Doravirine/Islatravir (DOR/ISL) in Pediatric Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are <18 Years of Age and Weigh ≥35 kg (MK-8591A-028)

PHASE2CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

November 26, 2020

Primary Completion Date

December 21, 2021

Study Completion Date

January 25, 2023

Conditions
HIV-1 Infection
Interventions
DRUG

DOR/ISL

100 mg DOR/0.75 mg ISL FDC tablet taken once daily by mouth.

Trial Locations (17)

1864

Perinatal HIV Research Unit ( Site 1902), Johannesburg

2000

Wits Reproductive Health and HIV Institute (WRHI) ( Site 1903), Johannesburg

2093

Empilweni Services and Research Unit ( Site 1904), Johannesburg

4001

King Edward Hospital ( Site 1900), Durban

10330

Chulalongkorn University ( Site 1602), Bangkok

10700

Siriraj Hospital ( Site 1601), Bangkok

20010

Children's National Medical Center ( Site 1816), Washington D.C.

20157

Azienda Ospedaliera Luigi Sacco ( Site 1300), Milan

21287

Johns Hopkins University ( Site 1800), Baltimore

27705

Duke University ( Site 1807), Durham

30322

Emory Children's Center ( Site 1805), Atlanta

50200

Research Institute for Health Sciences ( Site 1603), Chiang Mai

105275

Infectious Clinical Hospital #2 ( Site 1501), Moscow

196645

FGU Republican Clinical Infectious Hospital of Roszdrav ( Site 1500), Saint Petersburg

410009

Saratov Regional Clinical Center for Prophylaxis and Control of AIDS ( Site 1505), Saratov

660049

Krasnoyarsk Regional Center for Prevention and Control of AIDS ( Site 1507), Krasnoyarsk

00165

IRCCS Ospedale Pediatrico Bambino Gesu ( Site 1301), Roma

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04295772 - Doravirine/Islatravir (DOR/ISL) in Pediatric Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are <18 Years of Age and Weigh ≥35 kg (MK-8591A-028) | Biotech Hunter | Biotech Hunter