Twice Weekly Steroids and Exercise as Therapy for DMD

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

July 30, 2020

Primary Completion Date

September 5, 2025

Study Completion Date

October 7, 2025

Conditions
Duchenne Muscular Dystrophy (DMD)
Interventions
DRUG

Prednisone

A 12-month treatment period with twice weekly, low-dose prednisone (dose of 0.75 mg/kg per day).

BEHAVIORAL

In-home Exercise Training

For boys on current standard of care (daily glucocorticoid use), 6-months in-home, remotely supervised exercise training program involving a combination of aerobic and isometric leg strength exercises.

DRUG

Prednisone plus exercise

Twice weekly prednisone for 6 months followed by twice weekly prednisone plus exercise for 6 months.

Trial Locations (1)

32610

University of Florida, Gainesville

All Listed Sponsors
collaborator

U.S. Army Medical Research and Development Command

FED

lead

University of Florida

OTHER