1,552
Participants
Start Date
March 22, 2020
Primary Completion Date
July 9, 2022
Study Completion Date
September 25, 2023
Remdesivir
The lyophilized formulation of Remdesivir is a preservative-free, white to off-white or yellow, lyophilized solid containing 100 mg of Remdesivir to be reconstituted with 19 mL of sterile water for injection and diluted into IV infusion fluids prior to IV infusion. Following reconstitution, each vial contains a 5 mg/mL Remdesivir concentrated solution with sufficient volume to allow withdrawal of 20 mL (100 mg of remdesivir). It is supplied as a sterile product in a single-use, 30 mL, Type 1 clear glass vial.
Lopinavir/ritonavir
"The oral tablets of lopinavir/ritonavir contain 200 mg lopinavir, 50 mg ritonavir. They have a yellow colour, film-coated, ovaloid shape debossed with the a logo and the code KA. The oral solution for patients who cannot swallow is a light yellow to orange colored liquid containing 400 mg lopinavir and 100 mg ritonavir per 5 mL (80 mg lopinavir and 20 mg ritonavir per mL)."
Interferon Beta-1A
IFN-ß-1a is supplied as a sterile solution containing no preservative available in a prefilled syringe. It will be provided as a single-dose prefilled graduated syringe with 44 µg per 0.5 mL. The liquid should be clear to slightly yellow. Do not use if the liquid is cloudy, discolored or contains particles. Use a different syringe.
Hydroxychloroquine
Hydroxychloroquine is supplied as film-coated 200 mg tablets. Hydroxychloroquine sulfate tablets are presented as white or whitish, peanut-shaped, oblong or round film-coated tablets containing 200 mg of hydroxychloroquine sulfate (equivalent to 155 mg base).
Standard of care
Standard of care
AZD7442
AZD7442 will be supplied as separate vials of AZD8895 and AZD1061 containing 150 mg colorless to slightly yellow, clear to opalescent solutions for injection.
Placebo
Since April, 2021, the placebo will be a 0.9% (w/v) NaCl solution for infusion also called saline. The placebo will be supplied as a single 10-mL, clear and colorless vial.
Hôpital Erasme - Cliniques universitaires de Bruxelles, Brussels
Hôpital Saint Luc, Brussels
Hôpital La Citadelle, Liège
Landeskrankenhaus Salzburg Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Salzburg
Medizinische Universität Innsbruck, Innsbruck
Centre Hospitalier Universitaire Dijon-Bourgogne, Dijon
Centre Hospitalier Régional Universitaire de Besançon, Besançon
Centre Hospitalier Universitaire de Toulouse, Toulouse
Centre Hospitalier Universitaire de Toulouse, Toulouse
Centre Hospitalier Universitaire de Bordeaux, Bordeaux
Centre Hospitalier Universitaire de Montpellier, Montpellier
Centre Hospitalier Universitaire de Rennes, Rennes
Centre Hospitalier Universitaire de Tours, Tours
Centre Hospitalo-Universitaire de Grenoble, La Tronche
Centre Hospitalier Universitaire de Saint Etienne, Saint-Etienne
Centre Hospitalier Universitaire de Nantes, Nantes
CHU de Reims, Reims
Centre Hospitalier Régional et Universitaire de Nancy, Nancy
CH Bretagne Atlantique, Vannes
Centre Hospitalier Regional Metz-Thionville, Ars-Laquenexy
Centre Hospitalier Régional Universitaire de Lille, Lille
Centre Hospitalier de Tourcoing, Tourcoing
Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg
Groupe Hospitalier de la Région de Mulhouse Sud Alsace, Mulhouse
Hospices Civils de Lyon, Lyon
Centre Hospitalier Annecy Genevois, Épagny
APHP - Hôpital Lariboisière, Paris
APHP - Hôpital Saint Louis, Paris
APHP - Hôpital Saint Antoine, Paris
APHP - Hôpital Universitaire Pitié Salpêtrière, Paris
APHP - Hôpital Cochin, Paris
Hôpital Paris Saint-Joseph et Marie Lannelongue, Paris
APHP - Hôpital Necker, Paris
APHP- Hôpital Européen Georges-Pompidou, Paris
APHP - Hôpital Bichat Claude Bernard, Paris
APHP - Hôpital Tenon, Paris
Centre Hospitalier Universitaire Amiens-Picardie, Amiens
Hopital DELAFONTAINE, Saint-Denis
APHP - hôpital Henri-Mondor, Créteil
Hôpital d'Instruction des Armées BEGIN, Saint-Mandé
AP-HP Hôpital Bicêtre, Le Kremlin-Bicêtre
Centre Hospitalier Universitaire de Martinique, Fort de France
Centre Hospitalier Andrée Rosemon, Cayenne
Kepler Universitätsklinikum Linz, Linz
Pôle Hospitalier Jolimont / site de Mons-Warquignies, Mons
CHU APHP Ambroise-Paré, Boulogne-Billancourt
Hospices Civil, Colmar
CHU Nîmes, Nîmes
CHU Poitiers, Poitiers
CH Cornouaille, Quimper
CH Bretagne Atlantique, Vannes
Evaggelismos General Hospital, Athens
General University Hospital of Patras, Pátrai
Akershus Unniversity Hospital, Oslo
Lovisenberg Diaconal Hospital, Oslo
Oslo University Hospital, Oslo
Hospital de Cascais, Cascais
CHULN- Hospital de Santa Maria, Lisbon
Centro Hospitalar Universitário de São João, EPE, Porto
Centre Hospitalo-Universitaire de Nice, Nice
Centre Hospitalier Luxembourg, Luxembourg
Hôpitaux Robert Schuman, Luxembourg
Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV