Adaptive COVID-19 Treatment Trial (ACTT)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,062

Participants

Timeline

Start Date

February 21, 2020

Primary Completion Date

May 21, 2020

Study Completion Date

May 21, 2020

Conditions
COVID-19
Interventions
OTHER

Placebo

The supplied placebo lyophilized formulation is identical in physical appearance to the active lyophilized formulation and contains the same inactive ingredients. Alternatively, a placebo of normal saline of equal volume may be given if there are limitations on matching placebo supplies.

DRUG

Remdesivir

Drug Remdesivir is a single diastereomer monophosphoramidate prodrug designed for the intracellular delivery of a modified adenine nucleoside analog GS-441524. In addition to the active ingredient, the lyophilized formulation of Remdesivir contains the following inactive ingredients: water for injection, sulfobutylether beta-cyclodextrin sodium (SBECD), and hydrochloric acid and/or sodium hydroxide.

Trial Locations (60)

2100

University of Copenhagen - Centre of Excellence for Health, Immunity and Infections (CHIP) - Department of Infectious Diseases, Copenhagen

13620

Seoul National University Bundang Hospital - Division of Infectious Diseases, Bundang-gu Seongnam-si

14080

Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán - Departamento de Infectologia, Mexico City

Instituto Nacional de Enfermedades Respiratorias (INER) - Ismael Cosío Villegas, Mexico City

17033

Penn State Health Milton S. Hershey Medical Center - Division of Infectious Diseases, Hershey

20889

Walter Reed National Military Medical Center, Bethesda

23708

Naval Medical Center Portsmouth - Infectious Disease Division, Portsmouth

27704

Duke Human Vaccine Institute - Duke Vaccine and Trials Unit, Durham

29037

University of California San Diego Health - Jacobs Medical Center, La Jolla

35233

University of Alabama at Birmingham School of Medicine - Infectious Disease, Birmingham

50937

Universitatsklinikum Koeln Klinik I fur Innere Medizin Klinisches Studienzentrum fur Infektiologie I, Cologne

53127

Universitatsklinikum Bonn, Medizinische Klinik I - Bereich Infektiologie/HIV der Medizinischen Klinik, Bonn

60590

Universitätsklinikum Frankfurt -Medizinische Klinik II - Infektiologie, Frankfurt

60612

University of Illinois at Chicago College of Medicine - Division of Infectious Diseases, Chicago

68105

University of Nebraska Medical Center - Infectious Diseases, Omaha

70119

Southeast Louisiana Veterans Health Care System - Section of Infectious Diseases, New Orleans

78234

Brooke Army Medical Center, Fort Sam Houston

80204

Denver Health Division of Hospital Medicine - Main Campus, Denver

90095

University of California Los Angeles Medical Center - Westwood Clinic, Los Angeles

92314

Naval Medical Center San Diego - Infectious Disease Clinic, San Diego

98034

EvergreenHealth Infectious Disease Service, Kirkland

98104

The University of Washington - Virology Research Clinic, Seattle

98431

Madigan Army Medical Center - Infectious Disease Clinic, Tacoma

99204

Providence Sacred Heart Medical Center, Spokane

308442

National Centre for Infectious Diseases, Singapore

92868-3298

University of California Irvine Medical Center - Infectious Disease, Orange

94304-1207

VA Palo Alto Health Care System - Infectious Diseases, Palo Alto

95817-1460

University of California Davis Medical Center - Internal Medicine - Infectious Disease, Sacramento

94110-2859

University of California San Francisco - Zuckerberg San Francisco General Hospital - Division of Human Immunodeficiency Virus, Infectious Disease, and Global Medicine, San Francisco

94305-2200

Stanford University - Stanford Hospital and Clinics - Pediatrics - Infectious Diseases, Stanford

90048-1804

Cedars Sinai Medical Center, West Hollywood

30030-1705

Emory Vaccine Center - The Hope Clinic, Decatur

60611-2908

Northwestern Hospital - Infectious Disease, Chicago

21201-1509

University of Maryland School of Medicine - Center for Vaccine Development - Baltimore, Baltimore

21287-0005

Johns Hopkins Hospital - Medicine - Infectious Diseases, Baltimore

20892-1504

National Institutes of Health - Clinical Center, National Institute of Allergy and Infectious Diseases Laboratory Of Immunoregulation, Clinical Research Section, Bethesda

02114-2621

Massachusetts General Hospital - Infectious Diseases, Boston

01655-0002

University of Massachusetts Medical School - Infectious Diseases and Immunology, Worcester

55455-0341

University of Minnesota Medical Center, Fairview - Infectious Diseases and International Medicine, Minneapolis

63104-1015

Saint Louis University - Center for Vaccine Development, St Louis

10016-6402

New York University School of Medicine - Langone Medical Center - Microbiology - Parasitology, New York

14642-0001

University of Rochester Medical Center - Vaccine Research Unit, Rochester

10467-2401

Montefiore Medical Center - Infectious Diseases, The Bronx

19104-4238

Hospital of the University of Pennsylvania - Infectious Diseases, Philadelphia

37232-0011

Vanderbilt University Medical Center - Infectious Diseases, Nashville

77555-0435

University of Texas Medical Branch - Division of Infectious Disease, Galveston

77030-3411

Baylor College of Medicine - Molecular Virology and Microbiology, Houston

78229-3901

University of Texas Health Science Center at San Antonio - Infectious Diseases, San Antonio

22908-0816

University of Virginia - Acute Care Surgery, Charlottesville

P.O. 54636

AHEPA University Hospital - 1st Department of Internal Medicine, Thessaloniki

GR-10675

Medical School of Athens University - Evangelismos Hospital - Department of Critical Care and Pulmonary Services, Athens

162-8655

National Center for Global Health and Medicine Hospital - Disease Control and Prevention Center, Tokyo

03080

Seoul National University Hospital, Seoul

08036

Hospital Clinic Barcelona, Servicio de Salud Internacional, Barcelona

08916

Hospital Germans Trias i Pujol - Servei Malalties Infeccioses, Barcelona

BN2 5BE

Royal Sussex County Hospital - Department of Intensive Care Medicine, East Sussex

SE1 7EH

Saint Thomas' Hospital - Directorate of Infection, London

NE1 4LP

Royal Victoria Infirmary - Department of Infectious Diseases, Level 6, Ward 19

LS9 7TK

St. James's University Hospital - Infectious Diseases, Leeds

OX3 9DU

John Radcliffe Hospital, Headington, Oxford

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT04280705 - Adaptive COVID-19 Treatment Trial (ACTT) | Biotech Hunter | Biotech Hunter