Insulin Resistance in Multiple System Atrophy

NARecruitingINTERVENTIONAL
Enrollment

124

Participants

Timeline

Start Date

October 28, 2020

Primary Completion Date

October 28, 2026

Study Completion Date

October 28, 2027

Conditions
Multiple System Atrophy
Interventions
BIOLOGICAL

Homeostasis Model Assessment of insulin resistance (HOMA)

Fasting blood sample for : glucose, insulinemia, hemoglobin and lipid test to determine the Homeostasis Model Assessment of insulin resistance (HOMA) index

BEHAVIORAL

MOntreal Cognitive Assessment (MoCA)

Cognitive evaluation with MOntreal Cognitive Assessment (MoCA)

BEHAVIORAL

Clinical characteristics of AMS patients

Severity and progression of motor disorders assessed by the UMSARS scale, severity of dysautonomia assessed by the COMPASS31 scale ; quality of life questionnaire (AMS-Qol) for the level of difficulty experienced by the patient (on activities such as : move; walk; maintain balance; talk; feed)

PROCEDURE

Brain Magnetic Resonance Imaging (MRI)

Brain Magnetic Resonance Imaging (MRI) : putamen imaging, bridge and cerebellum; white substance hypersignals volume

BIOLOGICAL

Blood sampling

Optional blood sampling for the constitution of a biological collection

Trial Locations (1)

33 076

RECRUITING

CHU de Bordeaux, Bordeaux

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Bordeaux

OTHER

collaborator

Labex Brain

OTHER

collaborator

Centre National de la Recherche Scientifique, France

OTHER

lead

University Hospital, Bordeaux

OTHER