NATriuretic Response to Expansion and dIUretics in huMans With Heart Failure

NACompletedINTERVENTIONAL
Enrollment

229

Participants

Timeline

Start Date

April 1, 2020

Primary Completion Date

April 26, 2021

Study Completion Date

April 26, 2021

Conditions
Heart Failure
Interventions
DRUG

Ringer's (8.6 g/L sodium chloride, 0.33 g/L calcium chloride, 0.3 g/L potassium chloride) Solution

A 2-hour of infusion of Ringer's (8.6 g/L sodium chloride, 0.33 g/L calcium chloride, 0.3 g/L potassium chloride) solution will be given following completion of the first 3-hour urine collection period: 0.5 liter infused over 10 min followed by 0.5 liter infused over 1 hour 50 minutes.

DRUG

Intravenous Bolus Furosemide

Following completion of the second 3-hour urine collection period and after the second set of blood and urine samples are obtained, 40 mg of furosemide will be given as an IV bolus.

Trial Locations (13)

Unknown

Erebouni Medical Center CJSC, Yerevan

Institute of Cardiology named after L.A. Hovhannisyan, Yerevan

Nairi Medical Center, Yerevan

Yerevan State Medical University, Yerevan

University Clinical Center Republic of Srpska, Banja Luka Department of Cardiology, Banja Luka

University Clinical Center Mostar, Mostar

"Regional budget Healthcare Institution Cardiological dispensary", Ivanovo

"Moscow State Budgetary Institution of Healthcare of Moscow City Clinical Hospital named after V.V. Vinogradov of the Department of Healthcare of Moscow", Moscow

"State Budgetary Healthcare Institution of Moscow City clinical hospital #51 of the Department of Healthcare of Moscow", Moscow

"State Budgetary Healthcare Institution of Moscow City Clinical Hospital named after V.V. Veresaev of the Department of Healthcare of Moscow", Moscow

"State Budgetary Healthcare Institution of Moscow Moscow City Clinical Hospital named after V.M. Buyanov of the Department of Healthcare of Moscow", Moscow

MedFort LLC, Saint Petersburg

"State Budgetary Healthcare Institution of Vladimir region Vladimir City Hospital # 4", Vladimir

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Saint-Louis-Lariboisière University Hospitals

UNKNOWN

collaborator

Abbott

INDUSTRY

lead

Momentum Research, Inc.

INDUSTRY