Stopping ACE-inhibitors in COVID-19

PHASE4CompletedINTERVENTIONAL
Enrollment

216

Participants

Timeline

Start Date

April 20, 2020

Primary Completion Date

February 16, 2021

Study Completion Date

February 24, 2021

Conditions
SARS-CoV-2COVID-19
Interventions
DRUG

ACE inhibitor, angiotensin receptor blocker

In patients randomized to stopping / replacing ACEI or ARB, it may be necessary to switch to another drug without direct effect on the RAS system. In patients, randomized to continuation, it may be needed to stop ACEI or ARB (e.g. hypotension with beginning sepsis) irrespective of the study.

Trial Locations (31)

6020

Medical University Innsbruck, University Hospital of Internal Medicine III, Innsbruck

81377

LMU Klinikum, Medizinische Klinik I, Munich

Unknown

Medical University of Graz, Graz

Landeskrankenhaus Hall, Hall in Tirol

Medical University Innsbruck, Intensive Care and Emergency Medicine Department, Innsbruck

Medical University Innsbruck, University Hospital of Internal Medicine II, Innsbruck

Medical University Innsbruck, University Hospital of Internal Medicine IV, Innsbruck

Medical University Innsbruck, University Hospital of Internal Medicine I, Innsbruck

Medical University Innsbruck, University Hospital of Internal Medicine V, Innsbruck

Klinikum Klagenfurt, Klagenfurt

Bezirkskrankenhaus Kufstein, Kufstein

Klinikum Lienz, Lienz

Bezirkskrankenhaus St. Johann, Sankt Johann in Tirol

Bezirkskrankenhaus Schwaz, Schwaz

Krankenhaus St. Vinzenz Zams, Zams

University Hospital Aachen, Aachen

University Hospital Augsburg, Augsburg

Asklepios Stadtklinik Bad Tölz, Bad Tölz

Klinikum Dachau, Dachau

University Hospital Erlangen, Erlangen

University Hospital Essen, Essen

University of Freiburg, Freiburg im Breisgau

Klinikum Memmingen, Memmingen

LMU Klinikum, Medizinische Klinik III, Munich

LMU Klinikum, Medizinische Klinik II, Munich

LMU Klinikum, Medizinische Klinik IV, Munich

München Klinik Bogenhausen und Schwabing, Munich

Rotkreuzklinikum Munich, Munich

Krankenhaus Mühldorf, Mühldorf

Klinikum Rosenheim, Rosenheim

Krankenhaus Weiden, Weiden

All Listed Sponsors
collaborator

Ludwig-Maximilians - University of Munich

OTHER

collaborator

Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)

OTHER

lead

Medical University Innsbruck

OTHER

NCT04353596 - Stopping ACE-inhibitors in COVID-19 | Biotech Hunter | Biotech Hunter