90
Participants
Start Date
November 4, 2020
Primary Completion Date
September 30, 2026
Study Completion Date
September 30, 2026
Biospecimen Collection
Undergo collection of blood
Cabozantinib S-malate
Given PO
Computed Tomography
Undergo CT, spiral CT
FDG-Positron Emission Tomography
Undergo FDG-PET
Magnetic Resonance Imaging
Undergo MRI
Nivolumab
Given IV
Paclitaxel
Given IV
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Memorial Sloan Kettering Cancer Center, New York
Northwell Health/Center for Advanced Medicine, Lake Success
Roswell Park Cancer Institute, Buffalo
UPMC Hillman Cancer Center - Monroeville, Monroeville
UPMC-Saint Margaret, Pittsburgh
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
UPMC Susquehanna, Williamsport
Divine Providence Hospital, Williamsport
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
Sibley Memorial Hospital, Washington D.C.
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
VCU Massey Comprehensive Cancer Center, Richmond
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Atrium Health Pineville/LCI-Pineville, Charlotte
North Grove Medical Park, Spartanburg
Spartanburg Medical Center, Spartanburg
Spartanburg Medical Center - Mary Black Campus, Spartanburg
Gibbs Cancer Center-Gaffney, Gaffney
SMC Center for Hematology Oncology Union, Union
Gibbs Cancer Center-Pelham, Greer
Emory University Hospital Midtown, Atlanta
University of Florida Health Science Center - Gainesville, Gainesville
Moffitt Cancer Center-International Plaza, Tampa
Moffitt Cancer Center - McKinley Campus, Tampa
Moffitt Cancer Center, Tampa
Vanderbilt-Ingram Cancer Center Cool Springs, Franklin
Vanderbilt Breast Center at One Hundred Oaks, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
Ohio State University Comprehensive Cancer Center, Columbus
Parkview Regional Medical Center, Fort Wayne
University of Michigan Comprehensive Cancer Center, Ann Arbor
Mary Greeley Medical Center, Ames
McFarland Clinic - Ames, Ames
McFarland Clinic - Boone, Boone
McFarland Clinic - Jefferson, Jefferson
McFarland Clinic - Marshalltown, Marshalltown
McFarland Clinic - Trinity Cancer Center, Fort Dodge
Medical College of Wisconsin, Milwaukee
Cancer Center of Western Wisconsin, New Richmond
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Medical Center - Minocqua, Minocqua
Marshfield Medical Center-EC Cancer Center, Eau Claire
Marshfield Medical Center-Rice Lake, Rice Lake
Cambridge Medical Center, Cambridge
Lakeview Hospital, Stillwater
Fairview Lakes Medical Center, Wyoming
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Saint John's Hospital - Healtheast, Maplewood
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Minnesota Oncology - Burnsville, Burnsville
Monticello Cancer Center, Monticello
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
Fairview Northland Medical Center, Princeton
Saint Francis Regional Medical Center, Shakopee
Ridgeview Medical Center, Waconia
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
North Memorial Medical Health Center, Robbinsdale
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Health Partners Inc, Minneapolis
Mayo Clinic in Rochester, Rochester
New Ulm Medical Center, New Ulm
Rice Memorial Hospital, Willmar
NorthShore University HealthSystem-Glenbrook Hospital, Glenview
NorthShore University HealthSystem-Highland Park Hospital, Highland Park
Northwestern Medicine Lake Forest Hospital, Lake Forest
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Northwestern Medicine Cancer Center Delnor, Geneva
NorthShore University HealthSystem-Evanston Hospital, Evanston
Rush-Copley Medical Center, Aurora
Northwestern Medicine Cancer Center Warrenville, Warrenville
Rush-Copley Healthcare Center, Yorkville
Northwestern University, Chicago
Rush MD Anderson Cancer Center, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Carle Cancer Center, Urbana
The Carle Foundation Hospital, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
OSF Saint Anthony's Health Center, Alton
Carle Physician Group-Effingham, Effingham
SSM Health Good Samaritan, Mount Vernon
Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin
Mercy Hospital Washington, Washington
Mercy Infusion Center - Chippewa, St Louis
Washington University School of Medicine, St Louis
Mercy Hospital South, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Heartland Regional Medical Center, Saint Joseph
Freeman Health System, Joplin
Mercy Hospital Joplin, Joplin
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
Phelps Health Delbert Day Cancer Institute, Rolla
Central Care Cancer Center - Bolivar, Bolivar
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Central Care Cancer Center - Great Bend, Great Bend
Central Care Cancer Center - Garden City, Garden City
Nebraska Methodist Hospital, Omaha
LSU Health Sciences Center at Shreveport, Shreveport
Mercy Hospital Fort Smith, Fort Smith
University of Oklahoma Health Sciences Center, Oklahoma City
Mercy Hospital Oklahoma City, Oklahoma City
Cancer Centers of Southwest Oklahoma Research, Lawton
UCHealth University of Colorado Hospital, Aurora
University of Utah Sugarhouse Health Center, Salt Lake City
Huntsman Cancer Institute/University of Utah, Salt Lake City
Mayo Clinic Hospital in Arizona, Phoenix
Mayo Clinic in Arizona, Scottsdale
University of Arizona Cancer Center-Orange Grove Campus, Tucson
Banner University Medical Center - Tucson, Tucson
University of Arizona Cancer Center-North Campus, Tucson
City of Hope Comprehensive Cancer Center, Duarte
Hawaii Cancer Care - Westridge, ‘Aiea
Pali Momi Medical Center, ‘Aiea
Queen's Cancer Center - Pearlridge, ‘Aiea
The Cancer Center of Hawaii-Pali Momi, ‘Aiea
The Queen's Medical Center - West Oahu, ‘Ewa Beach
Straub Medical Center - Kahului Clinic, Kahului
Castle Medical Center, Kailua
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu
Island Urology, Honolulu
Queen's Cancer Cenrer - POB I, Honolulu
Queen's Medical Center, Honolulu
Straub Clinic and Hospital, Honolulu
University of Hawaii Cancer Center, Honolulu
Hawaii Cancer Care Inc-Liliha, Honolulu
Hawaii Diagnostic Radiology Services LLC, Honolulu
Kuakini Medical Center, Honolulu
Queen's Cancer Center - Kuakini, Honolulu
The Cancer Center of Hawaii-Liliha, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
FHP Health Center-Guam, Tamuning
Oregon Health and Science University, Portland
Fred Hutchinson Cancer Center, Seattle
University of Washington Medical Center - Montlake, Seattle
Smilow Cancer Hospital-Derby Care Center, Derby
Smilow Cancer Hospital Care Center-Fairfield, Fairfield
Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury
Smilow Cancer Hospital Care Center at Greenwich, Greenwich
Smilow Cancer Hospital Care Center - Guilford, Guilford
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
Yale University, New Haven
Yale-New Haven Hospital North Haven Medical Center, North Haven
Smilow Cancer Hospital-Orange Care Center, Orange
Smilow Cancer Hospital-Torrington Care Center, Torrington
Smilow Cancer Hospital Care Center-Trumbull, Trumbull
Smilow Cancer Hospital-Waterbury Care Center, Waterbury
Smilow Cancer Hospital Care Center - Waterford, Waterford
Mayo Clinic in Florida, Jacksonville
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
Hackensack University Medical Center, Hackensack
Smilow Cancer Hospital Care Center - Westerly, Westerly
National Cancer Institute (NCI)
NIH