A Randomized, Multicenter, Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

August 19, 2020

Primary Completion Date

December 28, 2025

Study Completion Date

December 28, 2028

Conditions
DLBCLDiffuse Large B Cell Lymphoma
Interventions
DRUG

R-pola-mini-CHP

"* Rituximab 375 mg/m2 iv, day 1, cycle 1. 1400 mg s c OR 375 mg/m2 iv cycles 2-6~* Cyclophosphamide 400 mg/m2 iv, day 1, cycles 1-6~* Doxorubicin 25 mg/m2 iv , day 1, cycles 1-6~* Prednisone, 40 mg/m2 po, days 1-5, cycles 1-6 - round up to nearest 25 mg~* Polatuzumab vedotin 1.8 mg/kg iv day 1 cycles 1-6"

DRUG

R-mini-CHOP

"* Rituximab 375 mg/m2 i.v., day 1, cycle 1. 1400 mg s c OR 375 mg/m2 i. v. cycles 2-6~* Cyclophosphamide 400 mg/m2 i.v., day 1, cycles 1-6~* Doxorubicin 25 mg/m2 i.v., day 1, cycles 1-6~* Vincristine 1 mg i.v. (total dose), day 1, cycles 1-6~* Prednisone, 40 mg/m2 p.o, days 1-5, , cycles 1-6"

Trial Locations (69)

Unknown

NOT_YET_RECRUITING

Border Medical Oncology Research Unit, Albury

RECRUITING

Royal Prince Alfred Hospital, Camperdown

NOT_YET_RECRUITING

Coffs Harbour, Coffs Harbour

RECRUITING

Concord Repatriation General Hospital, Concord

NOT_YET_RECRUITING

Tweed Valley Hospital, Cudgen

NOT_YET_RECRUITING

The Canberra Hospital, Garran

NOT_YET_RECRUITING

Royal Hobart Hospital, Hobart

RECRUITING

Liverpool, Liverpool

NOT_YET_RECRUITING

Bendigo, Melbourne

NOT_YET_RECRUITING

Northern Health, Melbourne

RECRUITING

St Vincent's Hospital Melbourne, Melbourne

NOT_YET_RECRUITING

Western Health, Melbourne

NOT_YET_RECRUITING

Fiona Stanley Hospital, Murdoch

NOT_YET_RECRUITING

Orange Health, Orange

NOT_YET_RECRUITING

Royal Perth Hospital, Perth

NOT_YET_RECRUITING

Port Macquarie, Port Macquarie

RECRUITING

Prince of Wales Hospital, Randwick

NOT_YET_RECRUITING

Royal North Shore Hospital, St Leonards

RECRUITING

Sunshine Coast University Hospital, Sunshine Coast

NOT_YET_RECRUITING

Calvary Mater Newcastle, Waratah

RECRUITING

Westmead, Westmead

RECRUITING

Department og Hematology, Aalborg University Hospital, Aalborg

RECRUITING

Department of Hematology, Aarhus University Hospital, Aarhus

RECRUITING

Clinic of Hematology L-4241, Rigshospitalet, Copenhagen

RECRUITING

Sydvestjysk Sygehus, Esbjerg

RECRUITING

Regionshospitalet Holstebro, Holstebro

RECRUITING

Department of Hematology X, Odense University Hospital, Odense

RECRUITING

Department of Hematology, Zeeland University Hospital Roskilde, Roskilde

RECRUITING

Vejle Sygehus, Vejle

RECRUITING

Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki

RECRUITING

Kuopio University Hospital, Kuopio

RECRUITING

Oulu University Hospital, Oulu

RECRUITING

Tampere University Hospital, Tampere

RECRUITING

Turku University Hospital, Turku

RECRUITING

Centro di riferimento oncologico di Aviano, Aviano

RECRUITING

"Istituto Tumori Giovanni Paolo II I.R.C.C.S Bari", Bari

NOT_YET_RECRUITING

The G.O.M. Bianchi-Melacrino-Morelli in Reggio Calabria, Calabria

RECRUITING

Ospedale San Gerardo di Monza, Monza

RECRUITING

Azienda Ospedaliera Univeristaria Federico II di Napoli, Napoli

RECRUITING

"Istituto Nazionale Tumori Fondazione Pascale Napoli", Napoli

RECRUITING

Azienda Ospedaliera San Camillo Forlanini di Roma, Roma

RECRUITING

IRCCS San Raffaele Scientific Institute, Segrate

RECRUITING

Azienda Sanitaria Universitaria Integrata di Trieste, Trieste

RECRUITING

AOU San Luigi Gonzaga - Orbassano University of Turin, Turin

RECRUITING

Azienda Sanitaria Universitaria Integrata di Udine, Udine

RECRUITING

Azienda Ospedaliera Universitaria Integrata Verona, Verona

NOT_YET_RECRUITING

Auckland City Hospital, Grafton

NOT_YET_RECRUITING

Wellington Blood and Cancer Centre, Wellington

RECRUITING

Haukeland Universitetshospital, Bergen

RECRUITING

Kalnes Hospital (Østfold), Grålum

RECRUITING

Sykehuset Innlandet, Innlandet

RECRUITING

Akershus University Hospital, Oslo

RECRUITING

Avd. for Kreftbehandling, Oslo universitetssykehus, Oslo

RECRUITING

Avdeling for Blod- og Kreftsykdommer, Stavanger Universitetssykehus, Stavanger

RECRUITING

Kreftklinikken, St Olavs Hospital, Trondheim

RECRUITING

Sykehuset i Vestfold, Tønsberg

RECRUITING

Medicinkliniken, Södra Älvsborg Sjukhus, Borås

RECRUITING

Department of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg

RECRUITING

Department of Medicine, Halmstad Country Hospital, Halmstad

RECRUITING

Department of Internal Medicine, Kalmar County Hospital, Kalmar

RECRUITING

Hematologiska Kliniken, Universitetssjukhuset, Linköping

RECRUITING

Department of Oncology, Skåne University Hospital, Lund

RECRUITING

Department of Oncology, Örebro University Hospital, Örebro

RECRUITING

Department of Medicine, Sunderbyn Hospital, Södra Sunderbyn

RECRUITING

Center of Hematology, Karolinska University Hospital, Stockholm

RECRUITING

Uddevalla Sjukhus, Uddevalla

RECRUITING

Cancercentrum, Norrlands universitetsjukhus, Umeå

RECRUITING

Department of Oncology, Uppsala Academic Hospital, Uppsala

RECRUITING

Varberg Hospital, Varberg

All Listed Sponsors
collaborator

Roche Pharma AG

INDUSTRY

lead

Nordic Lymphoma Group

NETWORK