A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

358

Participants

Timeline

Start Date

December 16, 2020

Primary Completion Date

October 15, 2024

Study Completion Date

June 13, 2029

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Osimertinib

Oral

DRUG

Cisplatin

Cisplatin (75mg/m2) to be administered with pemetrexed on Day 1 of every 3-week cycle for 3 cycles.

DRUG

Carboplatin

Carboplatin (AUC5) to be administered with pemetrexed on Day 1 of every 3-week cycle for 3 cycles

DRUG

Placebo

Oral

DRUG

Pemetrexed

Pemetrexed (500 mg/m2) to be administered with cisplatin or carboplatin on Day 1 of every 3-week cycle for 3 cycles

Trial Locations (158)

110

Research Site, Taipei

112

Research Site, Taipei

235

Research Site, Taipei

1113

Research Site, Sofia

1210

Research Site, Vienna

4500

Research Site, Panagyurishte

5804

Research Site, Pleven

6500

Research Site, Ankara

8036

Research Site, Graz

8401

Research Site, Winterthur

10002

Research Site, Taipei

10032

Research Site, New York

10043

Research Site, Orbassano

10330

Research Site, Bangkok

10400

Research Site, Bangkok

11725

Research Site, Commack

12120

Research Site, Pathum Thani

12351

Research Site, Berlin

13013

Research Site, La Libertad

14050

Research Site, D.F

15036

Research Site, Lima

20089

Research Site, Rozzano

20230

Research Site, Aguascalientes

20900

Research Site, Monza

21100

Research Site, Varese

21431

Research Site, Incheon

22031

Research Site, Fairfax

26121

Research Site, Oldenburg

28040

Research Site, Madrid

28222

Research Site, Majadahonda

29010

Research Site, Málaga

33000

Research Site, Bordeaux

33611

Research Site, Bielefeld

34010

Research Site, Istanbul

34214

Research Site, Istanbul

35128

Research Site, Padua

40002

Research Site, Khon Kaen

40201

Research Site, Taichung

40447

Research Site, Taichung

41404

Research Site, Daegu

42601

Research Site, Seoul

44280

Research Site, Malatya

49100

Research Site, Petah Tikva

49124

Research Site, Georgsmarienhütte

50134

Research Site, Florence

50200

Research Site, Chiang Mai

50612

Research Site, Yangsan

51109

Research Site, Cologne

58128

Research Site, Hwasun-gun

62748

Research Site, Tel Aviv

65000

Research Site, Phisanulok

70000

Research Site, Ho Chi Minh City

70124

Research Site, Bari

73657

Research Site, Tainan City

73730

Research Site, Esslingen a.N.

77030

Research Site, Houston

79106

Research Site, Freiburg im Breisgau

82131

Research Site, Gauting

84902

Research Site, Avignon

90404

Research Site, Santa Monica

91010

Research Site, Duarte

91120

Research Site, Jerusalem

92618

Research Site, Irvine

94143

Research Site, San Francisco

95403

Research Site, Santa Rosa

95847

Research Site, Kfar Saba

97067

Research Site, Würzburg

98104

Research Site, Seattle

100000

Research Site, Hanoi

100142

Research Site, Beijing

100191

Research Site, Beijing

105229

Research Site, Moscow

110029

Research Site, New Delhi

191036

Research Site, Saint Petersburg

197758

Research Site, Saint Petersburg

200030

Research Site, Shanghai

200032

Research Site, Shanghai

200433

Research Site, Shanghai

215006

Research Site, Suzhou

221005

Research Site, Varanasi

225001

Research Site, Yangzhou

226001

Research Site, Nantong

249036

Research Site, Obninsk

310009

Research Site, Hangzhou

310022

Research Site, Hangzhou

330006

Research Site, Nanchang

361004

Research Site, Xiamen

400012

Research Site, Mumbai

400037

Research Site, Chongqing

404000

Research Site, Wanzhou

410008

Research Site, Changsha

410013

Research Site, Changsha

420029

Research Site, Kazan'

510062

Research Site, Guangzhou

510095

Research Site, Guangzhou

510120

Research Site, Guangzhou

510515

Research Site, Guangzhou

603081

Research Site, Nizhny Novgorod

610041

Research Site, Chengdu

614990

Research Site, Perm

637001

Research Site, Namakkal

650118

Research Site, Kunming

660133

Research Site, Krasnoyarsk

700000

Research Site, Ho Chi Minh City

830000

Research Site, Ürümqi

3109601

Research Site, Haifa

5265601

Research Site, Ramat Gan

7500713

Research Site, Santiago

7500921

Research Site, Santiago

7560908

Research Site, Las Condes

17204310

Research Site, Jaú

02215

Research Site, Boston

03756

Research Site, Lebanon

14784-400

Research Site, Barretos

60135-040

Research Site, Fortaleza

90035-000

Research Site, Porto Alegre

90610-000

Research Site, Porto Alegre

52010-075

Research Site, Recife

22271-110

Research Site, Rio de Janeiro

97015-450

Research Site, Santa Maria

15090-000

Research Site, São José do Rio Preto

01327-001

Research Site, São Paulo

04038-034

Research Site, São Paulo

04501-000

Research Site, São Paulo

M5G 2N2

Research Site, Toronto

H4A 3J1

Research Site, Montreal

CN-100730

Research Site, Beijing

Unknown

Research Site, Shandong

CN-325000

Research Site, Wenzhou

06120

Research Site, Halle

673-8558

Research Site, Akashi-shi

113-8431

Research Site, Bunkyō City

260-8677

Research Site, Chiba

734-8551

Research Site, Hiroshima

227-8577

Research Site, Kashiwa

135-8550

Research Site, Kōtoku

606-8507

Research Site, Kyoto

951-8566

Research Site, Niigata

541-8567

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

591-8555

Research Site, Sakaishi

981-0914

Research Site, Sendai

160-0023

Research Site, Shinjuku-ku

411-8777

Research Site, Sunto-gun

241-8515

Research Site, Yokohama

'14080

Research Site, Mexico City

0051

Research Site, Lima

L41

Research Site, Lima

LIMA 34

Research Site, Lima

10-357

Research Site, Olsztyn

02447

Research Site, Seoul

08308

Research Site, Seoul

08035

Research Site, Barcelona

CH-8091

Research Site, Zurich

06010

Research Site, Ankara

06800

Research Site, Ankara

B9 5SS

Research Site, Birmingham

L7 8YA

Research Site, Liverpool

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY