Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

67

Participants

Timeline

Start Date

February 8, 2021

Primary Completion Date

August 1, 2026

Study Completion Date

August 1, 2028

Conditions
Recurrent T Acute Lymphoblastic LeukemiaRefractory T Acute Lymphoblastic LeukemiaRefractory T Lymphoblastic LymphomaT Lymphoblastic Lymphoma
Interventions
DRUG

AKR1C3-activated Prodrug AST-3424

Given IV

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo blood and CSF sample collection

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow aspirate

PROCEDURE

Computed Tomography

Undergo CT scan

Trial Locations (163)

14263

ACTIVE_NOT_RECRUITING

Roswell Park Cancer Institute, Buffalo

14642

RECRUITING

University of Rochester, Rochester

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23507

RECRUITING

Children's Hospital of The King's Daughters, Norfolk

26506

RECRUITING

West Virginia University Healthcare, Morgantown

27710

RECRUITING

Duke University Medical Center, Durham

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

30912

RECRUITING

Augusta University Medical Center, Augusta

33021

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33701

RECRUITING

Johns Hopkins All Children's Hospital, St. Petersburg

33908

RECRUITING

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

ACTIVE_NOT_RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

37203

RECRUITING

The Children's Hospital at TriStar Centennial, Nashville

40202

RECRUITING

Norton Children's Hospital, Louisville

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

45069

SUSPENDED

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

48201

ACTIVE_NOT_RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48334

ACTIVE_NOT_RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

RECRUITING

West Michigan Cancer Center, Kalamazoo

49009

RECRUITING

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

RECRUITING

Bronson Battle Creek, Battle Creek

49048

RECRUITING

Beacon Kalamazoo, Kalamazoo

49085

RECRUITING

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

RECRUITING

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

RECRUITING

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

RECRUITING

Trinity Health Muskegon Hospital, Muskegon

RECRUITING

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

RECRUITING

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

RECRUITING

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

RECRUITING

University of Michigan Health - West, Wyoming

49677

RECRUITING

Corewell Health Reed City Hospital, Reed City

49684

RECRUITING

Munson Medical Center, Traverse City

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

54017

ACTIVE_NOT_RECRUITING

Cancer Center of Western Wisconsin, New Richmond

54601

ACTIVE_NOT_RECRUITING

Gundersen Lutheran Medical Center, La Crosse

55008

ACTIVE_NOT_RECRUITING

Cambridge Medical Center, Cambridge

55082

ACTIVE_NOT_RECRUITING

Lakeview Hospital, Stillwater

55092

ACTIVE_NOT_RECRUITING

Fairview Lakes Medical Center, Wyoming

55101

ACTIVE_NOT_RECRUITING

Regions Hospital, Saint Paul

55102

ACTIVE_NOT_RECRUITING

United Hospital, Saint Paul

55109

ACTIVE_NOT_RECRUITING

Minnesota Oncology Hematology PA-Maplewood, Maplewood

ACTIVE_NOT_RECRUITING

Saint John's Hospital - Healtheast, Maplewood

55125

ACTIVE_NOT_RECRUITING

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

ACTIVE_NOT_RECRUITING

Fairview Ridges Hospital, Burnsville

ACTIVE_NOT_RECRUITING

Minnesota Oncology - Burnsville, Burnsville

55362

ACTIVE_NOT_RECRUITING

Monticello Cancer Center, Monticello

55369

ACTIVE_NOT_RECRUITING

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

ACTIVE_NOT_RECRUITING

Fairview Northland Medical Center, Princeton

55379

ACTIVE_NOT_RECRUITING

Saint Francis Regional Medical Center, Shakopee

55387

ACTIVE_NOT_RECRUITING

Ridgeview Medical Center, Waconia

55407

ACTIVE_NOT_RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55415

ACTIVE_NOT_RECRUITING

Hennepin County Medical Center, Minneapolis

55416

ACTIVE_NOT_RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

ACTIVE_NOT_RECRUITING

North Memorial Medical Health Center, Robbinsdale

55432

ACTIVE_NOT_RECRUITING

Unity Hospital, Fridley

55433

ACTIVE_NOT_RECRUITING

Mercy Hospital, Coon Rapids

55435

ACTIVE_NOT_RECRUITING

Fairview Southdale Hospital, Edina

55454

ACTIVE_NOT_RECRUITING

Health Partners Inc, Minneapolis

55455

RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

56073

ACTIVE_NOT_RECRUITING

New Ulm Medical Center, New Ulm

56201

ACTIVE_NOT_RECRUITING

Rice Memorial Hospital, Willmar

60045

ACTIVE_NOT_RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60153

ACTIVE_NOT_RECRUITING

Loyola University Medical Center, Maywood

60160

ACTIVE_NOT_RECRUITING

Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park

60451

ACTIVE_NOT_RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

ACTIVE_NOT_RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60491

ACTIVE_NOT_RECRUITING

Loyola Medicine Homer Glen, Homer Glen

60527

ACTIVE_NOT_RECRUITING

Loyola Center for Health at Burr Ridge, Burr Ridge

60611

RECRUITING

Lurie Children's Hospital-Chicago, Chicago

RECRUITING

Northwestern University, Chicago

60612

RECRUITING

University of Illinois, Chicago

60637

ACTIVE_NOT_RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70805

RECRUITING

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

RECRUITING

Our Lady of the Lake Physician Group, Baton Rouge

78229

RECRUITING

Methodist Children's Hospital of South Texas, San Antonio

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

79905

RECRUITING

El Paso Children's Hospital, El Paso

80045

RECRUITING

Children's Hospital Colorado, Aurora

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

86401

RECRUITING

Kingman Regional Medical Center, Kingman

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

89048

RECRUITING

Hope Cancer Care of Nevada-Pahrump, Pahrump

89052

RECRUITING

Cancer and Blood Specialists-Henderson, Henderson

RECRUITING

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

RECRUITING

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson

SUSPENDED

Las Vegas Cancer Center-Henderson, Henderson

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89074

RECRUITING

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

RECRUITING

GenesisCare USA - Henderson, Henderson

RECRUITING

Las Vegas Urology - Green Valley, Henderson

RECRUITING

Las Vegas Urology - Pebble, Henderson

RECRUITING

Urology Specialists of Nevada - Green Valley, Henderson

RECRUITING

Las Vegas Urology - Pecos, Las Vegas

89102

SUSPENDED

Desert West Surgery, Las Vegas

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

RECRUITING

University Medical Center of Southern Nevada, Las Vegas

89103

RECRUITING

Hope Cancer Care of Nevada, Las Vegas

89106

RECRUITING

Radiation Oncology Centers of Nevada Central, Las Vegas

RECRUITING

Urology Specialists of Nevada - Central, Las Vegas

89109

RECRUITING

GenesisCare USA - Las Vegas, Las Vegas

SUSPENDED

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas

RECRUITING

Sunrise Hospital and Medical Center, Las Vegas

89113

SUSPENDED

HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas

RECRUITING

Las Vegas Prostate Cancer Center, Las Vegas

RECRUITING

Las Vegas Urology - Sunset, Las Vegas

RECRUITING

Urology Specialists of Nevada - Southwest, Las Vegas

89119

RECRUITING

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89128

RECRUITING

Ann M Wierman MD LTD, Las Vegas

RECRUITING

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

RECRUITING

GenesisCare USA - Vegas Tenaya, Las Vegas

SUSPENDED

HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas

RECRUITING

Las Vegas Urology - Cathedral Rock, Las Vegas

RECRUITING

Las Vegas Urology - Smoke Ranch, Las Vegas

RECRUITING

OptumCare Cancer Care at MountainView, Las Vegas

RECRUITING

Urology Specialists of Nevada - Northwest, Las Vegas

89135

RECRUITING

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

89144

RECRUITING

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas

RECRUITING

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

RECRUITING

Summerlin Hospital Medical Center, Las Vegas

89148

RECRUITING

Comprehensive Cancer Centers of Nevada, Las Vegas

RECRUITING

GenesisCare USA - Fort Apache, Las Vegas

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

89149

SUSPENDED

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas

89169

RECRUITING

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

RECRUITING

University Cancer Center, Las Vegas

89502

RECRUITING

Renown Regional Medical Center, Reno

89503

RECRUITING

Saint Mary's Regional Medical Center, Reno

89509

RECRUITING

Radiation Oncology Associates, Reno

89703

RECRUITING

Carson Tahoe Regional Medical Center, Carson City

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

92868

RECRUITING

Children's Hospital of Orange County, Orange

93420

RECRUITING

PCR Oncology, Arroyo Grande

97239

ACTIVE_NOT_RECRUITING

Oregon Health and Science University, Portland

98004

SUSPENDED

Overlake Medical Center, Bellevue

98055

RECRUITING

Valley Medical Center, Renton

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

98195

RECRUITING

University of Washington Medical Center - Montlake, Seattle

98902

RECRUITING

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

89148-2405

SUSPENDED

Las Vegas Cancer Center-Medical Center, Las Vegas

02903

RECRUITING

Rhode Island Hospital, Providence

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK