NCT04329494View on ClinicalTrials.gov

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

August 21, 2020

Primary Completion Date

August 5, 2026

Study Completion Date

August 5, 2026

Conditions
Clinical Stage IV Gastric Cancer AJCC v8Clinical Stage IVA Gastric Cancer AJCC v8Clinical Stage IVB Gastric Cancer AJCC v8Malignant Uterine NeoplasmMetastatic Appendix CarcinomaMetastatic Colorectal CarcinomaMetastatic Gastric CarcinomaMetastatic Malignant Neoplasm in the PeritoneumMetastatic Malignant Solid NeoplasmMetastatic Ovarian CarcinomaPathologic Stage IV Gastric Cancer AJCC v8Peritoneal CarcinomatosisPostneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8Stage IV Appendix Carcinoma AJCC v8Stage IV Colorectal Cancer AJCC v8Stage IV Ovarian Cancer AJCC v8Stage IV Uterine Corpus Cancer AJCC v8Stage IVA Appendix Carcinoma AJCC v8Stage IVA Colorectal Cancer AJCC v8Stage IVA Ovarian Cancer AJCC v8Stage IVA Uterine Corpus Cancer AJCC v8Stage IVB Appendix Carcinoma AJCC v8Stage IVB Colorectal Cancer AJCC v8Stage IVB Ovarian Cancer AJCC v8Stage IVB Uterine Corpus Cancer AJCC v8Stage IVC Appendix Carcinoma AJCC v8Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE

Biopsy

Undergo biopsy

DRUG

Cisplatin

Given via PIPAC

DRUG

Doxorubicin

Given via PIPAC

DRUG

Fluorouracil

Given IV

DEVICE

Intraperitoneal Chemotherapy

Undergo PIPAC

DRUG

Irinotecan

Given IV

DRUG

Leucovorin

Given IV

DRUG

Mitomycin

Given via PIPAC

DRUG

Oxaliplatin

Given via PIPAC

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (3)

11740

RECRUITING

Northwell Health Cancer Institute at Huntington, Greenlawn

91010

RECRUITING

City of Hope Medical Center, Duarte

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER