Regional Anesthesia in Total Hip and Knee Arthroplasty

PHASE4UnknownINTERVENTIONAL
Enrollment

135

Participants

Timeline

Start Date

September 30, 2022

Primary Completion Date

February 28, 2023

Study Completion Date

February 28, 2023

Conditions
Knee OsteoarthritisHip Osteoarthritis
Interventions
DRUG

Bupivacaine

Bupivacaine is a long-lasting dense sensory-motor block that can last up to four hours. It will be administered once, as part of the spinal anesthetic. The dosage varies based on age and joint, from 6.75 mg to 8.25 mg for the knee, and 7.5 mg to 9 mg for the hip.

DRUG

Ropivacaine

Ropivacaine is a long-acting local anesthetic that is known for its differential sensory-motor block. It will be administered once, as part of the spinal anesthetic. The dosage varies based on age and joint, from 9 mg to 11 mg for the knee, and 10 mg to 12 mg for the hip.

DRUG

Mepivacaine

Mepivacaine is an intermediate-acting local anesthetic producing shorting and motor-sparing blocks. It will be administered once, as part of the spinal anesthetic. The dosage varies based on age and joint, from 40 mg to 50 mg for the knee, and 45 mg to 55 mg for the hip.

All Listed Sponsors
lead

Ottawa Hospital Research Institute

OTHER