Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome

NACompletedINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

April 1, 2020

Primary Completion Date

July 1, 2023

Study Completion Date

July 14, 2023

Conditions
Chronic Hypercapnic Respiratory FailureObesity Hypoventilation Syndrome
Interventions
DEVICE

Manual Non invasive ventilation titration

Manual Group: during a complete polysomnography, adding transcutaneous capnography and the basic ventilators curves, the ventilators setting will be adjusted in order to correct respiratory events and patient-ventilator asyncrony. A 10 hours face-to-face investigator training meeting is programmed before opening the inclusion period.

DEVICE

Automatic Non invasive ventilation titration

Automatic Group: the A40 ventilator in the automatic AVAPS mode will be adjusted in order to achieve 8-10 ml/kg of ideal weight.

Trial Locations (1)

10003

Juan F. Masa, Cáceres

All Listed Sponsors
lead

Sociedad Española de Neumología y Cirugía Torácica

OTHER

NCT04327336 - Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome | Biotech Hunter | Biotech Hunter