TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis

EARLY_PHASE1RecruitingINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

February 24, 2022

Primary Completion Date

December 22, 2026

Study Completion Date

December 22, 2026

Conditions

Systemic Scleroderma

Interventions

PROCEDURE

Allogeneic Hematopoietic Stem Cell Transplantation

Undergo HSCT

DRUG

Cyclophosphamide

Undergo HSCT

RADIATION

Intensity-Modulated Radiation Therapy

Undergo TBI using IMRT

PROCEDURE

Total-Body Irradiation

Undergo TBI using IMRT

Trial Locations (1)

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER