Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)

PHASE2CompletedINTERVENTIONAL
Enrollment

256

Participants

Timeline

Start Date

June 15, 2020

Primary Completion Date

January 23, 2024

Study Completion Date

February 21, 2024

Conditions
Nonalcoholic Fatty Liver DiseaseNonalcoholic Steatohepatitis With Liver Fibrosis
Interventions
DRUG

Placebo

Tablet

DRUG

PF-06865571

Tablet

DRUG

PF-05221304

Tablet

Trial Locations (291)

100

National Taiwan University Hospital, Taipei

333

Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital, Taoyuan District

500

Changhua Christian Hospital, Changhua

600

Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City

704

National Cheng Kung University (NCKU) Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1407

Acibadem City Clinic MHAT Tokuda EAD, Sofia

1431

DCC Alexandrovska EOOD, Sofia

UMHAT Sv. Ivan Rilski EAD, Sofia

1797

UMHAT Sofiamed OOD, Sofia

4002

MHAT Medline Clinic AD, Plovdiv

5300

MHAT Dr. Tota Venkova AD, Gabrovo

6001

MC New Rehabilitation Center EOOD, Stara Zagora

9020

DCC Mladost-M Varna OOD, Varna

MC Leo Clinic EOOD, Varna

10029

Icahn School of Medicine at Mount Sinai/The Mount Sinai Hospital, New York

11030

Northwell Health Center for Liver Diseases, Manhasset

11217

Taipei Veterans General Hospital, Taipei

15213

UPMC - Center for Liver Diseases at the Thomas E. Starzl Institute, Pittsburgh

UPMC - Center for Liver Diseases in the Digestive Disorders Clinic, Pittsburgh

UPMC - Translational Research Center, Pittsburgh

UPMC Presbyterian Shadyside; Presbyterian Campus Pharmacy, Pittsburgh

UPMC, Pittsburgh

19107

Thomas Jefferson University, Philadelphia

20110

Manassas Clinical Research Center, Manassas

21045

Gastro Center of Maryland, Columbia

21228

Gastro Health Research, Catonsville

22031

Gastro Health Research, Fairfax

Gastro Health, LLC, Fairfax

23249

McGuire VA Medical Center, Richmond

23298

VCU Medical Center Investigational Drug Service, Richmond

Virginia Commonwealth University, Richmond

23435

Virginia Gastroenterology Clinical Research, Suffolk

23502

Digestive and Liver Disease Specialists, Norfolk

Sentara Leigh Hospital, Norfolk

27103

Gastroenterology Associates of the Piedmont, PA, Winston-Salem

Novant Health Medical Center, Winston-Salem

PMG Research of Winston-Salem, LLC, Winston-Salem

27612

M3 - Wake Research, Inc., Raleigh

29425

Medical University of South Carolina, Charleston

MUSC- Ashley River Tower, Charleston

30078

Tekton Research, Inc., Snellville

30309

Digestive Healthcare of Georgia, Atlanta

Piedmont Atlanta Hospital/Piedmont Transplant Institute, Atlanta

Piedmont Atlanta Hospital, Atlanta

30328

WR-Mount Vernon Clinical Research, LLC, Sandy Springs

31904

Columbus Regional Research Institute, Columbus

32224

Mayo Clinic Florida, Jacksonville

32751

Center for Advanced Gastroenterology, Maitland

Sandlake Imaging, Maitland

32801

Clinical Neuroscience Solutions, Inc, Orlando

32808

Omega Research Maitland, LLC, Orlando

33014

San Marcus Research Clinic, Inc., Miami Lakes

33122

Integrity Clinical Research, LLC, Doral

33125

Optimus U Corporation, Miami

33137

Unique Imaging (Biscayne Imaging Center), Miami

33142

Acevedo Clinical Research Associates, Miami

33155

Ivetmar Medical Group LLC, Miami

33156

Vascular and Interventional Specialists of Florida (Liver Biopsy), Miami

33157

Innovation Medical Research Center, Inc, Palmetto Bay

33175

Care Research Center Inc, Miami

33511

Tower Radiology (MRI-PDFF), Brandon

Tower Radiology - Parsons, Brandon

33541

AdventHealth Zephyrhills, Zephyrhills

33542

Florida Medical Clinic, LLC, Zephyrhills

33606

Radiology Associates, Tampa

33613

ForCare Clinical Research, Tampa

33702

GCP, Global Clinical Professionals, St. Petersburg

33712

Gateway (Ultrasound), St. Petersburg

33756

Gastro Florida, Clearwater

33762

Gastro Florida, Clearwater

34211

Florida Research Institute, Lakewood Rch

34239

Partners Imaging Center, Sarasota

34677

TGH Imaging Powered by Tower Radiology Center (MRI), Oldsmar

37211

Quality Medical Research, PLLC, Nashville

37212

Vanderbilt Hepatology and Liver Transplant, Nashville

Vanderbilt University Medical Center - GI Research Office, Nashville

37232

Vanderbilt University Medical Center - Digestive Disease Center, Nashville

Vanderbilt University Medical Center - Heart Station, Nashville

Vanderbilt University Medical Center - Interventional Radiology, Nashville

37421

Chattanooga Imaging Center, Chattanooga

WR-Clinsearch, LLC, Chattanooga

41944

Kyungpook National University Hospital, Daegu

42415

Yeungnam University Hospital, Daegu

44130

Paramount Medical Research & Consulting, LLC, Middleburg Heights

46112

Investigators Research Group, LLC, Brownsburg

46122

Hendricks Regional Health, Hendricks

48109

Michigan Clinical Research Unit (MCRU), Ann Arbor

University of Michigan, Ann Arbor

48202

Henry Ford Health System, Detroit

48504

Aa Mrc Llc, Flint

49241

Pusan National University Hospital, Busan

49503

Mercy Health, Grand Rapids

49505

M1 Imaging Center, Grand Rapids

49519

Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center, Wyoming

50314

MercyOne Des Moines Medical Center (Mercy Medical Center), Des Moines

50325

Heartland Medical Research, Inc. (Administrative Only), Clive

Iowa Digestive Disease Center, Clive

Iowa Radiology, Clive

52242

University of Iowa Hospitals and Clinics, Iowa City

University of Iowa Magnetic Resonance Research Facility, Iowa City

55905

Mayo Clinic, Rochester

60612

Rush University Medical Center, Chicago

65109

Jefferson City Medical Group, P.C., Jefferson City

66606

Kansas Medical Clinic PA, Topeka

67205

Alliance for Multispecialty Research, LLC, Wichita

67226

Cypress Interventional, Wichita

70072

Metropolitan Gastroenterology Associates, Marrero

Tandem Clinical Research GI, LLC, Marrero

70121

Ochsner Clinic Foundation, New Orleans

70601

Centex Studies, Inc., Lake Charles

Lake Charles Memorial Hospital, Lake Charles

71105

Louisiana Research Center, LLC, Shreveport

73112

Comprehensive Diagnostic Imaging, Oklahoma City

Digestive Disease Specialists, Inc. Endoscopy Lab, Oklahoma City

Digestive Disease Specialists, Inc., Oklahoma City

73134

Oklahoma Spine Hospital, Oklahoma City

75001

Texas Center for Interventional Surgery (Liver Biopsy Facility), Addison

75115

Center For Diagnostic Imaging, DeSoto

75203

Methodist Dallas Medical Center (MRI-PDFF), Dallas

The Liver Institute at Methodist Dallas Medical Center, Dallas

75246

Touchstone Imaging, Dallas

76012

Texas Clinical Research Institute, Arlington

76104

GI Alliance, Fort Worth

76710

Impact Research Institute, Waco

77004

Therapeutic Concepts, PA, Houston

77058

Centex Studies, Inc., Houston

77084

Biopharma Informatic, LLC, Houston

Premier Vein and Vascular, Houston

77479

Reddy Cardiac Wellness, Sugar Land

77584

HCA Houston Healthcare Pearland, Pearland

78215

American Research Corporation at the Texas Liver Institute, San Antonio

78229

Clinical Trials of Texas, Inc., San Antonio

Diabetes and Glandular Disease Clinic, P.A., San Antonio

78504

Centex Studies, Inc, McAllen

85224

Institute for Liver Health dba Arizona Liver Health, Chandler

85233

Comprehensive Interventional Care Centers (CICC), Gilbert

85306

The Institute for Liver Health, Glendale

85351

Comprehensive Interventional Care Centers (CICC), Sun City

85381

The Institute for Liver Health, Peoria

85712

Institute for Liver Health DBA Arizona Liver Health, Tucson

89104

Desert Radiology, Las Vegas

Machuca Family Medicine, Las Vegas

The Machuca Foundation, Inc., Las Vegas

89106

Sierra Clinical Research, Las Vegas

89113

Las Vegas Medical Research, Las Vegas

89118

Pueblo Medical Imaging, Las Vegas

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90048

Cedars-Sinai Advanced Health Sciences Pavilion (Imaging), Los Angeles

Cedars-Sinai Comprehensive Transplant Center, Los Angeles

Cedars-Sinai Medical Center Investigational Drug Services (Pharmacy), Los Angeles

S. Mark Taper Foundation Imaging Center (Liver Biopsy), Los Angeles

90255

National Research Institute, Huntington Park

90640

ART Vascular, Montebello

91105

California Liver Research Institute, Pasadena

HMRI, Pasadena

91303

Hope Clinical Research, Canoga Park

91345

Providence Facey Medical Foundation, Mission Hills

Providence Holy Cross Medical Center, Mission Hills

91356

Liberty Pacific Advanced Imaging, Tarzana

91436

Encino Hospital Medical Center, Encino

91786

Upland Clinical Research, Upland

92020

Magnolia Surgery Center, El Cajon

92037

Investigational Drug Service, Altman Clinical and Translational Research Institute (ACTRI), La Jolla

University of California San Diego, Altman Clinical and Translational Research Institute Clinic, La Jolla

92093

UCSD Altman Clinical and Transitional Research Institute, La Jolla

92114

Precision Research Institute, San Diego

92118

Sharp Coronado Hospital, Coronado

Southern California Research Center, Coronado

92120

WR-MCCR, San Diego

92123

Sharp and Children's MRI Center, LLC, San Diego

92377

Inland Empire Clinical Trials, LLC, Rialto

92563

United Medical Doctors, Murrieta

92660

Back Bay Imaging (Liver Biopsy), Newport Beach

92780

Orange County Research Center, Tustin

93534

A V Pediatrics, Allergy & Family Medicine, Lancaster

Jatinder S. Pruthi, M.D. FACG CPI, Lancaster

Om Research LLC, Lancaster

93551

Advanced Imaging Center, Palmdale

94063

Stanford Medicine Outpatient Center (Liver clinic/MRI), Redwood City

94304

Blake Wilbur Outpatient Clinic (MRI), Palo Alto

94305

Stanford Hospital and Clinics, Palo Alto

95124

Stanford Cancer Center South Bay (MRI), San Jose

95821

Clinical Trials Research, Sacramento

98104

Harborview Medical Center Investigational Drug Services, Seattle

Harborview Medical Center, Seattle

Seattle Radiology, Seattle

98105

Liver Institute Northwest, Seattle

98122

Swedish Medical Center, Seattle

98195

University of Washington Medical Center, Seattle

100044

Peking University People's Hospital, Beijing

100050

Beijing Friendship Hospital, Capital Medical University, Beijing

100069

Beijing YouAn Hosptial,Capital Medical University, Beijing

102218

Beijing Tsinghua Changgung Hospital, Beijing

110017

Max Smart Super Speciality Hospital, Saket

110029

All India Institute of Medical Sciences (AIIMS), New Delhi

122001

Medanta - The Medicity, Gurugram

130021

The First Bethune Hospital of Jilin University, Changchun

266042

Qingdao Central Hospital, Qingdao

300170

Tianjin Third Central Hospital, Tianjin

300192

Tianjin Second People's Hospital, Tianjin

302004

S.M.S. Medical College & Hospital, Jaipur

310000

The Affiliated Hospital of Hangzhou Normal University, Hangzhou

325000

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

395002

Surat Institute of Digestive Sciences, Surat

395009

Gujarat Hospital - Gastro and Vascular Centre, Surat

400012

Global Hospital - Super Speciality & Transplant Centre, Mumbai

410005

Hunan Provincial People's Hospital, Changsha

510080

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou

700020

Institute of Post Graduate Medical Education and Research & SSKM Hospital, Kolkata

750004

General Hospital of Ningxia Medical University, Yinchuan

3908621

Shinshu University Hospital, Matsumoto

06010

Bristol Hospital, Bristol

Bristol Radiology Center, Bristol

Connecticut Clinical Research Institute, LLC, Bristol

06510

Yale New Haven Hospital, New Haven

06511

Yale New Haven Hospital, Saint Raphael Campus (MRE location), New Haven

06519

Yale Center for Clinical Investigators, Church Street South Research Unit (CSRU), New Haven

06520

Yale Digestive Diseases (Fibroscan location), New Haven

02215

Beth Israel Deaconess Medical Center, Boston

08844

Digestive Healthcare Associates, Hillsborough

University Radiology, Hillsborough

08869

Amici Clinical Research, Raritan

02905

University Gastroenterology, Providence

02908

Roger Williams Hospital, Providence

T2N 4Z6

University of Calgary - Heritage Medical Research Clinic (HMRC), Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

T6G 2X8

University of Alberta, Edmonton

V5Z 1M9

Gordon and Leslie Diamond Health Care Centre, Vancouver

V6Z 2K5

(G.I.R.I.) GI Research Institute, Vancouver

B3H 1V7

Nova Scotia Health Authority QEII (Queen Elizabeth II) Health Sciences Centre, Halifax

N6A 2C2

Manna Research (London), London

M6H 3M1

Toronto Liver Centre, Toronto

G7H 4J1

Resonance Magnetique du Saguenay-Lac-Saint-Jean, Chicoutimi

G7H 5H6

Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean, Chicoutimi

G7H 7K9

Ecogene-21, Chicoutimi

H2X 0A9

Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal

H4A 3J1

McGill University Health Centre (MUHC), Montreal

Philips Radiation Oncology, Montreal

Research Institute of the MUHC, Montreal

G1V 4T3

Diex Recherche Quebec Inc., Québec

050051

The Third Hospital of Hebei Medical University, Shijiazhuang

Unknown

Queen Mary Hospital, Hong Kong

Prince of Wales Hospital, Shatin

Alice Ho Miu Ling Nethersole Hospital, Tai Po

110 070

Institute of Liver and Biliary Sciences (ILBS), New Delhi

480-1195

Aichi Medical University Hospital, Nagakute

791-0295

Ehime University Hospital, Tōon

503-8502

Ogaki Municipal Hospital, Ōgaki

300-0395

Tokyo Medical University Ibaraki Medical Center, Inashiki-gun

760-8557

Kagawa Prefectural Central Hospital, Takamatsu

236-0004

Yokohama City University Hospital, Yokohama

856-8562

National Hospital Organization Nagasaki Medical Center, Ohmura

591-8025

Osaka Rosai Hospital, Sakai

564-0013

Saiseikai Suita Hospital, Suita

410-2295

Juntendo University Shizuoka Hospital, Izunokuni

260-8677

Chiba University Hospital, Chiba

918-8503

Fukui-Ken Saiseikai Hospital, Fukui

500-8513

Gifu Municipal Hospital, Gifu

890-8520

Kagoshima University Hospital, Kagoshima

602-8566

University Hospital, Kyoto Prefectural University of Medicine, Kyoto

880-0003

Miyazaki Medical Center Hospital, Miyazaki

849-8501

Saga University Hospital, Saga

990-9585

Yamagata University Hospital, Yamagata

40-211

Szpital Zakonu Bonifratrow, Katowice

40-748

NZOZ Vita Longa Sp. z o.o., Katowice

40-752

Uniwersyteckie Centrum Kliniczne im. prof. K. Gibinskiego Slaskiego Uniwersytetu Medycznego, Katowice

52-229

Orthos Szpital Wielospecjalistyczny Sp. z o.o. (Liver Biopsy), Komorowice

30-688

SPZOZ Szpital Uniwersytecki w Krakowie, Krakow

31-061

Szpital Zakonu Bonifratrów św. Jana Grandego w Krakowie sp. z o.o. (Liver Biopsy), Krakow

31-501

Krakowskie Centrum Medyczne, Krakow

91-347

Wojewodzki Specjalistyczny Szpital im. Dr. Wl. Bieganskiego w Lodzi, Lodz

41-400

ID Clinic, Mysłowice

00-728

WIP Warsaw IBD Point Profesor Kierkus, Warsaw

50-088

Futuremeds Sp. z o.o., Wroclaw

22-400

ETG Zamosc, Zamość

Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II, Zamość

00909

Clinical Research Puerto Rico, San Juan

Latin Clinical Trial Center, San Juan

00917

GCM Medical Group PSC, San Juan

00927

FDI Clinical Research, San Juan

974 01

Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica, Banská Bystrica

851 01

Medispektrum, s.r.o, Bratislava

831 01

SUMMIT CLINICAL RESEARCH, s.r.o., Bratislava - Mestska Cast Nove Mesto

831 04

Lama Medical Care s.r.o., Bratislava - Mestska Cast Ruzinov

040 11

Univerzitna nemocnica L. Pasteura Kosice, Kosice - Mestska Cast Zapad

949 01

KM Management spol. s.r.o., Gastroenterologicke a hepatologicke centrum Nitra, Nitra

950 01

Fakultna nemocnica Nitra, Nitra

917 01

JAL, s.r.o., Trnava

07061

SMG-SNU Boramae Medical Center, Dongjak-gu

03722

Severance Hospital Yonsei University Health System, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY