A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

490

Participants

Timeline

Start Date

February 4, 2020

Primary Completion Date

September 6, 2022

Study Completion Date

July 31, 2025

Conditions
Small Cell Lung Cancer
Interventions
DRUG

Tiragolumab

Tiragolumab 600 milligrams (mg) administered by IV infusion on Day 1 of each 21-day cycle.

DRUG

Atezolizumab

Atezolizumab 1200 mg administered by IV infusion on Day 1 of each 21-day cycle.

DRUG

Carboplatin

Carboplatin was administered by IV infusion on Day 1 of each 21-day cycle for 4 cycles.

DRUG

Etoposide

Etoposide 100 mg/m\^2 administered by IV infusion on Days 1, 2 and 3 of each 21-day cycle for 4 cycles.

DRUG

Placebo

Placebo administered by IV infusion on Day 1 of each 21-day cycle.

Trial Locations (121)

333

Chang-Gung Medical Foundation, Linkou Branch, Taoyuan District

1011

CHUV, Lausanne

1023

Auckland City Hospital, Auckland

1121

Orszagos Koranyi TBC es Pulmonologiai Intezet, Budapest

1140

Klinik Penzing, Vienna

1210

Krankenhaus Nord - Klinik Floridsdorf, Vienna

2045

Tudogyogyintezet Torokbalint, Törökbálint

2050

Chris O'Brien Lifehouse, Camperdown

2747

Nepean Hospital, Kingswood

2800

AZ St Maarten Campus Leopoldstr, Mechelen

4575

Sunshine Coast University Hospital, Birtinya

5000

Clinique Ste-Elisabeth, Namur

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rend.Int., Szolnok

5112

Lyell McEwin Hospital, Elizabeth Vale

6020

Tiroler Landeskrankenanstalten Ges.M.B.H., Innsbruck

8091

UniversitätsSpital Zürich, Zurich

8800

AZ Delta (Campus Rumbeke), Roeselare

9100

Vitaz, Sint-Niklaas

10043

Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano

10048

National Taiwan University Hospital, Zhongzheng Dist.

10065

Memorial Sloan Kettering Cancer Center, New York

10408

National Cancer Center, Gyeonggi-do

11000

Clinical Center of Serbia, Belgrade

11080

Clinical Hospital Center ''Bezanijska Kosa'', Belgrade

11217

Taipei Veterans General Hospital, Taipei

13620

Seoul National University Bundang Hospital, Gyeonggi-do

13905

Broome Oncology - Binghamton, Binghamton

14165

Helios Klinikum Emil von Behring GmbH, Berlin

20007

MedStar Georgetown University Hospital (Lombardi Comprehensive Cancer Center), Washington D.C.

20089

IRCCS Istituto Clinico Humanitas, Rozzano

21075

Asklepios Klinik Harburg, Hamburg

21204

Institute for Pulmonary Diseases of Vojvodina, Kamenitz

21237

Weinberg Cancer Institution at Franklin Square, Baltimore

22031

Virginia Cancer Specialists, Fairfax

22927

LungenClinic Großhansdorf GmbH, Großhansdorf

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

24014

Blue Ridge Cancer Care, Roanoke

28040

Fundacion Jimenez Diaz, Madrid

28046

Hospital Universitario La Paz, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

29010

Hospital Clinico Universitario Virgen de la Victoria, Málaga

30060

Northwest Georgia Oncology Centers PC - Marietta, Marietta

33901

Florida Cancer Specialists, Fort Myers

34098

Istanbul University Cerrahpa?a-Cerrahpa?a Medical Faculty, Istanbul

34214

Medipol University Medical Faculty, Istanbul

34232

SCRI Florida Cancer Specialists North, Sarasota

34376

Fachklinik für Lungenerkrankungen, Immenhausen

35128

IRCCS Istituto Oncologico Veneto (IOV), Padua

35575

?zmir Medical Park, Izm?r

37203

Sarah Cannon Research Inst., Nashville

37404

Sarah Cannon Research Institute / Tennessee Oncology, Chattanooga

41013

Hospital Universitario Virgen del Rocio, Seville

44033

Ulsan University Hosiptal, Ulsan

46010

Hospital Clínico Universitario de Valencia, Valencia

48121

AUSL della Romagna, Ravenna

50009

Hospital Clinico Universitario Lozano Blesa, Zaragoza

51353

Samsung Changwon Hospital, Gyeongsangnam-do

53792

University of Wisconsin School of Medicine and Public Health, Madison

55404

Minnesota Oncology Hematology, Minneapolis

61615

Illinois Cancer Care, Peoria

70124

Irccs Ist. Tumori Giovanni Paolo Ii, Bari

70401

National Cheng-Kung University Hospital, Tainan City

78731

Texas Oncology Cancer Center, Austin

80124

Rocky Mountain Cancer Centers - Lone Tree, Lone Tree

80131

AORN Ospedali dei Colli Ospedale Monaldi, Napoli

82131

Asklepios Klinik Gauting, München-Gauting

89052

Comprehensive Cancer Centers of Nevada, Henderson

95123

Azienda Ospedaliero-Universitaria ?PoliclinicoVittorio Emanuele?- P.O. G. Rodolico, Catania

105229

Principal Military Clinical Hospital n.a. N.N. Burdenko, Moscow

119228

National University Hospital, Singapore

168583

National Cancer Centre, Singapore

187758

Scientific Research Institute n.a. N.N. Petrov, Saint Petersburg

04074

New England Cancer Specialists, Scarborough

60130-241

Oncocentro Serviços Médicos e Hospitalares Ltda, Fortaleza

41253-190

Hospital Sao Rafael - HSR, Salvador

99010-260

Hospital de Clínicas de Passo Fundo, Passo Fundo

91350-200

Hospital Nossa Senhora da Conceicao, Porto Alegre

89010-340

Clínica de Oncologia Reichow, Blumenau

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

775 20

Fakultni nemocnice Olomouc, Olomouc

703 84

Vitkovicka Nemocnice Bma, A.S., Ostrava

140 59

Thomayerova nemocnice, Praha 4 - Krc

570 10

"General Hospital G.Papanikolaou", Asvestochóri

115 27

Uoa Sotiria Hospital, Athens

155 62

Metropolitan General Hospital, Cholargós

711 10

Univ General Hosp Heraklion, Heraklion

277-8577

National Cancer Center Hospital East, Chiba

812-8582

Kyushu University Hospital, Fukuoka

951-8566

Niigata Cancer Center Hospital, Niigata

541-8567

Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Osaka

591-8555

NHO Kinki-Chuo Chest Medical Center, Osaka

362-0806

Saitama Cancer Center, Saitama

411-8777

Shizuoka Cancer Center, Shizuoka

104-0045

National Cancer Center Hospital, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

641-8510

Wakayama Medical University Hospital, Wakayama

6229 HX

Maastricht University Medical Center, Maastricht

3015 GD

Erasmus MC, Rotterdam

36-200

Szpital Specjalistyczny Podkarpacki O?rodek Onkologiczny, Brzozów

80-214

Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gdansk

31-202

Krakowski Szpital Specjalistyczny im sw.Jana Pawla II, Krakow

10-357

Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn

05-400

Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy, Otwock

60-569

Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan

02-781

Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad, Warsaw

Unknown

Blokhin Cancer Research Center, Moscow

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

Seoul St Mary's Hospital, Seoul

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

08036

Hospital Clinic Barcelona, Barcelona

01120

Adana Baskent University Hospital, Adana

06100

Ankara University Medical Faculty, Ankara

06500

Gazi University Medical Faculty, Ankara

EH4 2XU

NHS Lothian - Western General Hospital, Edinburgh

SE1 9RT

Guys and St Thomas Hospital, London

M20 4BX

Christie Foundation Trust, Manchester

TR1 3LQ

Royal Cornwall Hospital, Truro

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT04256421 - A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter