An Efficacy and Safety Study of Ravulizumab in ALS Participants

PHASE3TerminatedINTERVENTIONAL
Enrollment

382

Participants

Timeline

Start Date

March 30, 2020

Primary Completion Date

October 17, 2021

Study Completion Date

October 17, 2021

Conditions
Amyotrophic Lateral SclerosisALS
Interventions
DRUG

Placebo

Single loading dose via intravenous infusion, followed by regular maintenance dosing, based on weight.

BIOLOGICAL

Ravulizumab

Single loading dose via intravenous infusion, followed by regular maintenance dosing, based on weight.

Trial Locations (95)

2050

Brain and Mind Centre, Camperdown

2145

Westmead Hospital, Westmead

2400

Bispebjerg Hospital, Copenhagen

3000

UZ Leuven, Leuven

4029

Royal Brisbane and Women's Hospital, Herston

6009

Perron Institute for Neurological and Translational Science, Nedlands

8200

Aarhus University Hospital Department of Neurology, Aarhus

9007

Kantonsspital St. Gallen, Sankt Gallen

9100

Ålborg Universitets Hospital, Aalborg

10003

Beth Israel Medical Center - PRIME, New York

10021

Hospital for Special Surgery, New York

10126

University of Turin, Torino

13385

Hôpital de la Timone, Marseille

15212

Allegheny Neurological Associates, Pittsburgh

20132

Ospedale San Raffaele, Milan

20138

ICS Maugeri IRCCS, Milan

20149

Istituto Auxologico Italiano, Milan

21205

Johns Hopkins University School Of Medicine, Baltimore

23298

Virginia Commonwealth University, Neurology Clinical and Translational Research Office, Richmond

23456

Sentara Neurology Specialists, Virginia Beach

28016

Hospital San Rafael, Madrid

28207

Atrium Health Neuroscience Institute, Charlotte

30625

Medizinische Hochschule Hannover, Hanover

32209

University of Florida at Shands Jacksonville, Jacksonville

33612

University of South Florida, Tampa

34295

Hopital Gui de Chauliac, Montpellier

37044

CHU Tours - Hôpital Bretonneau, Tours

37099

Universitaetsmedizin Goettingen, Goettigen

37232

Vanderbilt University Medical Center, Nashville

40536

University of Kentucky, Lexington

43221

The Ohio State University, Columbus

44195

The Cleveland Clinic Foundation, Cleveland

46026

Hospital Universitari i Politecnic La Fe, Valencia

46202

Indiana University Medical Center, Indianapolis

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

59037

Hopital Roger Salengro - CHU Lille, Lille

60637

University of Chicago Medical Center, Chicago

66160

University of Kansas Medical Center Research Institute, Inc., Kansas City

69677

Hopital Neurologique Pierre Wertheimer, Bron

75651

Groupe Hospitalier Pitie-Salpetriere, Paris

77030

Houston Methodist Neurological Institute-Movement Disorders Clinic, Houston

Nerve & Muscle Center of Texas, Houston

78756

Austin Neuromuscular Center, Austin

80045

University of Colorado Anschutz Medical Campus School of Medicine, Aurora

81675

Klinikum rechts der Isar der TU Muenchen, Munich

85013

Barrow Neurological Institute, Phoenix

85028

Neuromuscular Research Center and Clinic, Phoenix

85251

HonorHealth Research Institute, Scottsdale

87042

CHU de Limoges - Hôpital Dupuytren, Limoges

89081

Universitaetsklinikum Ulm, Ulm

89145

Las Vegas Clinic, Las Vegas

90033

University of Southern California, Los Angeles

90127

Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone, Palermo

90185

Norrlands universitetssjukhus, Umeå

91096

Rambam Health Care Center, Haifa

91120

Hadassah University Hospital - Ein Kerem, Jerusalem

92354

Loma Linda University Medical Center, Loma Linda

92868

University of California-Irvine, Orange

94115

Norris MDA/ALS Center, San Francisco

94143

University of California San Francisco Medical Center, San Francisco

94304

Stanford University Medical Center, Palo Alto

6423906

Tel Aviv Sourasky Medical Center, Tel Aviv

92093-0949

University of California San Diego Medical Center, San Diego

02114

Massachusetts General Hospital, Boston

05401

University of Vermont Medical Center, Burlington

98122-4470

Swedish Neuroscience Institute, Seattle

T6G2S2

Heritage Medical Research Centre (HMRC), Edmonton

E3B 0C7

Stan Cassidy Center for Rehabilitation, Fredericton

N6A 5A5

LHSC - University Hospital, London

M4N 3M5

Toronto Sunnybrook Hospital, Toronto

H3A 2B4

Montreal Neurological Institute and Hospital, Montreal

G1J 1Z4

University Hospital of Quebec-Universite Laval, Québec

S7K 0M7

Royal University Hospital, Saskatoon

06001

CHU de Nice Hôpital Pasteur 2, Nice

07749

Universitaetsklinikum Jena, Jena

DUBLIN 9

Beaumont Hospital, Dublin

1355 - 41126

Azienda Ospedaliero-Universitaria di Modena - Ospedale Civile di Baggiovara, Modena

466-8560

Nagoya University Hospital, Nagoya

260-8677

Chiba University Hospital, Chiba

272-0827

Yoshino Neurology Clinic, Ichikawa-shi

980-8574

Tohoku University Hospital, Sendai

951-8520

Niigata University Medical & Dental Hospital, Niigata

520-2192

Shiga University of Medical Science Hospital, Ōtsu

770-8503

Tokushima University Hospital, Tokushima

113-8519

Medical Hospital, Tokyo Medical and Dental University, Bunkyō City

143-8541

Toho University Omori Medical Center, Ōta-ku

160-8582

Keio University Hospital, Shinjuku-Ku

3508 GA

University Medical Centre Utrecht, Utrecht

02-473

CityClinic, Warsaw

08907

Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

141 86

Karolinska Trial Alliance (KTA), Huddinge

WC1N 3BG

The National Hospital for Neurology & Neurosurgery, London

S10 2JF

Royal Hallamshire Hospital, Sheffield

Sponsors
All Listed Sponsors
lead

Alexion Pharmaceuticals, Inc.

INDUSTRY