Primary Completion Date

June 23, 2025

Study Completion Date

June 30, 2028

Conditions
Relapsed Diffuse Large B-Cell LymphomaRefractory Diffuse Large B-Cell Lymphoma
Interventions
DRUG

Loncastuximab Tesirine

Intravenous Infusion

DRUG

Rituximab

Intravenous Infusion

DRUG

Gemcitabine

Intravenous Infusion

DRUG

Oxaliplatin

Intravenous Infusion

Trial Locations (144)

1088

Semmelweis Egyetem, Budapest

1097

Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet - Szent László, Budapest

1120

Boca Raton Clinical Research (BRCR) Global Mexico - Ciudad de México, Mexico City

1122

Orszagos Onkologiai Intezet, Budapest

1200

Cliniques Universitaires Saint-Luc, Brussels

3000

Clínica de Nefrología, Urología y Enfermedades Cardiovasculares S.A., Santa Fe

3300

Heves Varmegyei Markhot Ferenc Oktatokorhaz es Rendelointezet, Heves

6500

Istituto Oncologico della Svizzera Italiana, Bellinzona

6510

Özel Koru Hastanesi, Çukurambar

8000

Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan, Bruges

8800

Algemeen Ziekenhuis Delta - Campus Rumbeke, Roeselare

10003

Hospital San Pedro de Alcantara, Cáceres

20089

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas, Milan

20132

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele, Milan

20141

Istituto Europeo di Oncologia, Milan

20155

Virginia Cancer Specialists, Gainesville

21000

Hôpital François Mitterrand, Dijon

25123

Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia, Brescia

25198

Hospital Arnau de Vilanova, Valencia

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

29200

Centre Hospitalier Regional Universitaire Brest, Brest

Centre Hospitalier Regional Universitaire Brest, Brest

29425

Hollings Cancer Center, Charleston

32207

Baptist MD Anderson Cancer Center, Jacksonville

33100

Presidio Ospedaliero Universitario Santa Maria della Misericordia, Udine

33604

Hôpital Haut-Lévêque, Pessac

34365

VKV Amerikan Hastanesi, Şişli

35100

Ege Universitesi Tip Fakultesi Hastanesi, Bornova

38039

Mehmet Kemal Dedeman Hematoloji Hastanesi, Kayseri

39008

Hospital Universitario Marqués de Valdecilla, Santander

40207

Norton Cancer Institute, Louisville

41013

Hospital Universitario Virgen del Rocío, Seville

44200

Hôpital Privé du Confluent, Nantes

44600

Boca Raton Clinical Research (BRCR) Global Mexico - Guadalajara, Guadalajara

44670

PanAmerican Clinical Research Mexico - Guadalajara, Guadalajara

47014

"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST", Meldola

48121

Sanitaria Locale della Romagna, Ravenna

50134

Azienda Ospedaliero - Universitaria Careggi, Florence

50309

UnityPoint Health - Iowa Oncology Research Association (IORA), Des Moines

52621

The Chaim Sheba Medical Center, Tel Aviv

52787

Hematológica Alta Especialidad, Huixquilucan

53226

Medical College of Wisconsin Cancer Center Clinical Trials Office, Milwaukee

55270

Ondokuz Mayis Üniversitesi, Kurupelit

61080

Karadeniz Teknik Üniversitesi Tip Fakültesi, Ortahisar

62290

PanAmerican Clinical Research Mexico - Cuernavaca, Cuernavaca

64460

Hospital Universitario Dr. José Eleuterio González, Monterrey

71013

Ospedale Casa Sollievo della Sofferenza, Foggia

75651

Hopital Universitaire Pitie Salpetriere, Paris

76038

Centre de Lutte Contre le Cancer - Centre Henri-Becquerel, Rouen

89169

Comprehensive Cancer Centers of Nevada - Henderson, Las Vegas

90603

The Oncology Institute of Hope and Innovation, Whittier

92093

University of California San Diego Moores Cancer Center, La Jolla

92373

Redlands Community Hospital, Redlands

93000

Hôpital Avicenne, Bobigny

97227

Kaiser Permanente Interstate Medical Office Central, Portland

100191

Peking University Third Hospital, Beijing

116000

Second Affiliated Hospital of Dalian Medical University, Dalian

130021

Jilin Cancer Hospital, Changchun

The First Hospital of Jilin University, Changchun

200025

Shanghai Cancer Center, Shanghai

300020

Institute of Hematology and Blood Diseases Hospital of CAMS - PUMC, Tianjin

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

310003

The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

361001

The First Affiliated Hospital of Xiamen University, Xiamen

400030

Chongqing University Cancer Hospital - Chongqing Cancer Hospital, Chongqing

430023

Wuhan Union Hospital, Wuhan

430030

Tongji Hospital, Wuhan

450008

Henan Cancer Hospital - Zhengzhou University, Zhengzhou

510060

Sun Yat-Sen University Cancer Center, Guangzhou

510080

Guangdong Provincial People's Hospital, Guangzhou

510280

Zhujiang Hospital of Southern Medical University, Guangzhou

516001

Huizhou Municipal Central Hospital, Huizhou

610041

West China School of Medicine - West China Hospital of Sichuan University, Chengdu

3436212

Carmel Medical Center, Haifa

4941492

Rabin Medical Center - Beilinson Hospital, Petah Tikva

6423906

Tel Aviv Sourasky Medical Center, Tel Aviv

7030000

Shamir Medical Center (Assaf Harofeh), Be’er Ya‘aqov

7500653

Centro de Estudios Clínicos SAGA, Santiago

7747629

Samson Assuta Ashdod University Hospital, Ashdod

8320000

Instituto Oncológico Fundación Arturo López Pérez, Santiago

8330109

CeCim - Centro de Estudios Clínicos e Investigaciones Médicas, Santiago

8410101

Soroka Medical Center, Beersheba

C1430EGF

Clinica Adventista Belgrano, Belgrano

C1426ANZ

Instituto Médico Especializado Alexander Fleming, Buenos Aires

S2000GAP

Grupo Gamma - Hospital Privado Rosario, Rosario

B-5530

Centre Hospitalier Universitaire Universite Catholique de Louvain, Namur

81520-060

Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba

90035-001

Hospital Moinhos de Vento, Porto Alegre

90035-903

Hospital de Clínicas de Porto Alegre, Porto Alegre

90110-270

Hospital Mãe de Deus - Centro Integrado de Oncologia, Porto Alegre

20230-130

Hospital do Câncer, Rio de Janeiro

01236-030

Hemomed Instituto de Oncologia e Hematologia, São Paulo

01321-001

A Beneficência Portuguesa de São Paulo - Unidade Mirante, São Paulo

05403-010

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo

05652-900

Hospital Israelita Albert Einstein, São Paulo

08270-120

Hospital Santa Marcelina, São Paulo

T6G 1Z2

Cross Cancer Institute, Edmonton

H4A 3J1

Research Institute of the McGill University Health Centre, Montreal

J1H 5H3

Hôpital Fleurimont, Sherbrooke

708 52

Fakultni nemocnice Ostrava, Ostrava

100 34

Fakultni Nemocnice Kralovske Vinohrady, Prague

150 06

Fakultni nemocnice v Motole, Prague

460-0001

National Hospital Organization - Nagoya Medical Center, Nagoya

441-8570

Toyohashi Municipal Hospital, Toyohashi

277-8577

National Cancer Center Hospital East, Kashiwa

790-8524

Matsuyama Red Cross Hospital, Matsuyama

373-8550

Gunma Prefectural Cancer Center, Ōta

003-0006

Sapporo Hokuyu Hospital, Sapporo

003-0804

Hokkaido Cancer Center, Sapporo

650-0047

Kobe City Medical Center General Hospital, Kobe

241-8515

Kanagawa Cancer Center, Yokohama

980-8574

Tohoku University Hospital, Sendai

852-8501

Nagasaki University Hospital, Nagasaki

350-1298

Saitama Medical University - International Medical Center, Hidaka-Shi

113-8677

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo-ku

190-0014

National Hospital Organization Disaster Medical Center, Tachikawa

960-1295

Fukushima Medical University Hospital, Fukushima

500-8323

Gifu Municipal Hospital, Gifu

890-8520

Kagoshima University Hospital, Kagoshima

951-8520

Niigata University Medical and Dental Hospital, Niigata

701-1192

National Hospital Organization Okayama Medical Center, Okayama

541-8567

Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka

2545 AA

Hagaziekenhuis Van Den Haag - Leyweg, The Hague

5022 GC

Elisabeth-TweeSteden Ziekenhuis - Elisabeth, Tilburg

30-510

Pratia MCM Kraków, Krakow

50-367

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wroclaw

81-519

Szpitale Pomorskie Spółka Z Ograniczoną Odpowiedzialnością, Gdynia

40-519

Pratia Onkologia Katowice, Katowice

93-510

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz

45-061

Szpital Wojewódzki w Opolu, Opole

60-185

Centrum Medyczne Pratia Poznań, Skorzewo

02-776

Instytut Hematologii I Transfuzjologii, Warsaw

00919

Hospital Español Auxilio Mutuo, San Juan

08003

Hospital del Mar - Parc de Salut Mar, Barcelona

08908

Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), Barcelona

06100

Ankara Universitesi Tip Fakultesi - Cebeci Arastirma ve Uygulama Hastanesi, Ankara

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

G12 0XH

NHS Greater Glasgow and Clyde, Glasgow

M20 4BX

The Christie NHS Foundation Trust, Manchester

Sponsors
All Listed Sponsors
lead

ADC Therapeutics S.A.

INDUSTRY