Breath Analysis in Patients With Suspected Sarcoidosis: The VOCs-IS Study

Breath analysis using the ReCIVA device will take place during each study visit.

Full Pulmonary Function Tests will be performed at baseline and during each study visit if not performed as part of routine clinical care.

Additional voluntary consent will be sought for blood sampling and storage for genetic analysis at baseline.

Blood sampling and storage of plasma for metabolomic analysis will take place during each study visit.

Bronchoalveolar lavage will be performed at baseline on all participants undergoing investigation with bronchoscopy or EBUS as part of routine clinical care for investigation of suspected sarcoidosis.

Sputum will be collected during each study visit if the patient can spontaneously expectorate and will be sent for routine microbial analysis as well as metagenomic sequencing.

Spirometry will be performed on all healthy controls prior to enrolment into the study