Immunophenotyping Assessment in a COVID-19 Cohort

CompletedOBSERVATIONAL
Enrollment

1,227

Participants

Timeline

Start Date

May 1, 2020

Primary Completion Date

March 19, 2021

Study Completion Date

April 21, 2022

Conditions
Coronavirus Disease 2019 (COVID-19)SARS-CoV-2
Interventions
PROCEDURE

Biological sample collection

During patient hospitalization: Nasal secretion samples by nasal swabs (for non-intubated patients), whole blood (blood draw/phlebotomy) and sputum secretions by endotracheal aspiration (for intubated patients) will be obtained to proceed with immunologic analysis of samples. DNA will be collected from whole blood at enrollment for genetic analysis (e.g., genome-wide association study \[GWAS\]). After hospital discharge: Collection of biologic samples (involving nasal swabs and blood draw/phlebotomy) will occur up to 12 months.

PROCEDURE

Data Collection: Clinical Care Assessments

Baseline data and assessments obtained as part of ongoing clinical care will be collected throughout hospitalization for COVID-19. After hospital discharge, clinical status and activity assessments will occur up to 12 months.

Trial Locations (17)

10029

Icahn School of Medicine at Mount Sinai, New York

19102

Drexel University College of Medicine, Philadelphia

30317

Emory University School of Medicine, Atlanta

32209

University of Florida Health Jacksonville, Jacksonville

32608

University of Florida Health Gainesville, Gainesville

33606

University of South Florida Health Tampa, Tampa

44106

University Hospitals Case Medical Center, Cleveland

73126

University of Oklahoma ,Oklahoma Health Sciences Center: Pulmonary/Critical Care, Department of Medicine, Oklahoma City

77030

Baylor College of Medicine: Department of Medicine, Houston

78712

University of Texas at Austin: UT Health Austin, Austin

85724

University of Arizona (UA) College of Medicine - Tucson: UA Health Sciences Asthma and Airway Disease Research Center, Tucson

90024

University of California, Los Angeles: Department of Medicine, Los Angeles

94115

University of California San Francisco School of Medicine, San Francisco

94305

Stanford Medicine: Sean N. Parker Center for Allergy & Asthma Research, Stanford

97239

Oregon Health & Science University, Portland

06520

Yale School of Medicine, New Haven

02115

Brigham and Women's Hospital, Boston

Sponsors
All Listed Sponsors
collaborator

Benaroya Research Institute

OTHER

collaborator

Boston Children's Hospital

OTHER

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH