Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

1,150

Participants

Timeline

Start Date

February 27, 2020

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2030

Conditions
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Interventions
DRUG

Memantine Hydrochloride Oral Solution

Memantine hydrocholoride taken once daily

DRUG

Trazodone Hydrochloride oral solution

Trazodone Hydrochloride taken once daily

DRUG

Placebo oral solution

Placebo taken once daily

DRUG

Amantadine Hydrochloride Oral Solution

Amantadine Hydrochloride taken once daily

DRUG

Tacrolimus 1Mg Cap

Tacrolimus 1Mg overencapsulated tablet taken once daily

DRUG

Placebo capsule

Placebo taken once daily

Trial Locations (22)

BT63 5QQ

RECRUITING

Southern Health and Social Care Trust, Craigavon Area Hospital, Portadown

Unknown

RECRUITING

Aberdeen Royal Infirmary, Aberdeen

RECRUITING

University Hospitals Sussex NHS Foundation Trust, Brighton

RECRUITING

Clinical Research Centre , Ninewells Hospital, Dundee

RECRUITING

Royal Devon and Exeter Hospital, Exeter

RECRUITING

Queen Elizabeth University Hospital Clinical Research Facility, Glasgow

RECRUITING

NHS Highland Clinical Research Facility, Raigmore Hospital, Inverness

RECRUITING

King's College Hospital NHS Foundation Trust, London

RECRUITING

University Hospitals of Dorset NHS Trust, Poole

RECRUITING

Clinical Research Facility Salford Royal NHS Foundation Trust, Salford

RECRUITING

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

RECRUITING

Clinical Research Facility University Hospital Southampton, Southampton

B15 2TH

RECRUITING

University Hospitals of Birmingham NHS Foundation Trust, Birmingham

IP33 2QZ

RECRUITING

West Suffolk NHS Foundation Trust, Bury St Edmunds

CB2 0QQ

RECRUITING

Cambridge University Hospitals NHS Foundation Trust, Cambridge

CF14 4XW

RECRUITING

Cardiff and Vale University Local Health Board, Cardiff

EH16 4SB

RECRUITING

Anne Rowling Regenerative Neurology Clinic, Edinburgh

CO4 5JL

RECRUITING

East Suffolk and North Essex NHS Foundation Trust, Ipswich

E1 1FR

RECRUITING

Royal London Hospital, London

SW17 0QT

RECRUITING

St George's University Hospitals NHS Foundation Trust, London

NE7 7DN

RECRUITING

Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

NR4 7UY

RECRUITING

Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich

All Listed Sponsors
collaborator

University College, London

OTHER

collaborator

University of Warwick

OTHER

collaborator

NHS Lothian

OTHER_GOV

lead

University of Edinburgh

OTHER