Study of Abrocitinib Compared With Dupilumab in Adults With Moderate to Severe Atopic Dermatitis on Background Topical Therapy

PHASE3CompletedINTERVENTIONAL
Enrollment

727

Participants

Timeline

Start Date

June 11, 2020

Primary Completion Date

July 13, 2021

Study Completion Date

July 13, 2021

Conditions
Atopic Dermatitis
Interventions
DRUG

Abrocitinib 200 mg

Abrocitinib 200 mg administered as two 100 mg tablets to be taken orally once daily for 26 weeks. Placebo injections will be administered every other week for 24 weeks.

COMBINATION_PRODUCT

Dupilumab 300 mg

Dupilumab 300 mg administered as a single subcutaneous injection every other week for 24 weeks (2 injections on day 1). Placebo tablets will be administered daily.

Trial Locations (151)

100

National Taiwan University Hospital, Taipei

1033

Clinexpert Kft., Budapest

1431

DCC Alexandrovska EOOD, Sofia

1463

DCC Fokus-5 - Medical Establishment for Outpatient Care EOOD, Sofia

1606

Military Medical Academy MHAT Sofia, Sofia

2065

Royal North Shore Hospital, St Leonards

2217

St George Dermatology and Skin Cancer Centre, Kogarah

2600

MC Asklepii OOD, Dupnitsa

3002

Sinclair Dermatology, East Melbourne

3050

Melbourne Health Radiology, Pakrville

The Royal Melbourne Hospital, Parkville

3053

Skin Health Institute Inc., Carlton

3124

Emeritus Research, Camberwell

3128

Box Hill Hospital, Box Hill

4032

Debreceni Egyetem Klinikai Központ, Debrecen

6720

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged

7400

Trial Pharma Kft., Kaposvár

9300

MHAT Dobrich AD, Dobrich

11217

Taipei Veterans General Hospital, Taipei

15355

Korea University Ansan Hospital, Ansan-si

19103

Paddington Testing Co, Inc., Philadelphia

20520

Mehiläinen Neo, Turku

Turun yliopistollinen keskussairaala, Turku

21431

The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon

23538

Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck

23561

Taipei Medical University-Shuang Ho Hospital, New Taipei City

27804

Boice-Willis Clinic, PA, Rocky Mount

28046

Hospital Universitario La Paz, Madrid

28150

Carolina Research Center, Inc., Shelby

30093

One Health Research Clinic, Norcross

32801

Clinical Neuroscience Solutions, Inc., Orlando

32819

Accel Research Sites - Pure Skin Dermatology & Aesthetics, Orlando

33100

Terveystalo Tampere, Tampere

33173

Miami Dermatology & Laser Research, LLC, Miami

33406

Integrated Clinical Research, West Palm Beach

33486

Skin Care Research, LLC, Boca Raton

33607

Clinical Research Trials of Florida, Inc., Tampa

33614

Olympian Clinical Research, Tampa

33647

Klinikum Bielefeld Rosenhöhe, Bielefeld

33770

Olympian Clinical Research, Largo

35205

Total Skin & Beauty Dermatology Center, PC, Birmingham

35209

Clinical Research Center Of Alabama, Birmingham

36001

Centro de Especialidades Mollabao (Area Sanitaria de Pontevedra e O Salnes), Pontevedra

36071

Hospital de Montecelo, Pontevedra

37130

International Clinical Research - Tennessee LLC, Murfreesboro

38119

Clinical Neuroscience Solutions, Inc., Memphis

46250

Dawes Fretzin Clinical Research Group, LLC, Indianapolis

46617

The South Bend Clinic Center for Research, South Bend

48059

Hamzavi Dermatology, Fort Gratiot

48067

Regional Medical Imaging, P.C. ( Local X-Ray), Royal Oak

48084

Revival Research Institute, LLC, Troy

48149

University of Muenster, Münster

48455

Fachklinik Bad Bentheim, Bad Bentheim

48507

Onyx Clinical Research, Flint

48532

Linden Road Imaging Center, Flint

55128

Dermatologische Gemeinschaftspraxis Dres. Quist, Mainz

57702

Health Concepts, Rapid City

60118

Dundee Dermatology, West Dundee

60596

IKF Pneumologie GmbH & Co KG, Frankfurt am Main

61469

Chonnam National University Hospital, Gwangju

61761

Sneeze, Wheeze & Itch Associates, LLC, Normal

66215

Epiphany Dermatology of Kansas, LLC, Overland Park

68144

Skin Specialists, PC, Omaha

70526

Avant Research Associates, LLC, Crowley

77004

Center for Clinical Studies, LTD. LLP, Houston

77479

Acclaim Dermatology, PLLC, Sugar Land

78229

Dermatology Clinical Research Center of San Antonio, San Antonio

83103

SKINKLINIK s.r.o, Bratislava

84088

Jordan Valley Dermatology Center, West Jordan

85032

Alliance Dermatology & MOHS Center, PC, Phoenix

89129

Studienzentrum Dr. med. Beate Schwarz, Langenau

89148

Vivida Dermatology, Las Vegas

90056

Wallace Medical Group, Inc, Los Angeles

90404

Clinical Science Institute, Santa Monica

90806

Ark Clinical Research, Long Beach

90808

Beach Allergy and Asthma Specialty Group, A Medical Corporation, Long Beach

91767

Empire Clinical Research, Pomona

92103

MedDerm Associates, San Diego

92122

University of California San Diego Dermatology, San Diego

92123

University Clinical Trials Inc., San Diego

92705

Wolverine Clinical Trials, Llc, Santa Ana

92708

First OC Dermatology, Fountain Valley

94132

Synergy Dermatology, San Francisco

97223

Oregon Medical Research Center, Portland

7500906

Centro Radiologico Plaza Baquedano, Santiago

7580150

Medicien, Las Condes, Santiago

7580206

Centro Medico SkinMed Limitada, Santiago

7640881

Clínica Dermacross S.A., Santiago

7750495

MIRES (M Y F Estudios Clinicos Limitada), Nunoa, Santiago

Vida lntegra, Nunoa, Santiago

8380456

Hospital Clinico Universidad de Chile, Santiago

8420383

Centro Internacional de Estudios Clinicos - CIEC, Santiago

02135

MetroBoston Clinical Partners, LLC, Brighton

08520

Psoriasis Treatment Center of Central New Jersey, East Windsor

T2J7E1

Dermatology Research Institute, Calgary

T6G1C3

Alberta DermaSurgery Centre, Edmonton

T4P-1K4

CARE Clinic Ltd, Red Deer

V3R 6A7

Dr. Chih-ho Hong Medical Inc, Surrey

R3M 3Z4

Wiseman Dermatology Research Inc., Winnipeg

A1A 4Y3

Karma Clinical Trials, Inc., St. John's

M8X 1Y9

Kingsway Clinical Research, Etobicoke

P3A 1W8

Medicor Research Inc, Greater Sudbury

P3C 1X8

Sudbury Skin Clinique, Greater Sudbury

N6H 5L5

DermEffects, London

L3P 1X2

Lynderm Research Inc., Markham

L5H 1G9

DermEdge Research, Mississauga

P1B 3Z7

North Bay Dermatology Centre, North Bay

L6J 7W5

The Centre for Clinical Trials, Oakville

K2C 3N2

Dermatology Ottawa Research Centre, Ottawa

K9J 5K2

SKiN Centre for Dermatology, Peterborough

L4B 1A5

The Centre for Dermatology, Richmond Hill

M3H5Y8

Toronto Research Centre, Toronto

G7H 7Y8

Intermed groupe santé, Chicoutimi

G1V 4x7

Centre de Recherche Dermatologique du Quebec metropolitain, Québec

G1W4R4

Centre de Recherche Saint-Louis, Québec

01069

Klinische Forschung Dresden GmbH, Dresden

07548

SRH Wald-Klinikum Gera GmbH, Gera

04103

SIBAmed GmbH, Leipzig

00168

Fondazione Policlinico Universitario A. Gemelli IRCCS Universita Cattolica del Sacro Cuore, Roma

LV-1003

Health Centre 4 Ltd. Diagnostics Centre, Riga

LLC J.Kisis, Riga

LV-3601

Outpatient Clinic of Ventspils, Ventspils

15-453

NZOZ Specjalistyczny Osrodek Dermatologiczny DERMAL s.c., Bialystok

41-500

DERMAPOLIS Medical Dermatology Center, Chorzów

80-214

Uniwersyteckie Centrum Kliniczne, Gdansk

05-825

MCBK, Grodzisk Mazowiecki

40-568

Care Clinic Centrum Medyczne, Katowice

31-501

Krakowskie Centrum Medyczne Sp. z o.o., Krakow

31-513

Centrum Medyczne Promed, Krakow

90-242

Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna, Lodz

90-265

"Niepubliczny Zaklad Opieki Zdrowotnej DERMED Centrum Medyczne", Lodz

27-400

Dermedic Jacek Zdybski, Ostrowiec Świętokrzyski

61-441

Gabinety Lekarskie Rivermed, Poznan

70-332

"Spolka Cywilna Andrzej Krolicki, Tomasz Kochanowski, ,,Laser Clinic", Szczecin

71-434

Twoja Przychodnia - Szczecinskie Centrum Medyczne, Szczecin

00-874

Medycyna Kliniczna, Warsaw

02-106

MTZ Clinical Research Sp. z o.o., Warsaw

02-661

Carpe Diem Centrum Medycyny Estetycznej, Warsaw

50-220

EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej, Wroclaw

50-566

Cityclinic Przychodnia Lekarsko Psychologiczna Matusiak Spółka Partnerska, Wroclaw

52-416

Centrum Medyczne Oporow, Wroclaw

41-800

Kliniczny Oddzial Chorob Wewnetrznych, Dermatologii i Alergologii, Zabrze

831 01

SUMMIT CLINICAL RESEARCH, s.r.o., Bratislava

841 02

BeneDerma s.r.o., Bratislava

851 01

Derma therapy spol. s.r.o., Bratislava

940 34

Dermatovenerologicka ambulancia, Nové Zámky

089 01

SANARE spol.s.r.o., Svidník

03722

Severance Hospital, Yonsei University Health System, Seoul

06973

Chung-Ang University Hospital, Seoul

08916

Hospital Germans Trias i Pujol, Badalona

08036

Hospital Clinic de Barcelona, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY