A Comparison of mXELIRI Regimen and FOLFIRI Combined Bevacizumab Regimen as First-line Chemotherapy Regimen for Metastatic Colorectal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

264

Participants

Timeline

Start Date

May 1, 2018

Primary Completion Date

April 1, 2021

Study Completion Date

January 31, 2022

Conditions
Metastatic Colorectal Cancer
Interventions
BIOLOGICAL

Bevacizumab

5 mg/kg intravenously administered on day 1 of a 2-week cycle.

DRUG

Capecitabine

2000mg/m2/day oral on day 1 to day 10 of a 2-week cycle.

DRUG

Irinotecan

180 mg/m2 intravenously administered on day 1 of a 2-week cycle.

DRUG

5-FU

400 mg/m2 intravenous bolus on day 1 and 2400 mg/m2 continuous infusion over 44 hours of a 2-week cycle.

DRUG

CF

300 mg/m2 intravenously administered on day 1 of a 2-week cycle.

DRUG

Irinotecan

150 mg/m2 intravenously administered on day 1 of a 2-week cycle.

Trial Locations (1)

100021

Cancer Hospital & Institute, Chinese Academy of Medical Sciences, Beijing

All Listed Sponsors
collaborator

Beijing Hospital

OTHER_GOV

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

Liaoning Cancer Hospital & Institute

OTHER

collaborator

Jiangsu Cancer Institute & Hospital

OTHER

lead

Chinese Academy of Medical Sciences

OTHER

NCT04247984 - A Comparison of mXELIRI Regimen and FOLFIRI Combined Bevacizumab Regimen as First-line Chemotherapy Regimen for Metastatic Colorectal Cancer | Biotech Hunter | Biotech Hunter