Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19

Patients will receive 25 microgram per kilogram of body weight tirofiban as bolus IV injection (3 minutes) followed by continuous infusion at a rate of 0,15 microgram/kg//minute for 48 hours.

Patients will receive a loading dose of clopidogrel 300 mg PO, followed by 75mg daily for 30 days

Patients will receive acetylsalicylic acid 250 mg IV before starting tirofiban, and this will be continued at a dose of 75mg daily for 30 days.

Patients will receive concurrent fondaparinux 2.5mg s/c per day for the duration of the in hospital stay