A Phase III Clinical Trial of AK105 Injection Combined With Anlotinib Hydrochloride Capsules Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

648

Participants

Timeline

Start Date

August 11, 2020

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Advanced Hepatocellular Carcinoma (HCC)
Interventions
DRUG

AK105 Injection

AK105 200mg intravenously (IV) on day 1 of each 21-day cycle.

DRUG

Anlotinib Hydrochloride Capsules

Anlotinib capsules 10mg given orally in fasting conditions , once daily in 21-day cycle (14 days on treatment from Day 1-14, 7 days off treatment from Day 15-21).

DRUG

Sorafenib Tosylate Tablets

Sorafenib Tosylate Tablets 400mg given orally, twice daily in 21-day cycle.

Trial Locations (81)

13000

Jilin Cancer Hospital, Changchun

67020

Affiliated Hospital of Chengde Medical University, Chengde

100015

Beijing Ditan Hospital.Capital Medical University, Beijing

100069

Beijing YouAn Hospital.Capital Medical University, Beijing

100730

Peking Union Medical College Hospital, Beijing

100853

Chinese Pla General Hospital, Beijing

102218

Beijing Tsinghua Changgung Hospital, Beijing

110006

The Sixth People's Hospital Of Shenyang, Shenyang

110042

Liaoning Cancer Hospital, Shenyang

121012

The First Affiliated Hospital of Jinzhou Medical University, Jinzhou

130021

The First Hospital Affiliated to Jilin Universit, Changchun

130700

Jilin Guowen Hospital, Changchun

150081

Affiliated Tumor Hospital of Harbin Medical University, Harbin

200032

Fudan University Shanghai Cancer Center, Shanghai

Zhongshan Hospital, Fuadn University, Shanghai

201800

The Third Affiliated Hospital of the Second Military Medical University of the Chinese people's Liberation Army, Shanghai

210000

The First Affiliated Hospital of Nanjing Medical University, Nanjing

210003

The Second Hospital of Nanjing, Nanjing

210029

Jiangsu Cancer Hospital, Nanjing

226361

Nantong Tumor Hospital, Nantong

230001

Anhui Provincial Hospital, Hefei

230022

The First Affiliated Hospital of Anhui Medical University, Hefei

230031

Anhui Provincial Cancer Hospital, Hefei

233004

The First Affiliated Hospital of Bengbu Medical College, Bengbu

250012

Qilu Hospital of Shandong University, Jinan

252004

Liaocheng people's Hospital, Liaocheng

262550

Yidu Central Hospital Of Weifang, Weifang

300060

Tianjin Medical University Cancar institute & Hospital, Tianjin

300170

Tianjin Third Central Hospital, Tianjin

300192

Tianjin Second People's Hospital, Tianjin

310015

Shulan (Hangzhou) hospital, Hangzhou

325000

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

325041

Wenzhou People's Hospital, Wenzhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

350005

The First Affiliated Hospital of Fujian Medical University, Fuzhou

350014

Fujian Provincial Cancer Hospital, Fuzhou

First Hospital Of Qinhuangdao, Qinhuangdao

361003

The First Affiliated Hospital of Xiamen University, Xiamen

361004

Zhongshan Hospital Xiamen University, Xiamen

400010

The Second Affiliated Hospital of Chongqing Medical University, Chongqing

404031

Chongqing University Three Gorges Hospital, Chongqing

410008

Xiangya Hospital Central South University, Changsha

410013

Hunan Cancar Hospital, Changsha

The Third Xiangya Hospital of Central South University, Changsha

410021

Hunan Provincial People's Hospital, Changsha

410205

Hunan Cancer Hospital(Department II of Gastroenterology and Urology/Hepatobiliary Surgery), Changsha

430071

Zhongnan Hospital of Wuhan University, Wuhan

430079

Hubei Cancer Hospital, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

453000

Xinxiang central hospital, Xinxiang

471003

The First Affiliated Hospital of Henan University of Science and Technology, Luoyang

472000

Sanmenxia Central Hospital, Sanmenxia

473006

Nanyang First People's Hospita, Nanyang

510080

Guangdong Provincial People's Hospital, Guangzhou

510289

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou

530021

Guangxi Medical University Affiliated Tumor Hospital, Nanning

The First Affiliated Hospital of Guangxi Medical University, Nanning

530031

The Second Nanning People's Hospital, Nanning

550002

Guizhou Provincial People's Hospital, Guiyang

550081

Cancer Hospital of Guizhou Medical University, Guiyang

563099

Affiliated Hospital of Zunyi Medical University, Zunyi

570311

Hainan General Hospital, Haikou

The Second Affiliated Hospital of Hainan Medical Universit, Haikou

610042

Sichuan Cancer Hospital, Chengdu

610081

Affiliated Hospital of Chengdu University, Chengdu

637000

Affiliated Hospital of North Sichuan Medical College, Nanchong

710038

Tangdu Hospital of the Fourth Military Medical University of the People's Liberation Army of China, Xi’an

710061

First Affiliated Hospital of Xi'an Jiaotong University, Xi’an

Shanxi Provincial Cancer Hospital, Xi’an

721000

Baoji Central Hospital, Baoji

723000

Hanzhong Central Hospital, Hanzhong

730000

The first hospital of Lanzhou University, Lanzhou

730030

Lanzhou University Second Hospital, Lanzhou

730099

Gansu Provincial Hospital, Gansu

733000

Gansu Wuwei Tumour Hospital, Wuwei

830054

The First Affiliated Hospital of Xinjiang Medical University, Ürümqi

Unknown

Beijing Luhe Hospital.Capital Medical University, Beijing

The First Affiliated Hospital,Sun Yat-sen University, Guangzhou

050051

The Third Hospital of Hebei Medical University, Shijiazhuang

030013

Shanxi Provinaial Cancer Hospital, Taiyuan

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY