870
Participants
Start Date
July 6, 2020
Primary Completion Date
July 6, 2026
Study Completion Date
February 15, 2027
Pembrolizumab
intravenous (IV) infusion
Olaparib
oral tablets
Placebo for olaparib
oral tablets
Etoposide
IV infusion
Carboplatin
IV infusion
Cisplatin
IV infusion
Paclitaxel
IV infusion
Pemetrexed
IV infusion
Thoracic Radiotherapy
external beam radiation
Durvalumab
IV infusion
Pauls Stradins Clinical University Hospital ( Site 1501), Riga
Riga East Clinical University Hospital ( Site 1500), Riga
Orszagos Koranyi Pulmonologiai Intezet ( Site 2305), Budapest
Országos Korányi Pulmonológiai Intézet-VI. Tüdöbelosztály és Bronchológia ( Site 2309), Budapest
Akershus Universitetssykehus HF ( Site 1106), Lorenskog
Sykehuset Oestfold ( Site 1107), Grålum
Vestre Viken HF Drammen Sykehus ( Site 1101), Drammen
Helse Stavanger HF Stavanger Universitetssjukehus ( Site 1103), Stavanger
Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 2303), Gyula
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2302), Kecskemét
Petz Aladar Megyei Oktato Korhaz ( Site 2306), Győr
Chulalongkorn University ( Site 3003), Bangkok
Ramathibodi Hospital. ( Site 3000), Bangkok
National Cancer Center ( Site 2800), Goyang-si
Montefiore Einstein Center ( Site 0083), The Bronx
Clinique Clairval ( Site 0802), Marseille
Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum ( Site 0900), Berlin
North Estonia Medical Centre Foundation ( Site 1601), Tallinn
Seoul National University Bundang Hospital ( Site 2801), Seongnam-si
Instituto Nacional de Cancerologia ( Site 0502), Tlalpan
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0606), Lima
Oncosalud ( Site 0605), Lima
Detecta Clínica ( Site 0607), Surquillo
Clinica San Gabriel ( Site 0601), Lima
Hospital Nacional Cayetano Heredia ( Site 0602), Lima
The Catholic University of Korea St. Vincent s Hospital ( Site 2805), Suwon
Ajou University Hospital ( Site 2803), Suwon
Fox Chase Cancer Center ( Site 0063), Philadelphia
Istituto Clinico Humanitas Research Hospital ( Site 1000), Rozzano
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1008), Milan
Katholisches Marienkrankenhaus gGmbH ( Site 0902), Hamburg
LungenClinic Grosshansdorf GmbH ( Site 0901), Großhansdorf
LLC Ukrainian Center of Tomotherapy ( Site 2105), Kropyvnytskyi
Piedmont Hematology-Oncology Associates ( Site 0080), Winston-Salem
Duke University Medical Center ( Site 0050), Durham
Novant Health Presbyterian ( Site 0081), Charlotte
Hospital Universitario Puerta de Hierro (Majadahonda) ( Site 1202), Majadahonda
Hospital Universitario Quiron Madrid ( Site 1200), Pozuelo de Alarcón
Chungbuk National University Hospital ( Site 2802), Cheongju-si
H.R.U Malaga - Hospital General ( Site 1206), Málaga
C.H.R.U. de Brest - Hopital Cavale Blanche ( Site 0806), Brest
Johannes Wesling Klinikum Minden ( Site 0908), Minden
Mid Florida Hematology and Oncology Center ( Site 0022), Orange City
Orlando Health, UF Health Cancer Center Inc ( Site 0092), Orlando
Memorial Regional Hospital-Memorial Cancer Institute ( Site 0095), Hollywood
A.O.U. Santa Maria della Misericordia di Udine ( Site 1004), Udine
Miami VA Healthcare System ( Site 0024), Miami
Istanbul Uni. Cerrahpasa Tip Fakultesi ( Site 2000), Istanbul
Medipol Universite Hastanesi ( Site 2003), Istanbul
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2001), Istanbul
Ege University Medical Faculty ( Site 2005), Izmir
University of South Alabama, Mitchell Cancer Institute ( Site 0003), Mobile
Universitätsmedizin Göttingen - Georg-August-Universität ( Site 0917), Göttingen
Srinagarind Hospital. Khon Kaen University ( Site 3002), Khon Kaen
Norton Brownsboro Hospital-Norton Cancer Institute - Brownsboro ( Site 0035), Louisville
University of Kentucky ( Site 0096), Lexington
Hospital Universitario Virgen Macarena ( Site 1205), Seville
Policlinico di Modena ( Site 1007), Modena
Johanna Etienne Hospital-Klinik für Onkologie ( Site 0916), Neuss
Pikeville Medical Center ( Site 0036), Pikeville
Keimyung University Dongsan Hospital CRC room 1 ( Site 2807), Daegu
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0500), Guadalajara
The Lindner Center for Research and Education at The Christ Hospital ( Site 0060), Cincinnati
Hospital Universitario La Fe ( Site 1203), Valencia
Fort Wayne Medical Oncology and Hematology ( Site 0094), Fort Wayne
Parkview Research Center ( Site 0032), Fort Wayne
Franciscan Health Lafayette East ( Site 0031), Lafayette
GEHO Muenster ( Site 0910), Münster
Henry Ford Hospital ( Site 0045), Detroit
Medical center Medikal Plaza of Ecodnipro LLC ( Site 2107), Dnipro
Azienda Ospedaliero Universitaria Careggi ( Site 1001), Florence
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 4201), Kaunas
Chiang Mai University Maharaj Nakorn Chiang Mai Hospital ( Site 3001), Chiang Mai
Tartu University Hospital ( Site 1600), Tartu
Gyeongsang National University Hospital ( Site 2804), Jinju
Sanford Cancer Center Oncology Clinic ( Site 0066), Sioux Falls
Clinique Teissier Groupe ( Site 0808), Valenciennes
Azienda Ospedaliera Umberto I- Torrette ( Site 1009), Torrette
SOGrigoriev Inst for Med Radiolgy and Oncology of NAMS of Ukraine-Clinical oncology and hematology ( Site 2110), Kharkiv
VA St. Louis Health Care System ( Site 0047), St Louis
Washington University Siteman Cancer Center ( Site 0046), St Louis
"Hospital Universitario Dr. Jose Eleuterio Gonzalez ( Site 0508)", Monterrey
CHI Health St. Francis ( Site 0053), Grand Island
St. Bernards Medical Center ( Site 0089), Jonesboro
"Communal nonprofit enterprise Kherson Regional Oncology Dispensary of Kherson Regional Council ( Site 2109)", Antonivka Village
Azienda Ospedaliera Vito Fazzi ( Site 1003), Lecce
Centre Hospitalier Annecy Genevois ( Site 0811), Epagny Metz Tessy
Clinique de l'Europe-Service de pneumologie ( Site 0816), Amiens
H.I.A. Sainte-Anne ( Site 0815), Toulon
CHD Vendee ( Site 0807), La Roche-sur-Yon
UCLA Hematology/Oncology - Santa Monica ( Site 0013), Los Angeles
Torrance Memorial Physician Network / Cancer Center ( Site 0093), Torrance
Long Beach Memorial Medical Center ( Site 0006), Long Beach
St Joseph Heritage Healthcare-Oncology ( Site 0088), Fullerton
Hopital Avicenne ( Site 0803), Bobigny
CLIMERS Clinical Medical Research ( Site 0506), Orizaba
St. Joseph Heritage Healthcare Local Lab ( Site 0011), Santa Rosa
Veterans Affairs Puget Sound Health Care System [Seattle, WA] ( Site 0075), Seattle
Cancer Care Northwest ( Site 0074), Spokane Valley
Zentralklinik Bad Berka GmbH ( Site 0905), Bad Berka
Peking Union Medical College Hospital ( Site 3201), Beijing
Cancer Hospital Chinese Academy of Medical Sciences ( Site 3213), Beijing
Beijing Cancer Hospital ( Site 3212), Beijing
MSROI named after P.A. Hertsen branch of FSBI NMRC Radiology ( Site 1903), Moscow
Jilin Cancer Hospital ( Site 3230), Changchun
Beijing Cancer Hospital ( Site 3224), Beijing
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1910), Yaroslavl
Medical institute named after Berezin Sergey ( Site 1906), Saint Petersburg
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1905), Saint Petersburg
Shanghai Chest Hospital ( Site 3207), Shanghai
Zhongshan Hospital Fudan University ( Site 3220), Shanghai
Shanghai Pulmonary Hospital ( Site 3203), Shanghai
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2510), Craiova
Jiangsu Cancer Hospital ( Site 3234), Nanjing
Tianjin Medical University Cancer Institute & Hospital ( Site 3204), Tianjin
S C Oncocenter Oncologie Clinica S R L-Medical Oncology ( Site 2509), Timișoara
Policlinica Oncomed SRL ( Site 2504), Timișoara
The 1st Affil Hosp of College of Medicine, Zhejiang Univ ( Site 3232), Hangzhou
The Second Affiliated Hospital of Nanchang University ( Site 3206), Nanchang
Fujian Provincial Cancer Hospital ( Site 3226), Fuzhou
The First Affiliated Hospital of Xiamen University ( Site 3219), Xiamen
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2506), Cluj-Napoca
Daping Hospital,Third Military Medical University ( Site 3235), Chongqing
S.C. Radiotherapy Center Cluj S.R.L ( Site 2503), Comuna Floresti
Xiangya Hospital of Central South University ( Site 3637), Changsha
Second Xiangya Hospital of Central-South University ( Site 3227), Changsha
Hunan Cancer Hospital ( Site 3225), Changsha
Hunan Cancer Hospital ( Site 3238), Changsha
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 1911), Kazan'
Wuhan Union Hospital Cancer Center ( Site 3222), Wuhan
Hubei Cancer Hospital ( Site 3218), Wuhan
Henan Cancer Hospital ( Site 3205), Zhengzhou
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1913), Chelyabinsk
West China Hospital of Sichuan University ( Site 3202), Chengdu
Peking University Shenzhen Hospital ( Site 3216), Shenzhen
Cancer Hospital Chinese Academy Of Medical Sciences. Shenzhen Center ( Site 3200), Shenzhen
Nizhniy Novgorod Region Oncology Dispensary ( Site 1914), Nizhny Novgorod
Sverdlovsk Regional Oncology Hospital ( Site 1909), Yekaterinburg
Institutul Regional de Oncologie Iasi ( Site 2505), Iași
Spitalul Clinic Judetean De Urgenta Constanta ( Site 2501), Constanța
Bradford Hill Norte ( Site 0204), Antofagasta
Oncocentro ( Site 0203), Viña del Mar
Centro Investigación del Cáncer James Lind ( Site 0202), Temuco
OrlandiOncologia ( Site 0201), Providencia
Bradfordhill ( Site 0200), Santiago
Massachusetts General Hospital ( Site 0038), Boston
Rutgers Cancer Institute of New Jersey ( Site 0054), New Brunswick
Valley Health Systems - Ridgewood Campus ( Site 0056), Paramus
Clinica Adventista Belgrano-Oncology ( Site 4002), Caba.
Instituto Médico Río Cuarto ( Site 4003), Río Cuarto
Queen Elizabeth II Health Sciences Centre ( Site 0100), Halifax
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0102), Montreal
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0108), Montreal
McGill University Health Center - Research Institute ( Site 0114), Montreal
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0110), Québec
Masarykuv onkologicky ustav ( Site 2206), Brno
Fakultni nemocnice Ostrava ( Site 2201), Ostrava
Fakultni nemocnice Kralovske Vinohrady-Radioterapeuticka a onkologicka klinika ( Site 2200), Prague
Fakultni nemocnice v Motole ( Site 2210), Prague
Nemocnice Na Plesi s.r.o. ( Site 2202), Nová Ves pod Pleší
Krajska nemocnice Liberec, a.s. ( Site 2209), Liberec
Vseobecna fakultni nemocnice v Praze ( Site 2208), Prague
Nemocnice Na Bulovce ( Site 2205), Prague
Universitaetsklinikum Jena ( Site 0911), Jena
Policlinico Agostino Gemelli ( Site 1002), Rome
Kurume University Hospital ( Site 3112), Kurume
Kobe Minimally Invasive Cancer Center ( Site 3100), Kobe
Kanagawa Cancer Center ( Site 3101), Yokohama
Kansai Medical University Hospital ( Site 3103), Hirakata
Osaka Medical and Pharmaceutical University Hospital ( Site 3110), Takatsuki
National Hospital Organization Kyushu Cancer Center ( Site 3104), Fukuoka
Niigata Cancer Center Hospital ( Site 3109), Niigata
Osaka International Cancer Institute ( Site 3106), Osaka
Juntendo University Hospital ( Site 3111), Tokyo
Tokyo Metropolitan Komagome Hospital ( Site 3108), Tokyo
Cancer Institute Hospital of JFCR ( Site 3107), Tokyo
Showa Medical University Hospital ( Site 3105), Tokyo
National Cancer Institute-Department of Thoracic Surgery and Oncology ( Site 4200), Vilnius
Oslo Universitetssykehus HF. Ulleval ( Site 1100), Oslo
Hospital Nacional Carlos Alberto Seguin Escobedo ESSALUD ( Site 0604), Arequipa
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2404), Siedlce
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2402), Warsaw
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 2400), Gdynia
SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2401), Olsztyn
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2500), Bucharest
Gral Medical SRL-Medical Oncology ( Site 2511), Bucharest
Spitalul Universitar de Urgenta Bucuresti ( Site 2508), Bucharest
Radiology Therapeutic Center-Oncology ( Site 2502), Otopeni
Kangbuk Samsung Hospital ( Site 2806), Seoul
Severance Hospital Yonsei University Health System ( Site 2808), Seoul
H.U. Vall de Hebron ( Site 1201), Barcelona
Hospital Clinic de Barcelona ( Site 1204), Barcelona
Ankara Bilkent Sehir Hastanesi ( Site 2002), Ankara
Memorial Ankara Hastanesi ( Site 2006), Ankara
Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 2104), Kapitanivka Village
SNPE National Cancer Institute ( Site 2101), Kyiv
Medical Center Verum ( Site 2106), Kyiv
Kyiv City Clinical Oncology Center ( Site 2100), Kyiv
Weston Park Hospital ( Site 1406), Sheffield
Guys and St Thomas NHS Foundation Trust ( Site 1410), London
University College Hospital NHS Foundation Trust ( Site 1403), London-Camden
Royal Marsden Hospital (Sutton) ( Site 1407), London
Southampton General Hospital ( Site 1400), Southampton
Leeds Teaching Hospitals NHS Trust ( Site 1401), Leeds
Christie NHS Foundation Trust ( Site 1409), Manchester
Merck Sharp & Dohme LLC
INDUSTRY