A Study of Tiragolumab in Combination With Atezolizumab Compared With Placebo in Combination With Atezolizumab in Patients With Previously Untreated Locally Advanced Unresectable or Metastatic PD-L1-Selected Non-Small Cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

620

Participants

Timeline

Start Date

March 4, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Atezolizumab

Atezolizumab 1200 milligrams (mg) administered by intravenous (IV) infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Tiragolumab

Tiragolumab 600 mg administered by IV infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Matching Placebo

Matching Placebo administered by IV infusion Q3W on Day 1 of each 21-day cycle.

Trial Locations (140)

112

Taipei Veterans General Hospital, Taipei

407

Taichung Veterans General Hospital, Taichung

704

National Cheng Kung Uni Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1011

CHUV, Lausanne

1121

Orszagos Koranyi TBC es Pulmonologiai Intezet, Budapest

1140

Klinik Penzing, Vienna

1210

Krankenhaus Nord - Klinik Floridsdorf, Vienna

3000

Peter Maccallum Cancer Centre, Melbourne

3010

Inselspital Bern, Bern

3084

Austin Hospital Olivia Newton John Cancer Centre, Heidelberg

3233

Matrai Gyogyintezet, Mátraháza

4020

Ordensklinikum Linz Elisabethinen, Linz

4102

Princess Alexandra Hospital, Woolloongabba

5004

Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház, Szolnok

5154

Instituto Regional de Enfermedades Neoplásicas del Sur, Arequipa

6351

Samsung Medical Center, Seoul

9000

Kantonsspital St.Gallen Medizin Onkologie, Sankt Gallen

10043

Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano

10048

National Taiwan University Hospital, Zhongzheng Dist.

10330

Chulalongkorn Hospital, Bangkok

10400

Ramathibodi Hospital, Bangkok

10700

Faculty of Med. Siriraj Hosp., Bangkok

11000

Clinical Center of Serbia, Belgrade

11080

University Hospital Medical Center Bezanijska kosa, Belgrade

13620

Seoul National University Bundang Hospital, Gyeonggi-do

15038

Instituto Nacional de Enfermedades Neoplasicas, Lima

16499

Ajou University Medical Center, Gyeonggi-do

20089

Istituto Clinico Humanitas, Rozzano

20141

Irccs Istituto Europeo di Oncologia (IEO), Milan

20900

Asst Di Monza, Monza

21565

Gachon University Gil Medical Center, Incheon

22031

Virginia Cancer Specialists (Fairfax) - USOR, Fairfax

22927

LungenClinic Großhansdorf GmbH, Großhansdorf

23561

Taipei Medical University ?Shuang Ho Hospital, New Taipei City

24153

Onc & Hem Assoc SW Virginia, Salem

28041

Hospital 12 de Octubre, Madrid

28222

Hospital Universitario Puerta de Hierro - Majadahonda, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

29010

Hospital Regional Universitario de Malaga, Málaga

32308

SCRI Florida Cancer Specialists PAN, Tallahassee

33305

Chang Gung Memorial Hospital - Linkou Branch, Guishan Dist.

33705

SCRI Florida Cancer Specialists North, St. Petersburg

34098

Istanbul University Cerrahpasa Faculty of Medicine, Istanbul

34722

Goztepe Prof.Dr. Suleyman Yalcin City Hospital, Kadiköy

35110

Izmir Dr. Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi, Izmir

35128

IOV - Istituto Oncologico Veneto - IRCCS, Padua

37203

SCRI Oncology Partners, Nashville

41013

Hospital Universitario Virgen del Rocío, Madrid

44280

Inonu University Medical Faculty of Medicine, Malatya

48153

Gemeinschaftspraxis für Hämatologie und Onkologie, Münster

49102

City Clinical Hospital #4, Dnipropetrovsk

50009

Hosp Clinico Univ Lozano Blesa, Zaragoza

50048

ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council, Kryvyi Rih

55102

US oncology research at Minnesota Oncology, Saint Paul

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

60488

Krankenhaus Nordwest, Frankfurt

64710

AVIX Investigación Clínica S.C, Monterrey

70376

Klinik Schillerhöhe, Stuttgart

74245

SLK Kliniken Heilbronn GmbH, Standort Fachklinik Löwenstein, Löwenstein

76000

Cuidados oncologicos, Querétaro City

76018

Ivano-Frankivsk Regional Oncology Center, Ivano-Frankivsk

80131

Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale, Napoli

80220

Rocky Mountain Cancer Center - Denver, Denver

83100

Azienda Ospedaliera San Giuseppe Moscati, Avellino

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

88000

Uzhgorod Nat. University Central Municip Hosp, Uzhhorod

90110

Songklanagarind Hospital, Songkhla

98684

Northwest Cancer Specialists - Vancouver, Vancouver

100142

Beijing Cancer Hospital, Beijing

105229

Main Military Clinical Hospital named after N.N. Burdenko, Moscow

130021

The First Hospital of Jilin University, Changchun

143422

MEDSI Clinical Hospital on Pyatnitsky Highway, Moscow

150081

Harbin Medical University Cancer Hospital, Harbin

189646

Institute of Oncology, Saint Petersburg

194291

Leningrad Regional Clinical Hospital, Saint Petersburg

197089

St. Petersburg Med Univ, Saint Petersburg

197758

St. Petersburg Clinical Scientific Center of special services medical assis (oncology), Saint Petersburg

200032

Zhongshan Hospital Fudan University, Shanghai

200120

Fudan University Shanghai Cancer Center, Shanghai

200433

Shanghai Pulmonary Hospital, Shanghai

226361

Nantong Tumor Hospital, Nantong

250013

Jinan Central Hospital, Jinan

310016

Sir Run Run Shaw Hospital Zhejiang University, Hangzhou

310022

Zhejiang Cancer Hospital, Zhejiang

330200

The 1st Affiliated Hospital of Nanchang Unversity, Nanchang

350014

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

400030

Chongqing Cancer Hospital, Chongqing

430022

Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan

514031

Meizhou People's Hospital, Meizhou

570311

Hainan General Hospital, Haikou

610041

West China Hospital, Sichuan University, Chengdu

710061

First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an

06520

Yale Cancer Center, New Haven

98700-000

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí

14784-400

Hospital de Cancer de Barretos, Barretos

06120

Krankenhaus Martha-Maria Halle-Doelau gGmbH, Halle

104 31

Sotiria Hospital, Athens

185 47

Metropolitan Hospital, Athens

411 10

University Hospital of Larissa, Larissa

570 01

Diavalkaniko Hospital, Thessaloniki

00151

Azienda Ospedaliera San Camillo Forlanini, Rome

00168

"Policlinico Universitario Agostino Gemelli", Rome

06156

Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia, Perugia

464-8681

Aichi Cancer Center, Aichi

277-8577

National Cancer Center Hospital East, Chiba

812-8582

Kyushu University Hospital, Fukuoka

980-0873

Sendai Kousei Hospital, Miyagi

951-8566

Niigata Cancer Center Hospital, Niigata

541-8567

Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Osaka

362-0806

Saitama Cancer Center, Saitama

591-8555

NHO Kinki-Chuo Chest Medical Center, Sakaishi

411-8777

Shizuoka Cancer Center, Shizuoka

104-0045

National Cancer Center Hospital, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

03810

Health Pharma Professional Research, CD Mexico

06100

Cryptex Investigacion Clinica SA de CV, México

Hacettepe University Medical Faculty, Ankara

5223 GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

6716 RP

Ziekenhuis Gelderse Vallei, Ede

8934 AD

Medisch Centrum Leeuwarden, Leeuwarden

2545 AA

Hagaziekenhuis, locatie Leyweg, The Hague

Lima 41

Clinica Internacional, Sede San Borja, Lima

Lima 27

Clinica Ricardo Palma, San Isidro

10-357

Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn

05-400

Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy, Otwock

60-569

Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Medical Center, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

442-723

St. Vincent's Hospital, Suwon

08916

Hospital Universitario Germans Trias i Pujol, Badalona

03010

Hospital General Universitario de Alicante, Alicante

08035

Hospital Universitari Vall d'Hebron, Barcelona

01120

Adana Baskent University Hospital, Adana

01140

Medical Park Seyhan Hospital, Seyhan

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY