NCT04262843View on ClinicalTrials.gov

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

February 7, 2020

Primary Completion Date

January 4, 2026

Study Completion Date

January 4, 2026

Conditions
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaHigh Risk Myelodysplastic SyndromeMyelodysplastic Syndrome
Interventions
DRUG

Cyclophosphamide

Given IV

DRUG

Fludarabine

Given IV

DRUG

Fludarabine Phosphate

Given IV

BIOLOGICAL

Granulocyte Colony-Stimulating Factor

Growth factor therapy

PROCEDURE

Hematopoietic Cell Transplantation

Undergo hematopoietic cell transplantation

PROCEDURE

Intensity-Modulated Radiation Therapy

Undergo TMLI

DRUG

Mycophenolate Mofetil

Immunosuppressive therapy

DRUG

Tacrolimus

Immunosuppressive therapy

Trial Locations (1)

91010

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER