Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

146

Participants

Timeline

Start Date

June 26, 2020

Primary Completion Date

October 6, 2025

Study Completion Date

October 6, 2025

Conditions
Melanoma
Interventions
BIOLOGICAL

Pembrolizumab

Administered via IV infusion at a specified dose on specified days

BIOLOGICAL

Vibostolimab

Administered via IV infusion at a specified dose on specified days

BIOLOGICAL

Gebasaxturev

Administered via IT injection at a specified dose on specified days

BIOLOGICAL

MK-4830

Administered via IV infusion at a specified dose on specified days

BIOLOGICAL

Favezelimab + Pembrolizumab

Administered via IV infusion at a specified dose on specified days

DRUG

ATRA

Administered via oral capsules at a specified dose on specified days

Trial Locations (29)

1011

CHUV Centre Hospitalier Universitaire Vaudois ( Site 3602), Lausanne

1211

Hôpitaux Universitaires de Genève (HUG)-Oncology ( Site 3603), Geneva

2065

Melanoma Institute Australia ( Site 3402), Wollstonecraft

4215

Tasman Oncology Research Pty Ltd ( Site 3403), Southport

6150

Fiona Stanley Hospital ( Site 3401), Murdoch

8058

Universitaetsspital Zuerich ( Site 3601), Zuerich Flughafen

10016

NYU Clinical Cancer Center ( Site 3002), New York

13005

Hopital La Timone ( Site 3103), Marseille

19104

University of Pennsylvania Abramson Cancer Center ( Site 3008), Philadelphia

20141

Istituto Europeo di Oncologia ( Site 3301), Milan

21287

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 3022), Baltimore

22031

Inova Schar Cancer Institute ( Site 3011), Fairfax

27710

Duke Cancer Institute ( Site 3005), Durham

31059

Institut Claudius Regaud ( Site 3105), Toulouse

38138

West Cancer Center - East Campus ( Site 3014), Germantown

43221

Martha Morehouse Tower ( Site 3020), Columbus

53100

Policlinico Le Scotte - A.O. Senese ( Site 3377), Siena

69495

Centre Hospitalier Lyon Sud ( Site 3102), Pierre-Bénite

75010

A.P.H. Paris, Hopital Saint Louis ( Site 3107), Paris

80045

University of Colorado, Anschutz Cancer Pavilion ( Site 3012), Aurora

90025

The Angeles Clinic and Research Institute ( Site 3009), Los Angeles

90404

Providence Saint John's Health Center ( Site 3010), Santa Monica

94805

Gustave Roussy ( Site 3101), Villejuif

97239

Oregon Health & Science University ( Site 3013), Portland

1834111

HaEmek Medical Center ( Site 3703), Afula

3109601

Rambam Health Care Campus-Oncology ( Site 3704), Haifa

4941492

Rabin Medical Center-Oncology ( Site 3705), Petah Tikva

5265601

Chaim Sheba Medical Center ( Site 3701), Ramat Gan

9112001

Hadassah Ein Karem Jerusalem ( Site 3702), Jerusalem

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04303169 - Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02) | Biotech Hunter | Biotech Hunter