Nebulised Rt-PA for ARDS Due to COVID-19

"Patients in the rt-PA group received the first dose as soon as possible after registration.~Initial dosing regime: 10 mg of rt-PA dissolved in 5 ml of diluent given every 6 hrs (resulting in a total daily dose of 40mg) for a maximum of 66 hrs, in addition to standard of care for COVID-19 acute respiratory distress syndrome (ARDS). Following protocol amendment, dosing duration was increased from 3 days to up to 14 days of rt-PA treatment."

Patients on IMV received 60mg daily over three doses for up to 14 days

NIV patients received 60mg daily over 3 doses for two days, followed by 12 days receiving 40mg daily over two doses.