840
Participants
Start Date
January 1, 1989
Primary Completion Date
January 31, 1993
Study Completion Date
December 31, 2000
Usual Protein Diet
The usual protein diet contains 1.30 g/kg/day protein and 16-20 mg/kg/day of Phosphorus
Low Protein Diet
The low protein diet contains 0.575 g/kg/day protein and 5-10 mg/kg/day of Phosphorus
Very Low Protein Diet
The very low protein diet contains 0.28 g/kg/day or protein, mg/kg/day of Phosphorus and a keto acid mixture.
Medications needed to maintain usual blood pressure
The MAP goal for the usual blood pressure group is \<=107 mm Hg for ages 18-60 and \<=113 for ages 61+. Pharmacological and non-pharmacological therapies will be used to achieve the desired blood pressure values. The recommended anti-hypertensive regimen is a angiotensin-converting-enzyme inhibitor with or without a diuretic agent; a calcium-channel blocker or other medications can be added as needed.
Medications needed to maintain low blood pressure
The MAP goal for the low blood pressure group is \<=92 mm Hg for ages 18-60 and \<=98 for ages 61+. Pharmacological and non-pharmacological therapies will be used to achieve the desired blood pressure values. The recommended anti-hypertensive regimen is a angiotensin-converting-enzyme inhibitor with or without a diuretic agent; a calcium-channel blocker or other medications can be added as needed.
The Cleveland Clinic
OTHER
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH