Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine

PHASE4CompletedINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

May 11, 2020

Primary Completion Date

May 11, 2021

Study Completion Date

July 11, 2021

Conditions
Physiological Effect of DrugsMorphineAnalgesicsAnalgesics, OpioidCentral Nervous System DepressantsNarcotics
Interventions
DRUG

2% lidocaine with 1:200,000 epinephrine and epidural morphine

Epidurals will be dosed with 2% lidocaine with 1:200,000 epinephrine to T4 level in 5ml increments, epidural morphine 3mg will be given after delivery of neonate. T4 level maintained throughout cesarean delivery with additional epidural doses of 2% lidocaine with 1:200,000 epinephrine for both groups. Post-operative orders of scheduled acetaminophen and ibuprofen, and oxycodone as needed will be written.

DRUG

3% 2-chloroprocaine and epidural morphine

Epidurals will be dosed with 3% 2-chloroprocaine to T4 level in 5ml increments, epidural morphine 3mg will be given after delivery of neonate. T4 level maintained throughout cesarean delivery with additional epidural doses of 2% lidocaine with 1:200,000 epinephrine for both groups. This is the critical component to bridge the latency period between the offset of 3% 2-chloroprocaine and the peak action of epidural morphine.Post-operative orders of scheduled acetaminophen and ibuprofen, and oxycodone as needed will be written.

Trial Locations (1)

77030

The University of Texas Health Science Center at Houston, Houston

All Listed Sponsors
lead

The University of Texas Health Science Center, Houston

OTHER

NCT04369950 - Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine | Biotech Hunter | Biotech Hunter