NCT04329065View on ClinicalTrials.gov

Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

April 20, 2022

Primary Completion Date

October 30, 2025

Study Completion Date

June 30, 2027

Conditions
Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8
Interventions
BIOLOGICAL

pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine

Given ID

DRUG

Paclitaxel

Given via infusion

BIOLOGICAL

Trastuzumab

Given IV

BIOLOGICAL

Pertuzumab

Given IV

DRUG

Docetaxel

Given IV

DRUG

Carboplatin

Given IV

PROCEDURE

Ultrasound Imaging

Undergo ultrasound imaging

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

Trial Locations (1)

98109

RECRUITING

Fred Hutch/University of Washington Cancer Consortium, Seattle

All Listed Sponsors
collaborator

United States Department of Defense

FED

lead

University of Washington

OTHER