40
Participants
Start Date
July 24, 2020
Primary Completion Date
November 5, 2021
Study Completion Date
February 9, 2022
Telaglenastat
Oral Glutaminase Inhibitor
Carboplatin Chemotherapy
IV infusion
Pemetrexed Chemotherapy
IV infusion
Pembrolizumab Immunotherapy
IV infusion
Placebo
Oral placebo
Folic acid 400 -1000 μg
Orally, once daily beginning 7 days prior to the first dose of pemetrexed and continue until 21 days after the last dose of pemetrexed.
Vitamin B12 1000 μg
Vitamin B12 1000 μg Intramuscular injection one week prior to the first dose of pemetrexed and once every 3 cycles (9 weeks) thereafter. Subsequent vitamin B12 injections may be given the same day as pemetrexed administration.
Dexamethasone 4 mg
For prophylaxis, orally twice per day (or equivalent). Taken the day before, day of, and day after pemetrexed administration.
New York University Langone (NYU), New York
Columbia University Medical Center, New York
Memorial Sloan Kettering Cancer Center, New York
Weill Cornell Medical College - New York Presbyterian Hospital, New York
Pelmutter Cancer Center at Winthrop, Mineola
New York Oncology Hematology, P.C., Clifton Park
New York Oncology Hematology, P.C. (400 Patoon Creek Blvd.), Albany
New York Oncology Hematology, P.C. (43 New Scotland Ave.), Albany
Roswell Park Comprehensive Cancer Center, Buffalo
UPMC Hillman Cancer Center, Pittsburgh
Pennsylvania State University Milton S. Hershey Medical Center, State College
Johns Hopkins Sibley Memorial Hospital, Washington D.C.
Sibley Memorial Hospital, Washington D.C.
Center for Cancer and Blood Disorders, Bethesda
Maryland Oncology Hematology - USOR, Columbia
Johns Hopkins Bayview Memorial Hospital, Baltimore
Frederick Health - James M. Stockman Cancer Institute, Frederick
Virginia Cancer Specialists, Fairfax
Virginia Commonwealth University (VCU) Massey Cancer Center, Richmond
Oncology and Hematology Associates of Southwest Virginia, Roanoke
Oncology and Hematology Associates of Southwest Virginia, Blacksburg
Oncology and Hematology Associates of Southwest Virginia, Salem
Oncology and Hematology Associates of Southwest Virginia, Wytheville
Oncology and Hematology Associates of Southwest Virginia, Low Moor
Cone Health at Alamance Regional, Burlington
Cone Health Cancer Center, Greensboro
Northwest Georgia Oncology, Marietta
Piedmont Cancer Institute, Atlanta
Emory University Hospital, Atlanta
University Cancer and Blood Center, Athens
Florida Cancer Specialist - Panhandle (SCRI), Tallahassee
Memorial Cancer Institute at Memorial Hospital West, Hollywood
University of Miami Sylvester Comprehensive Cancer Center, Miami
Holy Cross Hospital - Bines Cancer Center, Fort Lauderdale
Florida Cancer Specialist - East (SCRI), West Palm Beach
Boca Raton Regional Hospital Lynn Cancer Institute, Boca Raton
Moffitt Cancer Center, Tampa
Florida Cancer Specialist - North (SCRI), St. Petersburg
Florida Cancer Specialist - South (SCRI), Fort Myers
Ocala Oncology Center, Ocala
University of Alabama at Birmingham, Birmingham
University of South Alabama - Mitchell Cancer Center, Mobile
Tennessee Oncology - Nashville (SCRI), Nashville
Tennessee Oncology - Chattanooga (SCRI), Chattanooga
Ohio State University, James Cancer Hospital and Solove Research Institute, Columbus
Ohio Health, Columbus
Toledo Clinic Cancer Center, Toledo
Aultman Hospital, Canton
TriHealth Cancer Institute, Cincinnati
Beacon Health, South Bend
Fort Wayne Medical Oncology and Hematology, Fort Wayne
St. Joseph Mercy Hospital Cancer Care Center, Ypsilanti
Henry Ford Cancer Institute, Detroit
Bronson Methodist Hospital (West Michigan Cancer Center), Kalamazoo
Froedtert Hospital and the Medical College of Wisconsin (MCW), Milwaukee
University of Wisconsin Carbone Cancer Center, Madison
Minnesota Oncology Hematology, P.A., Saint Paul
Minnesota Oncology Hematology, P.A., Maplewood
Minnesota Oncology Hematology, P.A., Woodbury
Minnesota Oncology Hematology, P.A., Minneapolis
Minnesota Oncology Hematology, P.A., Coon Rapids
Minnesota Oncology Hematology, P.A., Edina
Sanford Health, Sioux Falls
Oncology of Northshore, Rolling Meadows
Orchard Healthcare Research Inc., Skokie
Washington University, St Louis
Central Care Cancer Center, Bolivar
University of Kansas Medical Center (KUMC), Westwood
Nebraska Methodist Hospital, Omaha
Pontchartrain Cancer Center, Covington
Oklahoma Cancer Specialists and Research Institute (OCSRI), Tulsa
Texas Oncology - Denison, Denison
Texas Oncology - Fort Worth Cancer Center, Fort Worth
Texas Oncology Beaumont - USOR, Beaumont
Oncology and Hematology of South Texas, Laredo
Texas Oncology - Austin Midtown, Austin
Texas Oncology - Austin Central, Austin
Texas Oncology - South Austin, Austin
Utah Cancer Specialist, Salt Lake City
University of Utah - Huntsman Cancer Institute, Salt Lake City
Yuma Regional Medical Center, Yuma
University of New Mexico Comprehensive Cancer Center, Albuquerque
Comprehensive Cancer Centers of Nevada, Las Vegas
University of Southern California (USC), Los Angeles
Cedars-Sinai Medical Center, Los Angeles
UCLA, Los Angeles
Loma Linda University Medical Center, Loma Linda
Compassionate Cancer Care, Fountain Valley
Providence Portland Medical Center, Portland
St. Joseph Heritage Healthcare, Fullerton
University of California Irvine, Chao Family Comprehensive Cancer Center, Orange
St. Joseph Heritage Healthcare - Santa Rosa, Santa Rosa
Hawaii Cancer Care, Honolulu
Oregon Health & Science University (OHSU) Knight Cancer Institute, Portland
University of Washington Seattle Cancer Care Alliance (SCCA), Seattle
Northwest Medical Specialities, Tacoma
Oncology Consultants, Houston
Massachusetts General Hospital, Boston
Dartmouth-Hitchcock Medical Center, Lebanon
New Jersey Cancer Care and Blood Disorders (NJCCBD), Belleville
Summit Medical Group, Berkeley Heights
The Valley Hospital - Luckow Pavilion, Paramus
Lead Sponsor
Calithera Biosciences, Inc
INDUSTRY