Effect of Paracetamol on Kidney Function in Severe Malaria

PHASE3RecruitingINTERVENTIONAL
Enrollment

460

Participants

Timeline

Start Date

December 13, 2021

Primary Completion Date

June 1, 2024

Study Completion Date

November 1, 2025

Conditions
Severe MalariaMalaria,FalciparumAcute Kidney InjuryParacetamol
Interventions
DRUG

Paracetamol

Paracetamol 15 mg/kg/dose IV 6 hourly for 72 hours

PROCEDURE

Mechanical antipyresis

"Mechanical antipyresis (i.e. loose clothing, tepid sponging, fanning and cooling blanket) if fever in the first 72 hours.~If a temperature \>38.5°C persists despite mechanical antipyresis, or if deemed necessary by the treating clinician, then paracetamol can be administered according to local practice (paracetamol IV 15 mg/kg as needed)."

Trial Locations (1)

Unknown

RECRUITING

The Kinshasa Medical Oxford Research Unit (KIMORU), Kinshasa

Sponsors
All Listed Sponsors
collaborator

Mahidol Oxford Tropical Medicine Research Unit

OTHER

collaborator

Kinshasa Medical Oxford Research Unit

UNKNOWN

lead

University of British Columbia

OTHER