A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

PHASE4RecruitingINTERVENTIONAL
Enrollment

952

Participants

Timeline

Start Date

November 3, 2020

Primary Completion Date

September 30, 2028

Study Completion Date

May 31, 2029

Conditions
Opioid Use Disorder
Interventions
DRUG

Sublingual buprenorphine with naloxone

The combination SL-containing buprenorphine contains naloxone in a ratio of 4:1 buprenorphine:naloxone. Participants will be given a 28-prescription at each 28-day visit through Week 48.

DRUG

Injectable subcutaneous buprenorphine

Injectable buprenorphine consists of a depot injectable formulation in polymeric solution and releases buprenorphine over a 28-day (4-week) period by diffusion as the polymer biodegrades. The injection will be administered subcutaneously in the abdomen at each 28-day visit through Week 48.

Trial Locations (25)

15240

TERMINATED

VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh

19106

RECRUITING

Philadelphia MultiService Center, Philadelphia, PA, Philadelphia

23667

RECRUITING

Hampton VA Medical Center, Hampton, VA, Hampton

44106

TERMINATED

Louis Stokes VA Medical Center, Cleveland, OH, Cleveland

45428

RECRUITING

Dayton VA Medical Center, Dayton, OH, Dayton

85012

RECRUITING

Phoenix VA Health Care System, Phoenix, AZ, Phoenix

90822

RECRUITING

VA Long Beach Healthcare System, Long Beach, CA, Long Beach

35404-5015

ACTIVE_NOT_RECRUITING

Tuscaloosa VA Medical Center, Tuscaloosa, AL, Tuscaloosa

94304-1207

RECRUITING

VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto

94121-1563

RECRUITING

San Francisco VA Medical Center, San Francisco, CA, San Francisco

06516-2770

RECRUITING

CERC (VISN1, West Haven, CT), West Haven

ACTIVE_NOT_RECRUITING

VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven

19805-4917

RECRUITING

Wilmington VA Medical Center, Wilmington, DE, Wilmington

33744-0000

RECRUITING

Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines

32608-1135

RECRUITING

North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville

02130

TERMINATED

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston

55417-2309

ACTIVE_NOT_RECRUITING

Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis

02908-4734

ACTIVE_NOT_RECRUITING

Providence VA Medical Center, Providence, RI, Providence

75216-7167

RECRUITING

VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas

84148-0001

RECRUITING

VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City

05001-3833

TERMINATED

White River Junction VA Medical Center, White River Junction, VT, White River Junction

24153-6404

RECRUITING

Salem VA Medical Center, Salem, VA, Salem

98108-1532

RECRUITING

VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle

25704-9300

NOT_YET_RECRUITING

Huntington VA Medical Center, Huntington, WV, Huntington

53295-0001

RECRUITING

Clement J. Zablocki VA Medical Center, Milwaukee, WI, Milwaukee

All Listed Sponsors
lead

VA Office of Research and Development

FED