Testing the Addition of Nivolumab to Chemotherapy in Treatment of Soft Tissue Sarcoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

November 4, 2020

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
Skin AngiosarcomaSkin Radiation-Related AngiosarcomaVisceral Angiosarcoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of blood

DRUG

Cabozantinib S-malate

Given PO

PROCEDURE

Computed Tomography

Undergo CT, spiral CT

PROCEDURE

FDG-Positron Emission Tomography

Undergo FDG-PET

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Nivolumab

Given IV

DRUG

Paclitaxel

Given IV

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (171)

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

11042

Northwell Health/Center for Advanced Medicine, Lake Success

14263

Roswell Park Cancer Institute, Buffalo

15146

UPMC Hillman Cancer Center - Monroeville, Monroeville

15215

UPMC-Saint Margaret, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17701

UPMC Susquehanna, Williamsport

17754

Divine Providence Hospital, Williamsport

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

20016

Sibley Memorial Hospital, Washington D.C.

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

23298

VCU Massey Comprehensive Cancer Center, Richmond

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28210

Atrium Health Pineville/LCI-Pineville, Charlotte

29303

North Grove Medical Park, Spartanburg

Spartanburg Medical Center, Spartanburg

29307

Spartanburg Medical Center - Mary Black Campus, Spartanburg

29341

Gibbs Cancer Center-Gaffney, Gaffney

29379

SMC Center for Hematology Oncology Union, Union

29651

Gibbs Cancer Center-Pelham, Greer

30308

Emory University Hospital Midtown, Atlanta

32610

University of Florida Health Science Center - Gainesville, Gainesville

33607

Moffitt Cancer Center-International Plaza, Tampa

33612

Moffitt Cancer Center - McKinley Campus, Tampa

Moffitt Cancer Center, Tampa

37067

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

46845

Parkview Regional Medical Center, Fort Wayne

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

53226

Medical College of Wisconsin, Milwaukee

54017

Cancer Center of Western Wisconsin, New Richmond

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55008

Cambridge Medical Center, Cambridge

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

Minnesota Oncology - Burnsville, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

Fairview Northland Medical Center, Princeton

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60504

Rush-Copley Medical Center, Aurora

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

60612

Rush MD Anderson Cancer Center, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

OSF Saint Anthony's Health Center, Alton

62401

Carle Physician Group-Effingham, Effingham

62864

SSM Health Good Samaritan, Mount Vernon

63011

Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin

63090

Mercy Hospital Washington, Washington

63109

Mercy Infusion Center - Chippewa, St Louis

63110

Washington University School of Medicine, St Louis

63128

Mercy Hospital South, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

Phelps Health Delbert Day Cancer Institute, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

68114

Nebraska Methodist Hospital, Omaha

71103

LSU Health Sciences Center at Shreveport, Shreveport

72903

Mercy Hospital Fort Smith, Fort Smith

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

80045

UCHealth University of Colorado Hospital, Aurora

84106

University of Utah Sugarhouse Health Center, Salt Lake City

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85054

Mayo Clinic Hospital in Arizona, Phoenix

85259

Mayo Clinic in Arizona, Scottsdale

85704

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

91010

City of Hope Comprehensive Cancer Center, Duarte

96701

Hawaii Cancer Care - Westridge, ‘Aiea

Pali Momi Medical Center, ‘Aiea

Queen's Cancer Center - Pearlridge, ‘Aiea

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96706

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96732

Straub Medical Center - Kahului Clinic, Kahului

96734

Castle Medical Center, Kailua

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Island Urology, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Hawaii Diagnostic Radiology Services LLC, Honolulu

Kuakini Medical Center, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

96913

FHP Health Center-Guam, Tamuning

97239

Oregon Health and Science University, Portland

98109

Fred Hutchinson Cancer Center, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

06418

Smilow Cancer Hospital-Derby Care Center, Derby

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06477

Smilow Cancer Hospital-Orange Care Center, Orange

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

Smilow Cancer Hospital Care Center - Waterford, Waterford

32224-9980

Mayo Clinic in Florida, Jacksonville

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

07601

Hackensack University Medical Center, Hackensack

02891

Smilow Cancer Hospital Care Center - Westerly, Westerly

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH