300
Participants
Start Date
May 14, 2020
Primary Completion Date
May 31, 2026
Study Completion Date
May 31, 2028
Prospective cohort
"Immunohistochemical determinations: Cell of Origin (COO) (according with Hans algorithm), evaluation of Cluster of Differentiation (CD) (CD20, CD5, CD10), Bcl6, Bcl2 (cut off\>50%), MUM1/IRF4, c-myc (cut off\>40%) and Ki67, FISH for c-myc and if rearranged for Bcl2 e Bcl6.~mRNA expression by Nanostring Single cell analysis Immune checkpoint expression Proteomic analysis Metabolic analysis Radiomic analysis"
Retrospective cohort
"Immunohistochemical determinations: Cell of Origin (COO) (according with Hans algorithm), evaluation of Cluster of Differentiation (CD) (CD20, CD5, CD10), Bcl6, Bcl2 (cut off\>50%), MUM1/IRF4, c-myc (cut off\>40%) and Ki67, FISH for c-myc and if rearranged for Bcl2 e Bcl6.~mRNA expression by Nanostring Single cell analysis Immune checkpoint expression Proteomic analysis Metabolic analysis Radiomic analysis"
RECRUITING
Irst Irccs, Meldola
RECRUITING
Ospedale Infermi, Rimini
RECRUITING
Ospedale S. Maria delle Croci RAVENNA, Ravenna
RECRUITING
L'Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola-Malpighi, Bologna
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
OTHER