19
Participants
Start Date
May 1, 2019
Primary Completion Date
November 30, 2020
Study Completion Date
February 13, 2021
Supra-threshold and progressive doses of diluted capsaicin via a Koko Digidoser nebulizer
Participants will be exposured to increasing doses of aerosolized capsaicin (a known cough stimulant) through the Koko Digidoser nebulizer, while implementing behavioral cough suppression strategies. The concentration of capsaicin will increase incrementally as tolerated, as long as participants are still able to suppress cough. The concentration will never exceed 1000 micromolar. Participants will attend 6 treatment sessions and be given up to 12 exposures per treatment session. Participants will be encouraged to use cough suppression strategies outside of treatment sessions as much as possible to attempt to suppress cough.
Sub-threshold doses of diluted capsiacin via a KoKo Digidoser nebulizer
Participants will be repeatedly exposed to a sub-threshold dose of aerosolized capsaicin through the KoKo Digidoser nebulizer during treatment sessions. Participants will attend 6 treatment sessions and be given up to 12 exposures per treatment session. Participants will be encouraged to use cough suppression strategies outside of treatment sessions as much as possible to attempt to suppress cough.
University of Montana, Missoula
University of Montana
OTHER