479
Participants
Start Date
April 2, 2020
Primary Completion Date
June 19, 2020
Study Completion Date
July 23, 2020
Hydroxychloroquine
"Hydroxychloroquine is available in 200 mg oral tablets of hydroxychloroquine sulfate.~For this COVID-19 trial, we will use an oral or enteral dose of hydroxychloroquine 400 mg twice daily on the day of enrollment, then 200 mg twice daily for the next 4 days for a 5 day total course."
Placebo
Participants randomized to the control group will receive a dose of placebo enterally twice daily for 5 days (a total of 10 doses). The placebo pills will be as similar as possible to the hydroxychloroquine pills to ensure blinding.
Montefiore Medical Center-Weiler, The Bronx
Montefiore Medical Center-Moses, The Bronx
UPMC Presbyterian/Mercy/Shadyside, Pittsburgh
Penn State Hershey Medical Center, Hershey
Temple University Hospital, Philadelphia
VCU Medical Center, Richmond
Wake Forest Baptist Medical Center, Winston-Salem
Medical University of South Carolina, Charleston
University of Florida, Gainesville
Vanderbilt University Medical Center, Nashville
University of Mississippi Medical Center, Jackson
University of Kentucky, Lexington
Ohio State University Wexner Medical Center, Columbus
Cleveland Clinic Foundation, Cleveland
University of Cincinnati Medical Center, Cincinnati
Henry Ford Medical Center, Detroit
University of Michigan Medical Center, Ann Arbor
University Medical Center, New Orleans
University of Texas Health Science Center, Houston
Medical Center of Aurora, Aurora
University of Colorado Hospital, Aurora
Denver Health Medical Center, Denver
St. Joseph Hospital, Denver
Intermountain Medical Center, Murray
University of Utah Hospital, Salt Lake City
University of Arizona, Tucson
Ronald Reagan UCLA Medical Center, Los Angeles
UCSF Fresno, Fresno
UCSF Medical Center, San Francisco
Stanford University, Stanford
UC Davis Medical Center, Sacramento
Oregon Health and Science University, Portland
Harborview Medical Center, Seattle
Swedish Hospital First Hill, Seattle
Maine Medical Center, Portland
Massachusetts General Hospital, Boston
Beth Israel Deaconess Medical Center, Boston
Brigham and Women's Hospital, Boston
Baystate Medical Center, Springfield
St. Vincent's Hospital, Worcester
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Massachusetts General Hospital
OTHER