A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor Treatment

PHASE3CompletedINTERVENTIONAL
Enrollment

522

Participants

Timeline

Start Date

July 28, 2020

Primary Completion Date

January 3, 2023

Study Completion Date

March 24, 2025

Conditions
Carcinoma, Renal Cell
Interventions
DRUG

Atezolizumab

Atezolizumab 1200 mg will be administered at a fixed dose on Day 1 of each 21-day cycle by IV infusion every 3 weeks.

DRUG

Cabozantinib

Cabozantinib 60 mg (three 20-mg tablets) administered orally once daily.

Trial Locations (125)

2730

Herlev Hospital, Herlev

2800

Orange Hospital, Orange

3550

Bendigo Cancer Centre, Bendigo

4101

Icon Cancer Foundation, South Brisbane

10003

Hospital San Pedro De Alcantara, Cáceres

10029

Mount Sinai Medical Center, New York

10060

Fondazione del Piemonte per l?Oncologia (IRCCS), Candiolo (TO)

10461

Montefiore Medical Center, The Bronx

12208

New York Oncology Hematology,P.C.-Albany, Albany

12464

Attikon University General Hospital, Athens

13210

SUNY Upstate Medical University, Syracuse

13496

CHA Bundang Medical Center, Gyeonggi-do

13620

Seoul National University Bundang Hospital, Gyeonggi-do

14004

Hospital Universitario Reina Sofia, Córdoba

14076

Centre Francois Baclesse, Caen

19111

Fox Chase Cancer Center, Philadelphia

20089

Istituto Clinico Humanitas, Rozzano

20133

Irccs Istituto Nazionale Dei Tumori (Int), Milan

20155

Virginia Cancer Specialists - Gainsville, Gainesville

20246

Uniklinik-Eppendorf, Hamburg

25030

CHU Besançon - Hôpital Jean Minjoz, Besançon

25123

Asst Degli Spedali Civili Di Brescia, Brescia

27003

Hospital Lucus Augusti, Lugo

27100

Fondazione Salvatore Maugeri, Pavia

27710

Duke University Medical Center, Durham

28007

Hospital General Universitario Gregorio Marañon, Madrid

28034

Hospital Ramon y Cajal, Madrid

28040

Hospital Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

29010

Hospital Clinico Universitario Virgen de la Victoria, Málaga

30120

Hospital Universitario Virgen de Arrixaca, Murcia

30625

Med. Hochschule Hannover, Hämatologie, Hämostaseologie, Onkologie u. Stammzelltransplantation, Hanover

31008

Hospital de Navarra, Navarra

32503

Woodlands Medical Specialists, P.A., Pensacola

33011

Hospital Univ. Central de Asturias, Oviedo

33075

CHU de Bordeaux - Groupe Hospitalier Saint-André - Hopital Saint-Andre, Bordeaux

33612

Moffitt Cancer Center, Tampa

35015

Chungnam National University Hospital, Daejeon

36213

Hospital Alvaro Cunqueiro, Vigo

37134

A.O.U di Verona Policlinico G.B. Rossi, Verona

39008

Hospital Universitario Marques de Valdecilla, Santander

40138

Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, Bologna

41110

University Hospital of Larissa, Larissa

44195

Cleveland Clinic, Cleveland

46026

Hospital Universitario la Fe, Valencia

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola

48149

Universitaetsklinikum Muenster, Münster

50612

Pusan National University Yangsan Hospital, Gyeongsangnam-do

55404

Minnesota Oncology Hematology, Minneapolis

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59000

Centre Oscar Lambret, Lille

60590

Klinikum der Johann Wolfgang Goethe-Universitaet, Frankfurt

62100

Ospedale Di Macerata, Macerata

67200

ICANS, Strasbourg

70124

A.O. Universitaria Ospedale Consorziale Policlinico Di Bari, Bari

72076

Universitätsklinikum Tübingen, Tübingen

75908

Hopital Europeen Georges Pompidou, Paris

78731

Texas Oncology - Central South, Austin

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

80045

University of Colorado, Aurora

80120

Rocky Mountain Cancer Center - Denver, Littleton

80131

Istituto Tumori Napoli, Napoli

81675

Klinikum rechts der Isar der TU München, München

84108

University Of Utah, Salt Lake City

89081

Universitätsklinikum Ulm, Ulm

89169

Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley, Las Vegas

90095

UCLA, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

92093

UC San Diego Health System, La Jolla

94800

Institut Gustave Roussy, Villejuif

111123

"SBIH Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM", Moskva

115478

"FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow

121205

"Branch of the company Hadassah Medical LTD", Innovatsionnogo Tsentra Skolkovo

150054

Regional Clinical Oncology Hospital, Yaroslavl

188663

St-Petersburg Regional Oncology Dispensary, Kuzmolovo

195271

Private Healthcare Institution Clinical Hospital RZhD Medicine, Saint Petersburg

199034

AV Medical Ltd., Saint Petersburg

630099

Medical Center Avicenna, Novosibirsk

85724-5030

University of Arizona, Tucson

02215

Dana-Farber Cancer Institute, Boston

07748

Memorial Sloan Kettering - Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

C1125ABD

Fundación CENIT para la Investigación en Neurociencias, Buenos Aires

C1426ANZ

Inst. Alexander Fleming, Buenos Aires

C1280AEB

Hospital Britanico, Ciudad Autonoma Bs As

C1019ABS

Centro Medico Austral OMI, Ciudad Autonoma Buenos Aires

L8N 4A6

St. Joseph's Healthcare Hamilton, Hamilton

M5G 1Z5

Princess Margaret Cancer Center, Toronto

09130

Zeisigwaldkliniken Bethanien, Chemnitz

06120

Krankenhaus Martha-Maria Halle-Dölau, Klinik für Urologie, Halle

115 28

Alexandras General Hospital of Athens, Athens

151 25

Athens Medical Center, Athens

570 01

Diavalkaniko Hospital, Thessaloniki

00168

"Policlinico Universitario Agostino Gemelli", Rome

05100

Azienda Ospedaliera S. Maria - Terni, Terni

060-8648

Hokkaido University Hospital, Hokkaido

305-8576

University of Tsukuba Hospital, Ibaraki

236-0004

Yokohama City University Hospital, Kanagawa

700-8558

Okayama University Hospital, Okayama

545-8586

Osaka Metropolitan University Hospital, Osaka

770-8503

Tokushima University Hospital, Tokushima

160-8582

Keio University Hospital, Tokyo

162-8666

Tokyo Women's Medical University Hospital, Tokyo

90-338

Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna, ?ód?

85-796

Centrum Onkologii im. Prof. Franciszka ?ukaszczyka, Bydgoszcz

41-902

SP ZOZ Wojewódzki Szpital Specjalistyczny nr 4, Bytom

05-400

Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii, Otwock

60-569

Szpital Kliniczny im. Heliodora ?wi?cickiego UM w Poznaniu, Późna

04-073

Szpital Grochowski im. dr med. Rafa?a Masztaka Sp. z o.o., Warsaw

04-141

Wojskowy Instytut Medyczny, Warsaw

53-413

Dolno?l?skie Centrum Onkologii, Pulmonologii i Hematologii, Wroc?aw

006351

Samsung Medical Center, Seoul

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

07014

Hospital Universitario Son Espases, Palma de Mallorca

08208

Corporacio Sanitaria Parc Tauli, Sabadell

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

09006

Hospital Universitario de Burgos, Burgos

BB2 3HH

Royal Blackburn Hospital, Blackburn

EC1A 7BE

Barts & London School of Med, London

SW3 6JJ

Royal Marsden Hospital, London

M2O 4BX

Christie Hospital Nhs Trust, Manchester

Sponsors
All Listed Sponsors
collaborator

Exelixis

INDUSTRY

collaborator

Chugai Pharmaceutical

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY