Neo-adjuvant Pembrolizumab in dMMR/ POLE-EDM Uterine Cancer Patients: a Feasibility Study

PHASE1CompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

November 1, 2020

Primary Completion Date

April 17, 2023

Study Completion Date

November 1, 2023

Conditions
Uterine Cancer
Interventions
DRUG

Pembrolizumab (Keytruda)

Pembrolizumab (Keytruda), 200mg IV Q3W for a total of 2 administrations per patient, integrated into standard-of-care protocol prior to surgery. Based on the well-established time lines, the interval between diagnosis and standard of care hysterectomy is sufficient to treat patients with two cycles of pembrolizumab without interfering with standard of care.

Trial Locations (1)

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

University Medical Center Groningen

OTHER

NCT04262089 - Neo-adjuvant Pembrolizumab in dMMR/ POLE-EDM Uterine Cancer Patients: a Feasibility Study | Biotech Hunter | Biotech Hunter