67
Participants
Start Date
February 8, 2021
Primary Completion Date
August 1, 2026
Study Completion Date
August 1, 2028
AKR1C3-activated Prodrug AST-3424
Given IV
Biopsy Procedure
Undergo biopsy
Biospecimen Collection
Undergo blood and CSF sample collection
Bone Marrow Aspiration
Undergo bone marrow aspirate
Computed Tomography
Undergo CT scan
ACTIVE_NOT_RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
University of Rochester, Rochester
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
West Virginia University Healthcare, Morgantown
RECRUITING
Duke University Medical Center, Durham
RECRUITING
Prisma Health Richland Hospital, Columbia
RECRUITING
Emory University Hospital/Winship Cancer Institute, Atlanta
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Augusta University Medical Center, Augusta
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Johns Hopkins All Children's Hospital, St. Petersburg
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
ACTIVE_NOT_RECRUITING
University of Alabama at Birmingham Cancer Center, Birmingham
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
Norton Children's Hospital, Louisville
RECRUITING
Cleveland Clinic Foundation, Cleveland
SUSPENDED
University of Cincinnati Cancer Center-West Chester, West Chester
RECRUITING
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
ACTIVE_NOT_RECRUITING
Wayne State University/Karmanos Cancer Institute, Detroit
ACTIVE_NOT_RECRUITING
Weisberg Cancer Treatment Center, Farmington Hills
RECRUITING
Bronson Methodist Hospital, Kalamazoo
RECRUITING
West Michigan Cancer Center, Kalamazoo
RECRUITING
Beacon Kalamazoo Cancer Center, Kalamazoo
RECRUITING
Bronson Battle Creek, Battle Creek
RECRUITING
Beacon Kalamazoo, Kalamazoo
RECRUITING
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
RECRUITING
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
RECRUITING
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
RECRUITING
Trinity Health Muskegon Hospital, Muskegon
RECRUITING
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
RECRUITING
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
Trinity Health Grand Rapids Hospital, Grand Rapids
RECRUITING
University of Michigan Health - West, Wyoming
RECRUITING
Corewell Health Reed City Hospital, Reed City
RECRUITING
Munson Medical Center, Traverse City
RECRUITING
Mary Greeley Medical Center, Ames
RECRUITING
McFarland Clinic - Ames, Ames
RECRUITING
McFarland Clinic - Boone, Boone
RECRUITING
McFarland Clinic - Jefferson, Jefferson
RECRUITING
McFarland Clinic - Marshalltown, Marshalltown
RECRUITING
McFarland Clinic - Trinity Cancer Center, Fort Dodge
ACTIVE_NOT_RECRUITING
Cancer Center of Western Wisconsin, New Richmond
ACTIVE_NOT_RECRUITING
Gundersen Lutheran Medical Center, La Crosse
ACTIVE_NOT_RECRUITING
Cambridge Medical Center, Cambridge
ACTIVE_NOT_RECRUITING
Lakeview Hospital, Stillwater
ACTIVE_NOT_RECRUITING
Fairview Lakes Medical Center, Wyoming
ACTIVE_NOT_RECRUITING
Regions Hospital, Saint Paul
ACTIVE_NOT_RECRUITING
United Hospital, Saint Paul
ACTIVE_NOT_RECRUITING
Minnesota Oncology Hematology PA-Maplewood, Maplewood
ACTIVE_NOT_RECRUITING
Saint John's Hospital - Healtheast, Maplewood
ACTIVE_NOT_RECRUITING
Minnesota Oncology Hematology PA-Woodbury, Woodbury
ACTIVE_NOT_RECRUITING
Fairview Ridges Hospital, Burnsville
ACTIVE_NOT_RECRUITING
Minnesota Oncology - Burnsville, Burnsville
ACTIVE_NOT_RECRUITING
Monticello Cancer Center, Monticello
ACTIVE_NOT_RECRUITING
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
ACTIVE_NOT_RECRUITING
Fairview Northland Medical Center, Princeton
ACTIVE_NOT_RECRUITING
Saint Francis Regional Medical Center, Shakopee
ACTIVE_NOT_RECRUITING
Ridgeview Medical Center, Waconia
ACTIVE_NOT_RECRUITING
Abbott-Northwestern Hospital, Minneapolis
ACTIVE_NOT_RECRUITING
Hennepin County Medical Center, Minneapolis
ACTIVE_NOT_RECRUITING
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
ACTIVE_NOT_RECRUITING
North Memorial Medical Health Center, Robbinsdale
ACTIVE_NOT_RECRUITING
Unity Hospital, Fridley
ACTIVE_NOT_RECRUITING
Mercy Hospital, Coon Rapids
ACTIVE_NOT_RECRUITING
Fairview Southdale Hospital, Edina
ACTIVE_NOT_RECRUITING
Health Partners Inc, Minneapolis
RECRUITING
University of Minnesota/Masonic Cancer Center, Minneapolis
ACTIVE_NOT_RECRUITING
New Ulm Medical Center, New Ulm
ACTIVE_NOT_RECRUITING
Rice Memorial Hospital, Willmar
ACTIVE_NOT_RECRUITING
Northwestern Medicine Lake Forest Hospital, Lake Forest
ACTIVE_NOT_RECRUITING
Loyola University Medical Center, Maywood
ACTIVE_NOT_RECRUITING
Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park
ACTIVE_NOT_RECRUITING
UC Comprehensive Cancer Center at Silver Cross, New Lenox
ACTIVE_NOT_RECRUITING
University of Chicago Medicine-Orland Park, Orland Park
ACTIVE_NOT_RECRUITING
Loyola Medicine Homer Glen, Homer Glen
ACTIVE_NOT_RECRUITING
Loyola Center for Health at Burr Ridge, Burr Ridge
RECRUITING
Lurie Children's Hospital-Chicago, Chicago
RECRUITING
Northwestern University, Chicago
RECRUITING
University of Illinois, Chicago
ACTIVE_NOT_RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
LSU Health Baton Rouge-North Clinic, Baton Rouge
RECRUITING
Our Lady of the Lake Physician Group, Baton Rouge
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Huntsman Cancer Institute/University of Utah, Salt Lake City
RECRUITING
Kingman Regional Medical Center, Kingman
RECRUITING
University of New Mexico Cancer Center, Albuquerque
RECRUITING
Hope Cancer Care of Nevada-Pahrump, Pahrump
RECRUITING
Cancer and Blood Specialists-Henderson, Henderson
RECRUITING
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
RECRUITING
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
SUSPENDED
Las Vegas Cancer Center-Henderson, Henderson
RECRUITING
OptumCare Cancer Care at Seven Hills, Henderson
RECRUITING
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
RECRUITING
GenesisCare USA - Henderson, Henderson
RECRUITING
Las Vegas Urology - Green Valley, Henderson
RECRUITING
Las Vegas Urology - Pebble, Henderson
RECRUITING
Urology Specialists of Nevada - Green Valley, Henderson
RECRUITING
Las Vegas Urology - Pecos, Las Vegas
SUSPENDED
Desert West Surgery, Las Vegas
RECRUITING
OptumCare Cancer Care at Charleston, Las Vegas
RECRUITING
University Medical Center of Southern Nevada, Las Vegas
RECRUITING
Hope Cancer Care of Nevada, Las Vegas
RECRUITING
Radiation Oncology Centers of Nevada Central, Las Vegas
RECRUITING
Urology Specialists of Nevada - Central, Las Vegas
RECRUITING
GenesisCare USA - Las Vegas, Las Vegas
SUSPENDED
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas
RECRUITING
Sunrise Hospital and Medical Center, Las Vegas
SUSPENDED
HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas
RECRUITING
Las Vegas Prostate Cancer Center, Las Vegas
RECRUITING
Las Vegas Urology - Sunset, Las Vegas
RECRUITING
Urology Specialists of Nevada - Southwest, Las Vegas
RECRUITING
Radiation Oncology Centers of Nevada Southeast, Las Vegas
RECRUITING
Ann M Wierman MD LTD, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
RECRUITING
GenesisCare USA - Vegas Tenaya, Las Vegas
SUSPENDED
HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas
RECRUITING
Las Vegas Urology - Cathedral Rock, Las Vegas
RECRUITING
Las Vegas Urology - Smoke Ranch, Las Vegas
RECRUITING
OptumCare Cancer Care at MountainView, Las Vegas
RECRUITING
Urology Specialists of Nevada - Northwest, Las Vegas
RECRUITING
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
RECRUITING
Summerlin Hospital Medical Center, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada, Las Vegas
RECRUITING
GenesisCare USA - Fort Apache, Las Vegas
RECRUITING
OptumCare Cancer Care at Fort Apache, Las Vegas
SUSPENDED
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
RECRUITING
University Cancer Center, Las Vegas
RECRUITING
Renown Regional Medical Center, Reno
RECRUITING
Saint Mary's Regional Medical Center, Reno
RECRUITING
Radiation Oncology Associates, Reno
RECRUITING
Carson Tahoe Regional Medical Center, Carson City
RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Children's Hospital of Orange County, Orange
RECRUITING
PCR Oncology, Arroyo Grande
ACTIVE_NOT_RECRUITING
Oregon Health and Science University, Portland
SUSPENDED
Overlake Medical Center, Bellevue
RECRUITING
Valley Medical Center, Renton
RECRUITING
Fred Hutchinson Cancer Center, Seattle
RECRUITING
University of Washington Medical Center - Montlake, Seattle
RECRUITING
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
RECRUITING
Arkansas Children's Hospital, Little Rock
SUSPENDED
Las Vegas Cancer Center-Medical Center, Las Vegas
RECRUITING
Rhode Island Hospital, Providence
National Cancer Institute (NCI)
NIH
SWOG Cancer Research Network
NETWORK