Short RT Versus RCT,Followed by Chemo.and Organ Preservation for Interm and High-risk Rectal Cancer Patients

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

702

Participants

Timeline

Start Date

November 5, 2020

Primary Completion Date

September 15, 2023

Study Completion Date

September 15, 2028

Conditions
Rectal Cancer Stage III
Interventions
DRUG

Oxaliplatin, 85 mg/m2

85 mg/m2,2h-civ, day 22, 36, 50, 64, 78, 92, 106, 120, and 134 of therapy

DRUG

5FU; 2400 mg/m2

2400 mg/m2, 46h-civ, day 22, 36, 50, 64, 78, 92, 106, 120, 134 of therapy for Control arm

DRUG

5FU, 250 mg/m2

250 mg/m2 per day, civ, on day 1-14, day 22-35 of radiotherapy;

DRUG

5FU, 2400 mg/m2

2400 mg/m2,46h-civ, d64, d78, d92, d106, d120, d134 of therapy

DRUG

Oxaliplatin 50 mg/m2

50 mg/m2, 2h-civ, d1, d8, d21, d29 of radiotherapy and

DRUG

Folinic Acid, 400 mg/m2

2h-civ day 22, 36, 50, 64, 78, 92, 106, 120, and 134 of therapyfor Control arm; 400 mg/m2, 2h-civ d 64, d78, d92, d106, d120, d134 of therapy for experimental arm

RADIATION

Radiotherapy control, 5x5 Gy: 25 Gy

Control arm: 5x5 Gy (total: 25 Gy) 5 fractions

DRUG

Capecitabine, 1000 mg/m2

1000 mg/m2 (twice daily) day1-14 every three weeks instead of 5FU optional

DRUG

Oxaliplatin 85 mg/m2

85 mg/m2, 2h-civ, d64, d78, d92, d106, d120, d134 of therapy

RADIATION

radiotherapy experimental, 30 x 1,8 Gy: 54 Gy

30 x 1.8 Gy (total: 54 Gy), 5 fractions per week

DRUG

Capecitabine, 825 mg/m2

825 mg/m2 bid, per os, on day 1-14, 22-35 of RT instead of 5FU optional

DRUG

Oxaliplatin, 130 mg/m2

day1every three weeks (optional)

Trial Locations (76)

10249

Vivantes Clincial Center in Friedrichshain, Berlin

13125

Clincal Center Helios Berlin Buch, Berlin

13589

Ev. Waldkrankenhaus, Spandau,, Berlin

14650

Helios Klinikum Berlin Emil von Behring, Berlin

15526

Clincal Center Helios Bad Saarrow, Bad Saarow

17036

Dietrich Bonhoeffer Klinik, Neubrandenburg

18059

University Clinic Rostock, Rostock

23538

Uniklinik Schleswig Holstein, Lübeck

24105

University Clinic Kiel, Kiel

25121

Pius Hospital, Oldenburg, Oldenburg

26133

University Clinic Oldenburg, Oldenburg

26789

Oncology UnterEms, Leer, Leer

30171

Medical Project Hannover, Hanover

31134

"St. Bernward Clincal Center Hildesheim", Hildesheim

31135

Oncology in Medicinum Hildesheim, Hildesheim

31785

Hematological-Oncological Practice Dr. Oleg Rubanov, Hameln, Hamelin

32756

Clinic Lippe GmbH (Lemgo/Detmold), Detmold

33098

Brother clinic St. Josef, Paderborn, Paderborn

St. Vincenz Hospital Paderborn, Paderborn

33604

Klinikum Bielefeld, Bielefeld

33615

Franziskus Hospital Bielefeld, Bielefeld

34121

DRK Clincal Centers North Hessen Kassel, Kassel

35043

University Clinic Marburg, Marburg

35392

Praxis für Hämatologie und Onkologie, Giessen

35578

Lahn-Dill Clinics Wetzlar, Wetzlar

36043

Clinic Fulda, Fulda

37075

University Clinic Göttingen, Göttingen

38440

Clinic Wolfsburg, Wolfsburg

38642

MVZ Oncological Cooperation Harz, Goslar

39120

University Clinic Magdeburg, Magdeburg

41063

Clinic Maria Hilf GmbH, Mönchengladbach

44791

St. Josef Hospital of the catholic clinic Bochum, Bochum

44892

Hospital Bochum, Bochum

45122

University Clinic Essen, Essen

45136

"Clinical Center Essen Mitte", Essen

45659

Prosper Hospital Recklinghausen, Recklinghausen

46485

Evangelical Clinic Wesel, Wesel

47805

Alexianer Krefeld GmbH / Maria Hilf Krankenhaus, Krefeld

48431

Mathias-Spital, Rheine, Rheine

54290

"Clinical Center Mutterhaus Trier", Trier

55116

University Clinic Mainz, Mainz

60488

Clinic North West gGmbH Frankfurt, Frankfurt am Main

60590

Department of Radiooncology, Frankfurt

63069

Sana Clinical Center Offenbach, Offenbach

64283

Clincal Center Darmstadt, Darmstadt

64287

Onkologische Schwerpunktpraxis, Darmstadt

66113

CaritasClinic Saarbrücken, Saarbrücken

Med. Statistik Saarbrücken GgR, Saarbrücken

68167

University Clinic Mannheim, Mannheim

70174

Clinic Stuttgart, Stuttgart

72076

University Clinic for Radioncology Tübingen, Tübingen

73557

Clinic Ostlab, Staufenclinic Schwaeb.Gmuend, Mutlangen, Mutlangen

73730

Clincal Center Esslingen, Esslingen am Neckar

73760

Medius Clincal Center Ostfildern-Ruit, Ostfildern

77654

Pi.Tri-Studien GmbH, Offenburg, Offenburg

78052

Schwarzwald-Baar-Kliniken, Villingen-Schwenningen

79106

University Clinic Freiburg, Freiburg im Breisgau

81675

Technical University Clinic Munich, München

Technical University Munich, München

81925

"Clincal Center Bogenhausen Munich", München

87439

Klinikverbund Allgäu, Kempten (Allgäu)

89081

University Clinic Ulm, Ulm

91054

University Clinic Erlangen, Erlangen

92224

"Clincal Center St. Marien Amberg", Amberg

92637

Clinic Nordoberpfalz AG, Clinic Weiden, Weiden

93046

"Hospital Barmherzige Brüder Regensburg", Regensburg

93053

University Clinic Regensburg, Regensburg

95445

Clinic Bayreuth GmbH, Bayreuth

96450

Clinical Center Coburg, Coburg

97080

University Clinic Würzburg, Würzburg

09113

Clincal Center Chemnitz, Chemnitz

01067

Radiotherapy Practice Dr. A. Schreiber, Dresden, Dresden

01307

Oncology Practice Dresden, Dresden

04103

University Clinic Leipzig, Leipzig

04129

Clinic Sankt Georg gGmbH, Leipzig, Leipzig

06120

Universitätsklinikum Halle, Halle

All Listed Sponsors
lead

Prof. Dr. med. Claus Rödel

OTHER