NCT04330690 - Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial | Biotech Hunter

Enrollment

2,900

Participants

Timeline

Start Date

March 18, 2020

Primary Completion Date

March 10, 2024

Study Completion Date

May 18, 2024

Conditions

COVID-19

Interventions

DRUG

Artesunate

2.4 mg/kg at 0 hours, 12 hours, 24 hours, and then daily for a total of 7 days plus standard of care

DRUG

Imatinib

400 mg enterally daily for 14 days plus standard of care

DRUG

Infliximab

5 mg/kg IV given one time, over 2 hours plus standard of care

DRUG

Dexamethasone

6 mg IV/oral for a further five days, followed by a five day taper of 4 mg x 2 days and 2 mg x 3 days, for a total 20 day steroid course. If randomized to standard of care, discontinue the corticosteroid on day 10

DRUG

LSALT Peptide

5 mg , 2 hour IV infusion once daily for up to 14 consecutive days

Trial Locations (53)

T1Y 6J4

Peter Lougheed Centre, Calgary

T2N 2T9

Foothills Medical Centre, Calgary

T2V 1P9

Rockyview General Hospital, Calgary

T3M 1M4

South Health Campus, Calgary

T5K0L4

Royal Alexandra Hospital, Edmonton

T5R 4H5

Misericordia Community Hospital, Edmonton

T6G 2B7

University of Alberta Hopsital, Edmonton

T6L 5X8

Grey Nuns Community Hospital, Edmonton

V2C2T1

Interior Health Royal Inland Hospital, Kamloops

V7L 2L7

Lions Gate Hospital, North Vancouver

V6X 1A2

Richmond Hospital, Richmond

V5Z1M9

Vancouver General Hospital, Vancouver Coastal Health, Univeristy of British Columbia, Vancouver

V6Z 1Y6

St Paul's Hospital, Vancouver

V8R 1J8

Island Health - Royal Jubilee Hospital, Victoria

V8Z 6R5

Island Health - Victoria General Hospital, Victoria

V9S 2B7

Island Health - Nanaimo Regional General Hospital, Victoria

R2H 2A6

St. Boniface Hospital, Winnipeg

R3A 1R9

Health Sciences Centre, Winnipeg

R3J 3M7

Grace General Hospital, Winnipeg

A1B 3V6

Eastern Regional Health Authority, St. John's

B3S 0H6

Nova Scotia Health Authority, Halifax

L4M 6M2

Royal Victoria Regional Health Centre, Barrie

L6R 3J7

William Osler Health System - Brampton Civic Hospital, Brampton

M9V 1R8

William Osler Health System - Etobicoke General Hospital, Etobicoke

L8N 4A6

St. Joseph's Healthcare Hamilton, Hamilton

N6A 4V2

St.Joseph's Health Care, London

N6A 5A5

University Hospital, London

N6A 5W9

Victoria Hospital, London

L3P 7P3

Markham Stouffville Hospital, Markham

L5B 1B8

Trillium Health Partners -Mississauga Site, Mississauga

L5M 2N1

Trillium Health Partners-Credit Valley Hospital, Mississauga

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

K1K 0T2

Hôpital Montfort, Ottawa

K1Y 4E9

The Ottawa Hospital - Civic Campus, Ottawa

K2H 8P4

Queensway Carleton Hospital, Ottawa

M1E4B9

Scarborough Health Network - Centenary Hospital, Scarborough Village

M1P2V5

Scarborough Health Network - General Hospital, Scarborough Village

M1W3W3

Scarborough Health Network - Birchmount Hospital, Scarborough Village

L2S 0A9

Niagara Health, St. Catharines

P7B 6V4

Thunder Bay Regional Health Sciences Centre, Thunder Bay

M2K 1E1

North York General Hospital, Toronto

M3M 0B2

Humber River Hospital, Toronto

M4C 3E7

Michael Garron Hospital, Toronto

M4N3M5

Sunnybrook Health Sciences Centre, Toronto

M5B 1W8

St. Michael's Hospital, Toronto

M5G 1X5

Mount Sinai Hospital, Toronto

M5T2S8

Toronto Western Hospital, Toronto

M6R1B5

Unity Health Toronto - St. Joseph's Health Centre, Toronto

H2X 0A9

Centre Hospitalier de l'Université de Montréal (CHUM), Montreal

H4A 3J1

McGill University Health Centre-Glen Site Royal Victoria Hospital, Montreal

G1J 1Z4

CHU de Québec - Université Laval, Québec

G1V 4G5

Institut Universitaire de Cardiologie et de Pneumologie de Québec- Université Laval, Québec

J1H 5N4

Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke