NCT04379596 - Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03) | Biotech Hunter

Enrollment

413

Participants

Timeline

Start Date

June 3, 2020

Primary Completion Date

June 1, 2027

Study Completion Date

June 1, 2027

Conditions

Gastric Cancer

Interventions

DRUG

Fluorouracil (5-FU)

5-FU: administered as an IV infusion

DRUG

Capecitabine

Capecitabine: administered orally

BIOLOGICAL

Durvalumab

Durvalumab: administered as an IV infusion

DRUG

Oxaliplatin

Oxaliplatin: administered as an IV infusion

BIOLOGICAL

Trastuzumab

Trastuzumab: administered as an IV infusion

DRUG

Trastuzumab deruxtecan

T-DXd: administered as an IV infusion

DRUG

Cisplatin

Cisplatin: administered as an IV infusion

BIOLOGICAL

Pembrolizumab

Pembrolizumab: administered as an IV infusion

BIOLOGICAL

Volrustomig

Volrustomig: administered as an IV infusion

BIOLOGICAL

Rilvegostomig

Rilvegostomig: administered as an IV infusion

Trial Locations (100)

333

RECRUITING

Research Site, Taoyuan District

704

RECRUITING

Research Site, Tainan City

10002

RECRUITING

Research Site, Taipei

10065

RECRUITING

Research Site, New York

11217

RECRUITING

Research Site, Taipei

13620

RECRUITING

Research Site, Seongnam-si

20133

RECRUITING

Research Site, Milan

20162

RECRUITING

Research Site, Milan

20249

RECRUITING

Research Site, Hamburg

21287

RECRUITING

Research Site, Baltimore

22031

WITHDRAWN

Research Site, Fairfax

27710

WITHDRAWN

Research Site, Durham

28007

RECRUITING

Research Site, Madrid

28034

RECRUITING

Research Site, Madrid

35128

RECRUITING

Research Site, Padua

37134

RECRUITING

Research Site, Verona

39008

RECRUITING

Research Site, Santander

41013

RECRUITING

Research Site, Seville

48109

WITHDRAWN

Research Site, Ann Arbor

60488

RECRUITING

Research Site, Frankfurt

60590

RECRUITING

Research Site, Frankfurt

66205

WITHDRAWN

Research Site, Westwood

68167

RECRUITING

Research Site, Mannheim

77090

RECRUITING

Research Site, Houston

80131

RECRUITING

Research Site, Napoli

80756

RECRUITING

Research Site, Kaohsiung City

81675

RECRUITING

Research Site, München

83301

WITHDRAWN

Research Site, Kaohsiung City

90404

WITHDRAWN

Research Site, Santa Monica

110001

RECRUITING

Research Site, Shenyang

115478

SUSPENDED

Research Site, Moscow

125284

TERMINATED

Research Site, Moscow

143423

SUSPENDED

Research Site, Moscow

143442

TERMINATED

Research Site, Moscow

156005

SUSPENDED

Research Site, Kostroma

195271

COMPLETED

Research Site, Saint Petersburg

196603

SUSPENDED

Research Site, Saint Petersburg

197022

SUSPENDED

Research Site, Saint Petersburg

197758

COMPLETED

Research Site, Saint Petersburg

200025

RECRUITING

Research Site, Shanghai

200031

WITHDRAWN

Research Site, Shanghai

200032

RECRUITING

Research Site, Shanghai

200050

WITHDRAWN

Research Site, Shanghai

230001

RECRUITING

Research Site, Hefei

230601

WITHDRAWN

Research Site, Hefei

310022

WITHDRAWN

Research Site, Hangzhou

361003

WITHDRAWN

Research Site, Xiamen

430000

RECRUITING

Research Site, Wuhan

450008

RECRUITING

Research Site, Zhengzhou

510062

RECRUITING

Research Site, Guangzhou

550002

WITHDRAWN

Research Site, Guiyang

610042

RECRUITING

Research Site, Chengdu

630099

SUSPENDED

Research Site, Novosibirsk

830000

WITHDRAWN

Research Site, Ürümqi

02114

WITHDRAWN

Research Site, Boston

02215

RECRUITING

Research Site, Boston

88020-210

WITHDRAWN

Research Site, Florianópolis

86015-520

RECRUITING

Research Site, Londrina

59075-740

WITHDRAWN

Research Site, Natal

90160-093

WITHDRAWN

Research Site, Porto Alegre

14051-140

ACTIVE_NOT_RECRUITING

Research Site, Ribeirão Preto

22793-080

WITHDRAWN

Research Site, Rio de Janeiro

97015-450

RECRUITING

Research Site, Santa Maria

15090-000

RECRUITING

Research Site, São Jose Do Rio Preto

01509-900

WITHDRAWN

Research Site, São Paulo

03102-002

WITHDRAWN

Research Site, São Paulo

045202-001

ACTIVE_NOT_RECRUITING

Research Site, São Paulo

T6G 1Z2

WITHDRAWN

Research Site, Edmonton

K1H 8L6

WITHDRAWN

Research Site, Ottawa

M4N 3M5

WITHDRAWN

Research Site, Toronto

M5G 2M9

RECRUITING

Research Site, Toronto

H4A 3J1

RECRUITING

Research Site, Montreal

G1J 1Z4

RECRUITING

Research Site, Québec

04103

RECRUITING

Research Site, Leipzig

00168

RECRUITING

Research Site, Roma

104-0045

RECRUITING

Research Site, Chūōku

277-8577

RECRUITING

Research Site, Kashiwa

761-0793

RECRUITING

Research Site, Kita-gun

373-8550

RECRUITING

Research Site, Ota-shi

1066CX

ACTIVE_NOT_RECRUITING

Research Site, Amsterdam

1081 HV

ACTIVE_NOT_RECRUITING

Research Site, Amsterdam

3584CG

ACTIVE_NOT_RECRUITING

Research Site, Utrecht

80-214

RECRUITING

Research Site, Gdansk

62-500

RECRUITING

Research Site, Konin

75-581

RECRUITING

Research Site, Koszalin

31-501

RECRUITING

Research Site, Krakow

20-090

WITHDRAWN

Research Site, Lublin

45-061

WITHDRAWN

Research Site, Opole

97-200

WITHDRAWN

Research Site, Tomaszów Mazowiecki

02-034

RECRUITING

Research Site, Warsaw

03080

RECRUITING

Research Site, Seoul

03722

RECRUITING

Research Site, Seoul

05505

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08035

RECRUITING

Research Site, Barcelona

CB2 0QQ

RECRUITING

Research Site, Cambridge

DD1 9SY

RECRUITING

Research Site, Dundee

NW1 2PG

RECRUITING

Research Site, London

M20 4BX

RECRUITING

Research Site, Manchester

SM2 5PT

RECRUITING

Research Site, Sutton