A Study of Pevonedistat and Venetoclax Combined With Azacitidine to Treat Acute Myeloid Leukemia (AML) in Adults Unable to Receive Intensive Chemotherapy

PHASE2CompletedINTERVENTIONAL
Enrollment

164

Participants

Timeline

Start Date

October 13, 2020

Primary Completion Date

September 6, 2022

Study Completion Date

October 6, 2025

Conditions
Acute Myeloid Leukemia (AML)
Interventions
DRUG

Pevonedistat

Pevonedistat IV infusion.

DRUG

Venetoclax

Venetoclax tablets.

DRUG

Azacitidine

Azacitidine IV or SC injection.

Trial Locations (57)

10043

Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano

10126

Azienda Ospedaliera Citta della Salute e della Scienza di Torino, Turin

11042

Northwell Health Cancer Institute, Lake Success

11794

Stony Brook Medicine, Stony Brook

14033

Institut dHematologie de Basse Normandie, Caen

20089

Istituto Clinico Humanitas, Rozzano

20900

ASST di Monza - Azienda Ospedaliera San Gerardo, Monza

22908

University of Virginia Health System, Charlottesville

26506

West Virginia University Hospital, Morgantown

27100

Fondazione IRCCS Policlinico San Matteo di Pavia, Pavia

31059

EDOG - Institut Claudius Regaud - PPDS, Toulouse

32804

AdventHealth (Florida Hospital) - Transplant Institute, Orlando

33136

University of Miami Miller School of Medicine, Miami

38043

CHU de Grenoble, Grenoble

40138

Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi, Bologna

40207

Norton Cancer Institute - Suburban, Louisville

44093

CHRU Nantes, Nantes

44106

University Hospitals Cleveland Medical Center, Cleveland

50134

Azienda Ospedaliera Universitaria Careggi, Florence

53226

Medical College of Wisconsin, Milwaukee

57105

Avera Cancer Institute, Sioux Falls

59037

CHRU Lille, Lille

64132

HCA Midwest Health - SCRI - PPDS, Kansas City

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70112

Tulane Medical Center, New Orleans

72000

Centre Hospitalier Le Mans, Le Mans

73104

The University of Oklahoma Health Sciences Center, Oklahoma City

75012

Hopital Saint Antoine, Paris

75475

Hopital Saint Louis, Paris

77030

Houston Methodist Cancer Center, Houston

79410

Joe Arrington Cancer Research and Treatment Center, Lubbock

84143

Intermountain LDS Hospital, Salt Lake City

85234

Banner MD Anderson Cancer Center, Gilbert

86021

CHRU de Poitiers La Miletrie, Poitiers

89133

Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria

92093

UC San Diego Moores Cancer Center, La Jolla

92868

UC Irvine Medical Center, Orange

93009

Hopital Avicenne, Bobigny

02114

Massachusetts General Hospital, Boston

10029-6574

Icahn School of Medicine at Mount Sinai, New York

27514-4221

University of North Carolina at Chapel Hill, Chapel Hill

02903

Rhode Island Hospital, Providence

T6G 2G3

University of Alberta, Edmonton

T2N 4N2

Tom Baker Cancer Centre, Tom Baker Cancer Centre

N6A 5W9

London Health Sciences Centre, London

K1H 8L6

Ottawa Hospital, Ottawa

G1J 1Z4

Hopital de L'enfant Jesus, Québec

06202

CHU de Nice, Nice

06156

Ospedale Santa Maria Della Misericordia Di Perugia, Perugia

31-501

Szpital Uniwersytecki w Krakowie, Krakow

02-106

MTZ Clinical Research Sp z o o, Warsaw

02-776

Instytut Hematologii i Transfuzjologii, Warsaw

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok

85-168

Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy, Bydgoszcz

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

20-081

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, Lublin

93-513

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Takeda

INDUSTRY