The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

483

Participants

Timeline

Start Date

December 12, 2020

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2026

Conditions
Head and Neck Cancer
Interventions
DRUG

Buparlisib & Paclitaxel

Investigation drug plus paclitaxel

Trial Locations (162)

500

Changhua Christian Hospital, Changhua

833

Chang Gung Memorial Hospital-KaohSiung, Kaohsiung City

1090

Universitair Ziekenhuis Brussel, Jette

1122

Orszagos Onkologiai Intezet, Budapest

1125

Fundacion Cenit para la Investigacion en Neurociencias, Buenos Aires

1340

Clinique Saint-Pierre dOttignies CSPO, Ottignies

2841

Korea University Anam Hospital, Seoul

4000

Clinique CHC MontLégia, Liège

4102

Princess Alexandra Hospital, Brisbane

5505

Asan Medical Center, Seoul

6591

The Catholic University of Korea Seoul ST. Mary's Hospital, Seoul

7100

Tolna Megyei Balassa Janos Korhaz, Szekszárd

7624

University of Pecs Department of Oncotherapy, Pécs

8308

Korea University Guro Hospital, Seoul

9000

Universitair Ziekenhuis Gent UZ Gent, Ghent

10016

NYU Langone, New York

10060

Istituto di Candiolo IRCCS, Candiolo

10461

Montefiore Medical Center, The Bronx

11217

Taipei Veterans General Hospital, Taipei

11794

Stony Brook University Medical Center, Stony Brook

12100

A.O. S. Croce e Carle, Cuneo

13005

Hopital de la Timone, Marseille

13620

Seoul National University Bundang Hospital, Seongnam-si

14000

Centre Franois Baclesse, Caen

14004

Hospital Reina Sofia, Córdoba

15009

Fundacion Oncologico de Galicia Jos Antonio Quiroga y Pieyro, A Coruña

15232

UPMC Hillman Cancer Center, Pittsburgh

15706

Hospital Universitario Santiago de Compostela, Santiago de Compostela

16499

Ajou University Hospital, Suwon

17489

Universitatsmedizin Greifswald - KoR, Greifswald

19111

Fox Chase Cancer Center, Philadelphia

20089

IRCCS Istituto Clinico Humanitas, Rozzano

20133

Istituto Nazionale dei Tumori, Milan

20142

Azienda Ospedaliera San Paolo Polo Universitario, Milan

20246

Universitatsklinikum Hamburg Eppendorf, Hamburg

21565

Gachon University Gil Medical Center, Incheon

22045

Marienkrankenhaus Hamburg, Hamburg

23007

Complejo Hospitalario de Jaen, Jaén

23100

ASST Valtellina e Alto Lario - UOC Oncologia Medica Ospedale di Sondrio, Sondrio

25123

ASST Spedali Civili Brescia, Brescia

27003

Hospital Universitario Lucus Augusti, Lugo

27100

IRCCS Maugeri Pavia, Pavia

27710

Duke University Medical Center, Durham

28027

Clinica Universidad de Navarra, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28100

"A.O.U. Maggiore della Carita- S.C.D.U Oncologiac", Novara

28220

Hospital Puerta de Hierro- Majadahonda, Majadahonda

28911

Hospital Universitario Severo Ochoa, Leganés

29010

Hospital Regional de Malaga, Málaga

29425

Hollings Cancer Center, Charleston

30120

Hospital Clinico Universitario Virgen de la Arrixaca, Madrid

30322

Emory University, Atlanta

30625

Hannover Medical School, Hanover

31008

Hospital de Navarra, Pamplona

33075

Centre hospitalier Universitaire de Bordeaux, Bordeaux

33100

Azienda Sanitaria Universitaria Integrata di Udine, Udine

33342

Chang Gung Memorial Hospital-LinKou, Taoyuan District

33612

Moffitt Cancer Center, Tampa

34298

Institut regional du Cancer de Montpellier, Montpellier

35392

HNO-Klinik des Universitats-Klinikums Giessen, Giessen

35760

CHP Saint-Grégoire, Saint-Grégoire

37126

Azienda Ospedaliera Universitaria Integrata Verona, Verona

38138

West Cancer Center, Germantown

39008

Hospital Universitario Marques de Valdecilla, Santander

40138

Azienda Ospedaliera Universitaria S.Orsola-Malpighi, Bologna

40202

Norton Cancer Institute, Louisville

40536

University of Kentucky, Lexington

40705

Taichung Veterans General Hospital, Taichung

41014

Valme Hospital Medical Oncology Department, Seville

43126

Azienda Ospedaliero Universitaria di Parma, Parma

44277

LHopital prive du Confluent Nantes, Nantes

45147

University Hospital Essen, Essen

45219

University of Cincinnati Cancer Center, Cincinnati

46009

Instituto Valenciano de Oncologia, Valencia

46010

Hospital Clinico Universitario Valencia - INCLIVA, Valencia

48109

University of Michigan, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

48202

Henry Ford Health System, Detroit

49124

Franziskus Hospital, Georgsmarienhütte

49267

Kosin University Gospel Hospital, Busan

50009

Hospital Universitario Miguel Servet, Zaragoza

50134

Azienda Ospedaliero Universitaria Careggi - Firenze, Florence

52074

Uniklinik RWTH Aachen, Aachen

53100

Azienda Ospedaliera Universitaria Senese Policlinico Le Scotte, Siena

53127

Universitaetsklinikum Bonn, Bonn

54500

Institut de cancerologie de Lorraine, Vandœuvre-lès-Nancy

55131

UNIVERSITÄTSMEDIZIN Mainz III. Klinik/Poliklinik, Mainz

60611

Northwestern University, Chicago

63130

Washington University School of Medicine, St Louis

69008

Centre Leon Berard, Lyon

73039

AO Card. G. Panico, Tricase

73657

Chi Mei Medical Center Liouying, Tainan City

75010

Hôpital St-Louis, Paris

75013

Hopital La Pitie Salpetriere, Paris

75701

Hope Cancer Center, UT Health East Texas, Tyler

75970

Hopital Tenon, Paris

80131

INT IRCCS Fondazione G.Pascale, Napoli

84131

AOU San Giovanni di Dio e Ruggi D'Aragona, Università degli Studi di Salerno, Salerno

90127

"Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone U.O.C. Oncologia Medica", Palermo

91010

City of Hope, Duarte

92200

Clinique Hartmann, Neuilly-sur-Seine

100176

Beijing Tongren Hospital, Beijing

230031

Anhui Provincial Cancer Hospital, Hefei

233004

The First Affiliated Hospital of Bengbu Medical College, Bengbu

250000

Shandong Provincial Tumor Hospital, Jinan

300202

Tianjin Cancer Hospital, Tianjin

310022

Zhejiang Cancer Hospital, Hangzhou

310115

Shanghai Dongfang Hospital, Shanghai

400000

Affiliated Cancer Hospital of Chongqing University, Chongqing

400042

The First Affiliated Hospital of CQMU, Chongqing

410000

Hunan Cancer Hospital, Changsha

Xiangya Hospital Central South University, Changsha

450000

Henan Cancer Hospital, Zhengzhou

510000

Sun Yat-sen University Cancer Center, Guangzhou

510095

Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou

519000

The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai

530021

Cancer Hospital affiliated to Guangxi Medical University, Naning

610042

Sichuan Cancer Hospital, Chengdu

650000

Yunnan Cancer Hospital, Kunming

704017

National Cheng Kung University Hospital, Tainan City

06511

Yale University, Yale Cancer Center, New Haven

B2700CPM

Centro de Investigacion Pergamino SA - Clinica Pergamino S.A., Buenos Aires

C1012AAR

Instituto de Investigaciones Metabólicas (IDIM) // Instituto de Investigaciones Metabólicas S.A., Ciudad Autonoma de Buenos Aire

X5002HWE

IONC SRL- Instituto Oncológico de Córdoba, Córdoba

F5300COE

Fundacion CORI para la Investigacion y Prevencion del Cáncer, La Rioja

T4000GTB

Centro para la Atencion Integral del Paciente Oncologico - CAIPO, San Miguel de Tucumán

H2X 0C2

CHUM, Montreal

R3E 0V9

CancerCare Manitoba, Winnipeg

04103

Universitatsklinikum Leipzig, Leipzig

Unknown

Queen Mary Hospital, Hong Kong

IRCCS - Istituto Scientifico Romagnolo per la Cura e lo Studio dei Tumori, Cesena

Hospital General Universitario Gregorio Maran, Madrid

673-8558

Hyogo Cancer Center, Akashi-shi

104-0045

National Cancer Center Hospital, Chūōku

812-8582

Kyushu University Hospital, Fukuoka

350-1298

Saitama Medical University International Medical Center, Hidaka

761-0793

Kagawa University Hospital, Kita-gun

650-0017

Kobe University Hospital, Kobe

135-8550

The Cancer Institute Hospital of JFCR, Kōtoku

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

464-8681

Aichi Cancer Center, Nagoya

589-8511

Kindai University Hospital, Osaka Sayama-shi

060-8648

Hokkaido University Hospital, Sapporo

980-8574

National University Corporation Tohoku University, Tohoku University Hospital, Sendai

142-8666

Showa University Hospital, Shinagawa-Ku

411-8777

Shizuoka Cancer Center, Shizuoka

44-102

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie, Gliwice

02-781

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie, Warsaw

08916

Institut Catala d Oncologia Badalona, Badalona

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

Vall dHebron Institute of Oncology (VHIO), Barcelona

08036

Hospital Clinic Barcelona, Barcelona

09006

Hospital Universitario de Burgos, Burgos

08908

Hospital Duran i Reynals - Institut Catala dOncologia ICO, L'Hospitalet de Llobregat

EH4 2XU

Edinburgh Cancer Center, Edinburgh

G12 0YN

Beatson Oncology Centre, Glasgow

NW1 2BU

University College London Hospitals, London

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

SM2 5PT

The Royal Marsden NHS Foundation Trust - Sutton, Sutton

All Listed Sponsors
lead

Adlai Nortye Biopharma Co., Ltd.

INDUSTRY